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Human APOC3 ELISA Kit for Sandwich ELISA - ABIN2683478
Duivenvoorden, Teusink, Rensen, Romijn, Havekes, Voshol: Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice. in Diabetes 2005
Show all 5 Pubmed References
Human APOC3 ELISA Kit for Sandwich ELISA - ABIN612668
Cooke, Perlmutter: Expression of a novel form of the fyn proto-oncogene in hematopoietic cells. in The New biologist 1991
Show all 12 Pubmed References
Human APOC3 ELISA Kit for Sandwich ELISA - ABIN414856
Minicocci, Tikka, Poggiogalle, Metso, Montali, Ceci, Labbadia, Fontana, Di Costanzo, Maranghi, Rosano, Ehnholm, Donini, Jauhiainen, Arca: Effects of angiopoietin-like protein 3 deficiency on postprandial lipid and lipoprotein metabolism. in Journal of lipid research 2016
Rat (Rattus) APOC3 ELISA Kit for Sandwich ELISA - ABIN432398
Sucajtys-Szulc, Szolkiewicz, Swierczynski, Rutkowski: Up-regulation of Hnf1α gene expression in the liver of rats with experimentally induced chronic renal failure - A possible link between circulating PCSK9 and triacylglycerol concentrations. in Atherosclerosis 2016
Human APOC3 ELISA Kit for Competition ELISA - ABIN511216
Niu, Jiang, Xin, Jiang, Lin, Xuan: Lack of association between apolipoprotein C3 gene polymorphisms and risk of nonalcoholic fatty liver disease in a Chinese Han population. in World journal of gastroenterology : WJG 2014
intestinal apoC-III overexpression results in the secretion of smaller, less dense chylomicron particles along with reduced triacylglycerol secretion from the intestine
Aromatic residues in the C terminus of apolipoprotein C-III mediate lipid binding and LPL (show LCP1 ELISA Kits) inhibition
No evidence that APOC3 3'UTR (show UTS2R ELISA Kits) variant SstI modulates expression of liver/intestinal miRNAs in hypertriglyceridemia.
A rare variant in APOC3(rs138326449) has been associated with triglyceride, very low-density lipoprotein, and high-density lipoprotein levels, as well as risk of coronary heart disease. Effects are unlikely to be solely predictable by the action of APOC3 through LPL (show LCP1 ELISA Kits).
both human APOC3 A43T heterozygotes and mice expressing human APOC3 A43T display markedly reduced circulating apoC-III levels. In mice, this reduction is due to impaired binding of A43T apoC-III to lipoproteins and accelerated renal catabolism of free apoC-III.
Gene-level meta-analysis with other studies reporting burden signals at APOC3 provides robust evidence for a replicable cardioprotective rare variant aggregation
studied the associations of apoC-III, endothelial function and diabetic peripheral neuropathy
Plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9 (show PCSK9 ELISA Kits)), apolipoprotein C-III (apoC3) and small dense low density lipoprotein cholesterol (sdLDL-C) showed significant interactions with current dyslipidemias, and were predictive in the screening.
Novel sequencing techniques are detecting rare variants with larger effect sizes (eg, APOC3) , which may further improve on Cardiovascular disease risk prediction.
The APOC3 rs2070666 A allele is a risk factor for NAFLD independent of obesity, dyslipidemia, and PNPLA3 rs738409, and it might contribute to increased liver fat content in Chinese Han population.
ApoC-III inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR (show LDLR ELISA Kits)/LRP1 (show LRP1 ELISA Kits) axis
These data strongly suggest that intestinal apoC-III is not a FoxO1 (show FOXO1 ELISA Kits) target and support the idea that apoC-III is not regulated coordinately with hepatic apoC-III, and establishes another key aspect of apoC-III that is unique in the intestine from the liver.
APOC3, whose dysregulation is liable for hypertriglyceridemia, is not a predisposing factor for linking overnutrition to NAFLD (show TSC2 ELISA Kits) in obesity
Severe hypertriglyceridaemia resulting from ApoCIII overexpression promotes restenosis and atherosclerosis
Under conditions of islet insulin (show INS ELISA Kits) resistance, locally produced apoCIII is an important diabetogenic factor involved in impairment of beta-cell function.
decreased ApoAI synthesis might be accounted for the lower plasma HDL (show HSD11B1 ELISA Kits) level in ApoCIII transgenic mice
ApoCIII hyperactivates beta cell CaV1 (show CAV1 ELISA Kits) channels through SR-BI (show SCARB1 ELISA Kits)/beta1 integrin-dependent coactivation of PKA and Src (show SRC ELISA Kits).
Increased plasma APOC3 concentrations predispose mice to diet-induced nonalcoholic fatty liver and hepatic insulin (show INS ELISA Kits) resistance.
Glucose induces apoCIII transcription, which may represent a mechanism linking hyperglycemia, hypertriglyceridemia, and cardiovascular disease in type 2 diabetes.
gene polymorphisms in APOA5 (show APOA5 ELISA Kits) and APOC3 are associated with meat quality traits in Kele pigs
changes in apolipoprotein A-I (show APOA1 ELISA Kits) and apo (show C9orf3 ELISA Kits) C-III mRNA were reflected in their corresponding plasma levels
apoC-I (show APOC1 ELISA Kits) and apoC-III inhibit lipolysis by displacing LPL (show LPL ELISA Kits) from lipid emulsion particles. We also propose a role for these apolipoproteins in the irreversible inactivation of LPL (show LPL ELISA Kits) by factors such as angptl4 (show ANGPTL4 ELISA Kits).
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase\; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
, apolipoprotein C3
, apolipoprotein C-3
, apolipoprotein CIII