Browse our RXFP2 Proteins (RXFP2)

On are 5 Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2) Proteins from 2 different suppliers available. Additionally we are shipping RXFP2 Antibodies (67) and RXFP2 Kits (3) and many more products for this protein. A total of 78 RXFP2 products are currently listed.
Gpcr, Gpr106, Great, INSL3R, Lgr8, LGR8.1, RXFPR2
list all proteins Gene Name GeneID UniProt
RXFP2 122042 Q8WXD0
RXFP2 140498 Q91ZZ5
Rat RXFP2 RXFP2 363866  

RXFP2 Proteins (RXFP2) by Origin

More Proteins for RXFP2 Interaction Partners

Human Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2) interaction partners

  1. In the TMD (show TTN Proteins) discovery cohort, sex-stratified analysis identified 2 additional genome-wide significant loci in females. One lying upstream of the relaxin/insulin-like family peptide receptor 2 ( RXP2) (chromosome 13, rs60249166,[OR] = 0.65, P = 3.6 x 10(-8)) was replicated among females in the meta-analysis (1-tailed P = 0.052). The other (chromosome 17, rs1531554, OR = 0.68, P = 2.9 x 10(-8)) was replicated among f

  2. Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation.

  3. Findings suggest a novel and gender-specific role for INSL3 (show INSL3 Proteins) and cognate receptor RXFP2 signaling in ocular surface homeostasis.

  4. These results provide new mechanistic insights into the binding and activation events of RXFP1 (show RXFP1 Proteins) and RXFP2 by their native hormone ligands.

  5. Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin

  6. relaxin-2 (show RLN1 Proteins) and its receptors RXFP1 (show RXFP1 Proteins) and RXFP2 are expressed in GSV and their expression is significantly decreased in varicose GSV

  7. haplotype analysis of the RXFP2 gene in T222P carriers and their parents showed that this variant is linked to the previously inferred C-C-G-A-13 haplotype and consequently provides further support to the 'founder effect' hypothesis

  8. higher expression of LGR8 may facilitate tumor invasiveness in the early clinical stage of hepatocellular carcinoma.

  9. Data show that synthetic parallel dimer of the B-chain of INSL3 (show INSL3 Proteins) is a potent inhibitor of the native peptide's binding to its receptor, RXFP2.

  10. the only clinical consequence of alterations of the INSL3 (show INSL3 Proteins)-LGR8 system seems to be failure of the testis to normally descend in the scrotum during embryonic development, without affecting the spermatogenic and endocrine components of the testis itself

Mouse (Murine) Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2) interaction partners

  1. Results suggest that DES (show DES Proteins) causes testicular maldescent by altering the LGR8 pathway in mouse gubernaculum testis cells.

  2. The results displayed that INSL3 (show INSL3 Proteins) changed RXFP2 expression in mouse gubernaculum testis cells in vitro

  3. data suggest a novel role for Rln (show RLN1 Proteins) in craniofacial skeletal development and metabolism through Rxfp2

  4. Rxfp1 (show RXFP1 Proteins), Rxfp2, and Nr3c1 (show NR3C1 Proteins) mRNAs were expressed on the developing maxilla and mandible, Meckel's cartilage, tongue, and tooth primordia between mouse embryonic days 13.5-18.5.

  5. Spermatogonial stem cells undergo drastic depletion in the cryptorchid testes of RXFP2 deficient mice.

  6. Data suggest that Insl3 (show INSL3 Proteins)/Rxfp2 (insulin-like peptide 3 (show INSL3 Proteins)/relaxin receptor 2) signaling is important for testicular descent; however, germ-cell deletion of Rxfp2 did not affect spermatogenesis, germ cell survival, or male fertility.

  7. Prenatal exposure to diethylstilbestrol increased the expression of LGR8 mRNA in the mouse gubernaculum testis.

  8. A deficiency for Rxfp2 on Cav1 (show CAV1 Proteins)-deficient background led to more than a 2-fold increase in the incidence of uterine cysts.

  9. A mouse model was created containing a novel missense mutation in Relaxin/insulin-like family peptide receptor 2 which likely prevents binding to its ligand, Insulin-like peptide 3 (show INSL3 Proteins), resulting in failure of the transabdominal phase of testicular descent.

  10. RXFP2 signaling pathway plays an important role in mediating androgen action to stimulate gubernaculum development during inguinoscrotal testis descent.

RXFP2 Protein Profile

Protein Summary

This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with RXFP2

  • relaxin/insulin-like family peptide receptor 2 (RXFP2)
  • relaxin/insulin-like family peptide receptor 2 (Rxfp2)
  • Gpcr protein
  • Gpr106 protein
  • Great protein
  • INSL3R protein
  • Lgr8 protein
  • LGR8.1 protein
  • RXFPR2 protein

Protein level used designations for RXFP2

G protein coupled receptor affecting testicular descent , G-protein coupled receptor 106 , G-protein coupled receptor affecting testicular descent , leucine-rich repeat-containing G protein-coupled receptor 8 , leucine-rich repeat-containing G-protein coupled receptor 8 , relaxin family peptide receptor 2 , relaxin receptor 2 , G protein-coupled receptor 106 , INSL3 receptor

122042 Homo sapiens
140498 Mus musculus
363866 Rattus norvegicus
450220 Canis lupus familiaris
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