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Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10 (show PRLHR ELISA Kits), GPR54 (show KISS1R ELISA Kits) and GPR103 (show QRFPR ELISA Kits).
The NPFF2 neuropeptide FF receptor phosphorylation sites have been mapped and their role identified in receptor regulation.
These data show that NPFF (show NPFF ELISA Kits)-induced heterologous desensitization of MOP receptor (show OPRM1 ELISA Kits) signaling is mediated by GRK2 (show ADRBK1 ELISA Kits) and could involve transphosphorylation within the heteromeric receptor complex.
Four genetic loci were strongly and independently associated with obesity, NPY2R (show NPY2R ELISA Kits), NPFFR2, MC4R (show MC4R ELISA Kits), and FTO (show FTO ELISA Kits).
Besides regulation of reproduction, kisspeptins have a potential to mediate physiological effects on autonomic regulation and nociception in humans via the NPFF2R pathways.
species-related differences in the binding properties of NPFF(2) receptors
Evidence does not support the hypothesis that NPGPR is involved in feeding regulation.
The BIBP3226 and PFR(Tic)amide, on Human neuropeptide FF receptor subtype 2 (hNPFF2) were investigated.
neuropeptide FF analogs show that NPFF2 receptors couple to the four subunits assayed.
expression of hNPFF2 receptor mRNA was up-regulated by neuropeptide FF
Results indicate that NPFF signaling through NPFFR2 contributes to diabetic corneal nerve injury recovery and epithelial wound healing. Neuropeptide FF is a potential neuroregenerative factor for diabetic sensory nerve injury.
kisspeptin can act partly through neuropeptide FF receptors to modulate neuronal activity independent of GPR54 (show KISS1R ELISA Kits) in the mouse brain.
two central controllers of reproductive function, gonadotropin-releasing hormone (GnRH) and kisspeptin, stimulate the expression of Gonadotropin-inhibitory hormone (GnIH) receptors in pituitary gonadotroph cells and hypothalamic GnRH neurons
mRNA levels of NPFF2 receptor were up-regulated in macrophages when treated with Lipopolysaccharide for 24 to 72 h.
Data showed that 33% of GnRH (show GNRH1 ELISA Kits) neurons and 9-16% of rostral periventricular kisspeptin neurons expressed Gpr147 (show NPFFR1 ELISA Kits), whereas Gpr74 was not expressed in either population.
Mouse kisspeptin-8 and kisspeptin-13 produce very small currents in NPFF2 receptor-injected Xenopus oocytes, compared to human kisspeptin.
central NPFF1 (show NPFFR1 ELISA Kits) and NPFF2 receptors control in an opposite manner the body temperature in mice.
The distribution pattern of NPFF2 receptors in the diencephalon and the superficial layers of the spinal cord is consistent with a hypothesized potential role for NPFF in the modulation of sensory input and opioid analgesia.
NPFF (show NPFF ELISA Kits) system may also have species-specific features since the NPFF2 receptor mRNA expression differs from that reported for rat
This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants.
neuropeptide FF receptor 2
, G protein-coupled receptor 74
, G-protein coupled receptor 74
, G-protein coupled receptor HLWAR77
, neuropeptide FF 2
, neuropeptide G-protein coupled receptor
, neuropeptide NPFF receptor