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anti-Human F2RL3 Antibodies:
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Human Monoclonal F2RL3 Primary Antibody for IHC, ELISA - ABIN1724706
Xie, Guo: Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. in The Journal of biological chemistry 2004
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Human Polyclonal F2RL3 Primary Antibody for WB - ABIN2801951
Kahn, Hammes, Botka, Coughlin: Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. in The Journal of biological chemistry 1998
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Human Monoclonal F2RL3 Primary Antibody for ELISA, WB - ABIN563904
Muehlschlegel, Perry, Liu, Fox, Smith, Lichtner, Collard, Shernan, Hartwig, Body, Hoffmeister: Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury. in American journal of hematology 2013
Human Polyclonal F2RL3 Primary Antibody for IF (p), IHC (p) - ABIN673224
Oláh, Kálmán, Tóth, Zvara, Sántha, Ivitz, Janka, Pákáski: Proteomic Analysis of Cerebrospinal Fluid in Alzheimer's Disease: Wanted Dead or Alive. in Journal of Alzheimer's disease : JAD 2014
Prospective study demonstrated that AHRR (show CYP1A1 Antibodies) and F2RL3 methylation levels had inverse relationships with self-reported smoking status and accurately discriminated for both current- and former- smoking. Moreover, methylation markers distinguished former smokers from never-smokers with high accuracy and significantly associated with an increased risk of lung cancer.
F2RL3 variants have the potential to markedly alter platelet PAR4 (show PAWR Antibodies) reactivity particularly after exposure to therapeutic PAR1 (show MARK2 Antibodies) antagonists.
these findings are the first to show that internalization of activated PAR4 (show PAWR Antibodies) is linked to proper ERK1/2 (show MAPK1/3 Antibodies) and Akt (show AKT1 Antibodies) activation.
an intracellular PAR4 C-terminal motif that regulates calcium signaling and beta-arrestin interactions, was identified.
the contribution of PAR1 (show MARK2 Antibodies) and PAR4 (show PAWR Antibodies) to thrombin (show F2 Antibodies)-mediated activation of the platelet fibrin receptor (GPIIbIIIa), is reported.
Suppression of PAR4 (show PAWR Antibodies) expression has no significant effect on the proliferation of SW620 cells, but can inhibit the migration of the cells.
Both GPIbalpha (show GP1BA Antibodies) and PAR4 (show PAWR Antibodies) are required for thrombin (show F2 Antibodies)-induced reactive oxygen species formation in human platelets.
Bladder PAR (show JTB Antibodies) activation elicits urothelial MIF (show AMH Antibodies) release and urothelial MIF (show AMH Antibodies) receptor signaling at least partly through CXCR4 (show CXCR4 Antibodies) to result in abdominal hypersensitivity without overt bladder inflammation
protease-activated receptor 4 and Trefoil factor 2 (show TFF2 Antibodies) are expressed in human colorectal cancer
The PAR4 (show PAWR Antibodies) expression and activation via intracellular signaling pathways and the role of PAR4 (show PAWR Antibodies) signaling pathways in the development and maintenance of pain.
Findings indicate that the energy-sensing LKB1 (show STK11 Antibodies)-AMPK (show PRKAA1 Antibodies) pathway regulates IGF1 (show IGF1 Antibodies) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R (show IGF1R Antibodies)-PKB (show AKT2 Antibodies) pathway.
These data suggest that nutrient availability dictates the mode of division and that LKB1 (show STK11 Antibodies)-AMPK (show PRKAA1 Antibodies) mediates this nutrient-driven effect on intestinal epithelial stem cell proliferation.
this study identified the molecular mechanism of increased angiogenesis and tumor growth with LKB1 (show STK11 Antibodies) deficiency
These results suggest that although physiologic LKB1 (show STK11 Antibodies) expression exerts a potent pro-survival effect in lymphocytes, LKB1 (show STK11 Antibodies) inactivation nonetheless facilitates transformation of B, but not T, lymphocytes.
These results suggest that the LKB1 (show STK11 Antibodies)-AMPK (show PRKAA1 Antibodies)-FoxO1 (show FOXO1 Antibodies) signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.
Lkb1 (show STK11 Antibodies) activates the Notch (show NOTCH1 Antibodies) signaling pathway, which subsequently increases Pax7 (show PAX7 Antibodies) expression and promotes self-renewal and proliferation while inhibiting differentiation. Mechanistic studies reveal that Lkb1 (show STK11 Antibodies) regulates Notch (show NOTCH1 Antibodies) activation through AMPK (show PRKAA1 Antibodies)-mTOR (show FRAP1 Antibodies) pathway in myoblasts.
mitochondrial dysfunction triggers LKB1 (show STK11 Antibodies)-mediated AMPK (show PRKAA1 Antibodies) activation, which stimulates Sirt2 (show SIRT2 Antibodies) phosphorylation, leading to activation of mTOR (show FRAP1 Antibodies)-RAPTOR (show RPTOR Antibodies) and Glut1 (show SLC2A1 Antibodies)-mediated glucose uptake.
these data demonstrated that LKB1 (show STK11 Antibodies)/AMPK (show PRKAA1 Antibodies) signaling pathway activation improved the survival of diabetic mice complicated with endotoxemia. Thus, LKB1 (show STK11 Antibodies)/AMPK (show PRKAA1 Antibodies) signaling pathway may serve as a potentially useful therapeutic target for severe infection in diabetic patients.
Data show that the serine/threonine kinase (show CDK4 Antibodies) LKB1 (show STK11 Antibodies) regulates mitochondrial calcium uniporter (MCU (show MCU Antibodies))-expression, mitochondria-dependent Ca2 (show CA2 Antibodies)+ clearance, and thereby, presynaptic release properties.
LKB1 (show STK11 Antibodies) deficiency in LKB1 (show STK11 Antibodies)(Pax2 (show PAX2 Antibodies)) CKO mice disrupted hair cell planar polarity during embryonic development. The results suggest that LKB1 (show STK11 Antibodies) is required in planar cell polarity formation in cochlear hair cells in mice.
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.
proteinase-activated receptor 4
, coagulation factor II (thrombin) receptor-like 3
, coagulation factor II (thrombin)
, protease-activated receptor-4
, thrombin receptor-like 3
, coagulation factor II receptor-like 3
, protease-activated receptor 4
, LKB1 short isoform
, liver kinase B1 homolog
, serine/threonine-protein kinase 11
, serine/threonine-protein kinase LKB1
, serine/threonine-protein kinase STK11