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Human APOC3 Protein expressed in Wheat germ - ABIN1345372
Makino, Noguchi, Takahashi, Matsumoto, Kubo, Yamada, Imoto, Ito, Osawa, Shibasaki, Uchida, Meno, Suzuki, Okubo, Arinami, Fujieda: Apolipoprotein A-IV is a candidate target molecule for the treatment of seasonal allergic rhinitis. in The Journal of allergy and clinical immunology 2010
Accumulating evidence indicates that apolipoprotein C-III is a multifaceted protein which not only regulates triglyceride metabolism, but also participates in the atherosclerotic lesion formation and several other pathological processes involved in atherosclerosis.
Our results showed that APOC3 was closely associated with the inflammatory process in ECs, and that this process was characterized by the increased expression of TNF-alpha (show TNF Proteins). Inflammatory processes further disrupted the tight junctions (TJs) between HUVECs by causing increased expression of JAM-1 (show F11R Proteins).
Transgenic mice expressing human APOC3in the C57BL/6J background have been described. The study found that hypertriglyceridemia per se is not an independent risk factor for beta cell dysfunction in ApoC3 transgenic mice.
ApoA-1 (show APOA1 Proteins) and ApoC-III may be used as differentiating and predictive markers for SCLC [ small cell lung cancer ].
The results of our meta-analysis point to a strong link between both APOA5 (show APOA5 Proteins) -1131T>C and APOC3 -455T>C polymorphisms and an increased risk of coronary heart disease .
HDL (show HSD11B1 Proteins)-apoCIII has a significant and positive association with coronary heart disease .
Low levels of APOA1 (show APOA1 Proteins), APOC3, and APOA4 (show APOA4 Proteins) are associated with risk of Alzheimer disease.
APOA5 (show APOA5 Proteins) -1131 T > C and APOC3 -455 T > C SNPs may play potent roles in the development and progression of coronary heart disease. (Meta-analysis)
D25V apolipoprotein C-III is a new human amyloidogenic protein and the first conferring cardioprotection.
the present findings reveal that High-altitude polycythemia -induced gastric mucosal lesion inspires the protection responses by up-regulating APOA4 (show APOA4 Proteins) and APOC3, and down-regulating GIF (show GIF Proteins).
Severe hypertriglyceridaemia resulting from ApoCIII overexpression promotes restenosis and atherosclerosis
Under conditions of islet insulin (show INS Proteins) resistance, locally produced apoCIII is an important diabetogenic factor involved in impairment of beta-cell function.
decreased ApoAI synthesis might be accounted for the lower plasma HDL (show HSD11B1 Proteins) level in ApoCIII transgenic mice
ApoCIII hyperactivates beta cell CaV1 (show CAV1 Proteins) channels through SR-BI (show SCARB1 Proteins)/beta1 integrin-dependent coactivation of PKA and Src (show SRC Proteins).
Increased plasma APOC3 concentrations predispose mice to diet-induced nonalcoholic fatty liver and hepatic insulin (show INS Proteins) resistance.
Glucose induces apoCIII transcription, which may represent a mechanism linking hyperglycemia, hypertriglyceridemia, and cardiovascular disease in type 2 diabetes.
PGC-1beta regulates plasma triglyceride metabolism through stimulating apolipoprotein C3 (APOC3) expression and elevating APOC3 levels in circulation
The apoC-III metabolism may contribute to dyslipidemia in CKD, and this requires further investigation.
ApoB (show APOB Proteins) lipoproteins that contain apoCIII increase THP-1 cell adhesion to ECs via PKCalpha (show PKCa Proteins) and RhoA (show RHOA Proteins)-mediated beta1-integrin activation.
oxidized fatty acids may act through an APOA5 (show APOA5 Proteins)/APOClll mechanism that contributes to lowering of TG levels other than PPAR (show PPARA Proteins)* induction
gene polymorphisms in APOA5 (show APOA5 Proteins) and APOC3 are associated with meat quality traits in Kele pigs
changes in apolipoprotein A-I (show APOA1 Proteins) and apo (show C9orf3 Proteins) C-III mRNA were reflected in their corresponding plasma levels
apoC-I (show APOC1 Proteins) and apoC-III inhibit lipolysis by displacing LPL (show LPL Proteins) from lipid emulsion particles. We also propose a role for these apolipoproteins in the irreversible inactivation of LPL (show LPL Proteins) by factors such as angptl4 (show ANGPTL4 Proteins).
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase\; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
, apolipoprotein C3
, apolipoprotein C-3
, apolipoprotein CIII