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Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation.
Findings suggest a novel and gender-specific role for INSL3 (show INSL3 Proteins) and cognate receptor RXFP2 signaling in ocular surface homeostasis.
These results provide new mechanistic insights into the binding and activation events of RXFP1 (show RXFP1 Proteins) and RXFP2 by their native hormone ligands.
Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin
relaxin-2 (show RLN1 Proteins) and its receptors RXFP1 (show RXFP1 Proteins) and RXFP2 are expressed in GSV and their expression is significantly decreased in varicose GSV
haplotype analysis of the RXFP2 gene in T222P carriers and their parents showed that this variant is linked to the previously inferred C-C-G-A-13 haplotype and consequently provides further support to the 'founder effect' hypothesis
higher expression of LGR8 may facilitate tumor invasiveness in the early clinical stage of hepatocellular carcinoma.
Data show that synthetic parallel dimer of the B-chain of INSL3 (show INSL3 Proteins) is a potent inhibitor of the native peptide's binding to its receptor, RXFP2.
the only clinical consequence of alterations of the INSL3 (show INSL3 Proteins)-LGR8 system seems to be failure of the testis to normally descend in the scrotum during embryonic development, without affecting the spermatogenic and endocrine components of the testis itself
mutations involving the human LGR8 gene do not represent a frequent cause of cryptorchidism in the Finnish population
Results suggest that DES (show DES Proteins) causes testicular maldescent by altering the LGR8 pathway in mouse gubernaculum testis cells.
The results displayed that INSL3 (show INSL3 Proteins) changed RXFP2 expression in mouse gubernaculum testis cells in vitro
data suggest a novel role for Rln (show RLN1 Proteins) in craniofacial skeletal development and metabolism through Rxfp2
Rxfp1 (show RXFP1 Proteins), Rxfp2, and Nr3c1 (show NR3C1 Proteins) mRNAs were expressed on the developing maxilla and mandible, Meckel's cartilage, tongue, and tooth primordia between mouse embryonic days 13.5-18.5.
Spermatogonial stem cells undergo drastic depletion in the cryptorchid testes of RXFP2 deficient mice.
Data suggest that Insl3 (show INSL3 Proteins)/Rxfp2 (insulin-like peptide 3 (show INSL3 Proteins)/relaxin receptor 2) signaling is important for testicular descent; however, germ-cell deletion of Rxfp2 did not affect spermatogenesis, germ cell survival, or male fertility.
Prenatal exposure to diethylstilbestrol increased the expression of LGR8 mRNA in the mouse gubernaculum testis.
A deficiency for Rxfp2 on Cav1 (show CAV1 Proteins)-deficient background led to more than a 2-fold increase in the incidence of uterine cysts.
A mouse model was created containing a novel missense mutation in Relaxin/insulin-like family peptide receptor 2 which likely prevents binding to its ligand, Insulin-like peptide 3 (show INSL3 Proteins), resulting in failure of the transabdominal phase of testicular descent.
RXFP2 signaling pathway plays an important role in mediating androgen action to stimulate gubernaculum development during inguinoscrotal testis descent.
This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
G protein coupled receptor affecting testicular descent
, G-protein coupled receptor 106
, G-protein coupled receptor affecting testicular descent
, leucine-rich repeat-containing G protein-coupled receptor 8
, leucine-rich repeat-containing G-protein coupled receptor 8
, relaxin family peptide receptor 2
, relaxin receptor 2
, G protein-coupled receptor 106
, INSL3 receptor