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Browse our Metalloproteinase Inhibitor 2 Proteins (TIMP2)

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Metalloproteinase Inhibitor 2 Proteins (TIMP2)
On are 47 Metalloproteinase Inhibitor 2 (TIMP2) Proteins from 16 different suppliers available. Additionally we are shipping Metalloproteinase Inhibitor 2 Antibodies (316) and Metalloproteinase Inhibitor 2 Kits (96) and many more products for this protein. A total of 470 Metalloproteinase Inhibitor 2 products are currently listed.
CSC-21K, D11Bwg1104e, DDC8, etID32613.12, fa96h09, Timp-2, timp2, wu:fa96h09, zgc:136726
list all proteins Gene Name GeneID UniProt
TIMP2 7077 P16035
TIMP2 29543 P30121
TIMP2 21858  

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Metalloproteinase Inhibitor 2 Proteins (TIMP2) by Origin

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Top referenced Metalloproteinase Inhibitor 2 Proteins

  1. Human TIMP2 Protein expressed in HEK-293 - ABIN2666719 : Bourboulia, Stetler-Stevenson: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion. in Seminars in cancer biology 2010 (PubMed)
    Show all 5 references for ABIN2666719

  2. Human TIMP2 Protein expressed in Human Cells - ABIN2002769 : Seo, Li, Guedez, Wingfield, Diaz, Salloum, Wei, Stetler-Stevenson: TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism. in Cell 2003 (PubMed)
    Show all 3 references for ABIN2002769

  3. Human TIMP2 Protein expressed in HEK-293 Cells - ABIN2181824 : Stetler-Stevenson, Krutzsch, Liotta: Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family. in The Journal of biological chemistry 1989 (PubMed)
    Show all 3 references for ABIN2181824

  4. Human TIMP2 Protein expressed in Escherichia coli (E. coli) - ABIN1098377 : Bahudhanapati, Zhang, Sidhu, Brew: Phage display of tissue inhibitor of metalloproteinases-2 (TIMP-2): identification of selective inhibitors of collagenase-1 (metalloproteinase 1 (MMP-1)). in The Journal of biological chemistry 2011 (PubMed)
    Show all 2 references for ABIN1098377

  5. Human TIMP2 Protein expressed in Escherichia coli (E. coli) - ABIN1047368 : Stetler-Stevenson, Brown, Onisto, Levy, Liotta: Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. in The Journal of biological chemistry 1990 (PubMed)
    Show all 2 references for ABIN1047368

More Proteins for Metalloproteinase Inhibitor 2 Interaction Partners

Human Metalloproteinase Inhibitor 2 (TIMP2) interaction partners

  1. High TIMP2 expression is associated with chronic myelogenous leukemia.

  2. No significant association was observed in MMP13 (show MMP13 Proteins), TIMP2 and TGFB3 (show TGFB3 Proteins) genes with CP or PI. CP is a risk factor to develop PI, however, there is no association of both diseases with polymorphisms in the MMP13 (show MMP13 Proteins), TIMP2 and TGFB3 (show TGFB3 Proteins) genes

  3. MMP-2 (show MMP2 Proteins) and TIMP-2 were secreted by both tumor cells and stromal cells.

  4. miR (show MLXIP Proteins)-22 significantly upregulated the invasion capacity of 1321N1 cells. In silico analysis predicted that TIMP2 is a target gene of miR (show MLXIP Proteins)-22 which was confirmed by qPCR and Western blotting. Luciferase reporter assays demonstrated that miR (show MLXIP Proteins)-22 directly bound the 3'-untranslated regions of TIMP2. These data suggest that miR (show MLXIP Proteins)-22 acts to regulate invasion of 1321N1 astrocytoma cells by targeting TIMP2 expression.

  5. TIMP-1 (show TIMP1 Proteins) and-2 are primarily markers of an early function of the transplanted kidney.

  6. Results show decreased expression of MMP-2 (show MMP2 Proteins), MMP-9 (show MMP9 Proteins) and TIMP-2 genes on both mRNA and protein levels in depression; there elevated expression positively affects cognitive efficiency.

  7. TIMP- 2 expression decreased in cervical disc herniation patients.

  8. significant differences were detected concerning the activity of TIMPs resulting in a negative correlation of TIMP1 (show TIMP1 Proteins) activity with MMP2 (show MMP2 Proteins) activity (p = 0.044) and negative correlations of TIMP2 and TIMP3 (show TIMP3 Proteins) with MMP9 (show MMP9 Proteins) activity

  9. quantitative urine test is available to assess the risk of developing AKI by measuring the concentrations of two protein biomarkers, TIMP-2 and IGFBP-7 (show IGFBP7 Proteins)

  10. Here we report isothermal titration calorimetric studies of the effects of selectivity-modifying mutations in NTIMP1 and NTIMP2 on the thermodynamics of their interactions with MMP1 (show MMP1 Proteins), MMP3 (show MMP3 Proteins), and MMP14 (show MMP14 Proteins).

Cow (Bovine) Metalloproteinase Inhibitor 2 (TIMP2) interaction partners

  1. Data indicate the involvement of PKC-alpha (show PKCa Proteins) in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB (show NFKB1 Proteins)-MT1-MMP (show MMP14 Proteins)-dependent and -independent pathway.

  2. A differential pattern of matrix metalloproteinase-2 (show MMP2 Proteins) and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.

  3. MMP-14 (show MMP14 Proteins), MMP-2 (show MMP2 Proteins) and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.

  4. Results describe distinct changes in expression of MMP2 (show MMP2 Proteins), MMP14 (show MMP14 Proteins), and the metallopeptidase (show ECEL1 Proteins) inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine regulation.

  5. Production of TIMP-1 (show TIMP1 Proteins) was augmented by IL-1alpha, TNFalpha (show TNF Proteins), and hepatocyte growth factor (show HGF Proteins) at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments.

  6. the different temporal expression patterns of TIMP-1 (show TIMP1 Proteins) and TIMP-2 suggest that TIMP-1 (show TIMP1 Proteins) may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance

  7. Identification, purification and partial characterization of timp-2 in bovine pulmonary artery smooth muscle

  8. Results describe the isolation of matrix metalloproteinase 2 (MMP-2 (show MMP2 Proteins)) from the MMP-2 (show MMP2 Proteins)/tissue inhibitor of metalloproteinase 2 (TIMP-2) complex, and the characterization of both isolated MMP-2 (show MMP2 Proteins) and the complex itself.

  9. oxidants inactivate TIMP-2, and the resulting activation of MMP-2 (show MMP2 Proteins) subsequently inhibits Na+ dependent Ca2 (show CA2 Proteins)+ uptake in the microsomes

  10. TIMP-2 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.

Horse (Equine) Metalloproteinase Inhibitor 2 (TIMP2) interaction partners

  1. The pathology of laminitis is associated with increased and lowered transcription of MMP-14 (show MMP14 Proteins) and TIMP-2, respectively.

Mouse (Murine) Metalloproteinase Inhibitor 2 (TIMP2) interaction partners

  1. demonstrate that TIMP-2 plays a greater protective role than TIMP-1 (show TIMP1 Proteins) during the pathogenesis of atherosclerosis

  2. Further investigation of MMP2 (show MMP2 Proteins) inhibitors of TIMP2/TIMP4 (show TIMP4 Proteins) showed an upregulated TIMP2 expression, but not TIMP4 (show TIMP4 Proteins). low-dose pre-radiation attenuates the skin inflammation and ROS (show ROS1 Proteins) production induced by medium-dose UV radiation

  3. TIMP2 and TIMP3 (show TIMP3 Proteins) play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function

  4. Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK (show MAPK14 Proteins) signaling pathway.

  5. High TIMP2 expression is associated with liver fibrosis.

  6. TIMP2 promotes kidney injury through metalloproteinase (MMP)2 (show MMP2 Proteins) activation

  7. Gene expression of Mmp-12 (show MMP12 Proteins) and Mmp-13 (show MMP13 Proteins), and Timp-1 (show TIMP1 Proteins) was strongly upregulated at all time points in RD compared with controls. Timp-2, Mmp-2 (show MMP2 Proteins), and Mmp-9 (show MMP9 Proteins) expression was modest.

  8. Data indicate a significantly increased expression of type I collagen, TIMP-2, TGF-beta (show TGFB1 Proteins), PAI-1 (show SERPINE1 Proteins) and RAGE (show AGER Proteins) in diabetic db/db (show LEPR Proteins) cells.

  9. This study suggests that miR-17 participates in the regulation of cardiac matrix remodeling and provides a novel therapeutic approach using miR-17 inhibitors to prevent remodeling and heart failure after MI.

  10. In neural stem cells, TIMP-2 acts as key effector of the proneurogenic response to inducing stimuli such as Marimastat.

Zebrafish Metalloproteinase Inhibitor 2 (TIMP2) interaction partners

  1. To further study the function of TIMP-2 in development, we utilized zebrafish as an experimental model system

  2. membrane-type 1 metalloproteinase, gelatinase A (show MMP2 Proteins) , and tissue inhibitor 2 of metalloproteinases mRNA transcripts were expressed in the blastema

Metalloproteinase Inhibitor 2 (TIMP2) Protein Profile

Protein Summary

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Alternative names and synonyms associated with Metalloproteinase Inhibitor 2 (TIMP2)

  • TIMP metallopeptidase inhibitor 2 (TIMP2)
  • TIMP metallopeptidase inhibitor 2 (Timp2)
  • tissue inhibitor of metalloproteinase 2 (Timp2)
  • tissue inhibitor of metalloproteinase 2a (timp2a)
  • CSC-21K protein
  • D11Bwg1104e protein
  • DDC8 protein
  • etID32613.12 protein
  • fa96h09 protein
  • Timp-2 protein
  • timp2 protein
  • wu:fa96h09 protein
  • zgc:136726 protein

Protein level used designations for TIMP2

TIMP-2 , metalloproteinase inhibitor 2 , tissue inhibitor of metalloproteinase 2 , tissue inhibitor of metalloproteinases 2 , collagenase inhibitor , tissue inhibitor of mettaloproteinase 2 , tissue inhibitor of metalloproteinase-2 , tissue inhibitor of matrix metalloproteinase-2 , metalloproteinase inhibitor TIMP-2

7077 Homo sapiens
29543 Rattus norvegicus
282093 Bos taurus
100008689 Oryctolagus cuniculus
374178 Gallus gallus
396988 Sus scrofa
100034134 Equus caballus
403633 Canis lupus familiaris
743167 Pan troglodytes
100217406 Ovis aries
21858 Mus musculus
100135629 Cavia porcellus
359835 Danio rerio
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