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STAT3 (show STAT3 ELISA Kits) expression is upregulated in both HBV- and HCV-related hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)), while hexokinase II (HK-II (show HK2 ELISA Kits)) is predominantly upregulated and correlated to STAT3 (show STAT3 ELISA Kits) in HBV-related HCC (show FAM126A ELISA Kits)
Russe type hereditary motor and sensory neuropathy belongs to the most frequent types of hereditary neuropathy in the Czech Republic, which affects Roma and is caused by a HK1 (show KCNA4 ELISA Kits) mutation.
Data suggest that overexpression of hexokinase 1 (HK1) may act as a significant biomarker of poor prognosis for patients with colorectal cancer (CRC (show CALR ELISA Kits)).
4-hydroxytamoxifen resistance in breast cancer cells is suppressed by curcumin, which targets the SLUG (show SNAI2 ELISA Kits)/Hexokinase 2 (show HK2 ELISA Kits) pathway
Our results suggest that overexpression of PKM2 and HK1 (show KCNA4 ELISA Kits), especially the latter, significantly associates with lymphatic metastasis, advanced clinical staging and unfavorable prognosis in gastric cancer.
HK1 (show KCNA4 ELISA Kits) and HK2 (show HK2 ELISA Kits) expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 (show HK3 ELISA Kits) expression level was significantly increased in 60% of samples.
Data indicate a missense mutation in hexokinase 1 (HK1) c.2539G > A, p.Glu847Lys, tracking with disease in all affected family members.
HK1 expression is highly enriched in neurons compared to astrocytes in the cerebral cortex.
HK-1 (show KCNA4 ELISA Kits) plays a non-metabolic role in HIV-1 infected macrophages by binding to mitochondria thereby maintaining mitochondrial integrity.
The present study was designed to evaluate the involvement of hexokinase and CPT-1 (show CPT1A ELISA Kits) in the cell growth and proliferation of human prostate cancer cell lines, PC3 (show PCSK1 ELISA Kits), and LNCaP-FGC-10.
Hexokinase expression is highly enriched in neurons compared to astrocytes.
The interaction of DREAM with hexokinase I may be important in the regulation of neuronal apoptosis.
Standard chow affects body weight, heart weight and HK activity and HKI (show TAC4 ELISA Kits) expression in the heart, without altering HKII (show HK2 ELISA Kits) expression.
HK1S is tethered in the principal piece region by PFKMS, which in turn is bound tightly to GSTM5 (show GSTM5 ELISA Kits) in the fibrous sheath of sperm.
HK-1 alone was sufficient to induce the activation of MAPKs and the expression of Blimp-1 (show PRDM1 ELISA Kits) and Xbp-1 (show XBP1 ELISA Kits) in B cells.
The comprehensive sequencing analysis and fine mapping approximately 26 kb of fully characterised sequence spanning the upstream exons of Hexokinase 1 (HK1), is reported.
A new spontaneous mutation in the A/J inbred mouse strain, downeast anemia (dea), causes severe hemolytic anemia with extensive tissue iron deposition and marked reticulocytosis
the Hexokinase-mitochondria interaction mediated by Akt (show AKT1 ELISA Kits) has a role in inhibiting apoptosis but does not require Bax (show BAX ELISA Kits) and Bak (show BAK1 ELISA Kits)
RanBP2 (show RANBP2 ELISA Kits) associates in vitro and in vivo and colocalizes with the mitochondrial metallochaperone, Cox11, and the pacemaker of glycolysis, hexokinase type I (HKI) via its leucine-rich domain.
Between these two strategies to activate glycogen (show GYS1 ELISA Kits) deposition in the absence of GK, embryonic livers choose to express massive levels of HKI (show TAC4 ELISA Kits) and HKII (show HK2 ELISA Kits).
role in cell death mediated by myo (show SYNPO2 ELISA Kits)-inositol accumulation
The structure of HXK1 was determined both in its inactive unliganded form and in its active glucose-bound form at resolutions of 1.8 and 2.0 A, respectively.
The CO2 metabolism of the gin2-1 mutation in A. thaliana is reported.
HXK1 mediated stimulation of NRT2.1 expression.
Data suggest that regulation of NIA1 and NIA2 nitrate reductases (NR) activity by sugars does not involve HXK1 as a glucose sensor.
Overexpression of AtHXK1 inhibits growth and accelerates leaf senescence under normal growth conditions.
HKL1 (show ZNF354A ELISA Kits) and HXK1 can interact, these two proteins likely form a critical node in Glc signaling that mediates overlapping, but also distinct, cellular responses to Glc and ethylene treatments.
HXK1-dependent glucose signaling uncoupled from other plant stress and defense hormone signaling has a central regulatory role in early seedling establishment.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus\; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.
, hexokinase type I
, hexokinase 1
, brain form hexokinase
, glycolytic enzyme
, downeast anemia
, hexokinase, tumor isozyme
, hexokinase I