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Human Hexokinase 1 Primary Antibody for SDS - ABIN668037
Furuta, Nishi, Le Beau, Fernald, Yano, Bell: Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. in Genomics 1997
Show all 2 references for ABIN668037
Data suggest that overexpression of hexokinase 1 (HK1) may act as a significant biomarker of poor prognosis for patients with colorectal cancer (CRC (show CALR Proteins)).
4-hydroxytamoxifen resistance in breast cancer cells is suppressed by curcumin, which targets the SLUG (show SNAI2 Proteins)/Hexokinase 2 (show HK2 Proteins) pathway
Our results suggest that overexpression of PKM2 and HK1 (show KCNA4 Proteins), especially the latter, significantly associates with lymphatic metastasis, advanced clinical staging and unfavorable prognosis in gastric cancer.
HK1 (show KCNA4 Proteins) and HK2 (show HK2 Proteins) expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 (show HK3 Proteins) expression level was significantly increased in 60% of samples.
Data indicate a missense mutation in hexokinase 1 (HK1) c.2539G > A, p.Glu847Lys, tracking with disease in all affected family members.
HK1 expression is highly enriched in neurons compared to astrocytes in the cerebral cortex.
HK-1 (show KCNA4 Proteins) plays a non-metabolic role in HIV-1 infected macrophages by binding to mitochondria thereby maintaining mitochondrial integrity.
The present study was designed to evaluate the involvement of hexokinase and CPT-1 (show CPT1A Proteins) in the cell growth and proliferation of human prostate cancer cell lines, PC3 (show PCSK1 Proteins), and LNCaP-FGC-10.
HK1 (show KCNA4 Proteins) is expressed in retina, with two abundant isoforms expressed at similar levels. The Glu847Lys mutation is located at a highly conserved position in the protein, outside the catalytic domains.
Here, we identified HK1 (show KCNA4 Proteins) as a novel causative gene for adRP (show PLIN2 Proteins). This is the first report that associates the glucose metabolic pathway with human retinal degenerative disease, suggesting a potential new disease mechanism.
Hexokinase expression is highly enriched in neurons compared to astrocytes.
The interaction of DREAM with hexokinase I may be important in the regulation of neuronal apoptosis.
Standard chow affects body weight, heart weight and HK activity and HKI expression in the heart, without altering HKII (show HK2 Proteins) expression.
HK1S is tethered in the principal piece region by PFKMS, which in turn is bound tightly to GSTM5 (show GSTM5 Proteins) in the fibrous sheath of sperm.
HK-1 alone was sufficient to induce the activation of MAPKs and the expression of Blimp-1 (show PRDM1 Proteins) and Xbp-1 (show XBP1 Proteins) in B cells.
The comprehensive sequencing analysis and fine mapping approximately 26 kb of fully characterised sequence spanning the upstream exons of Hexokinase 1 (HK1), is reported.
A new spontaneous mutation in the A/J inbred mouse strain, downeast anemia (dea), causes severe hemolytic anemia with extensive tissue iron deposition and marked reticulocytosis
the Hexokinase-mitochondria interaction mediated by Akt (show AKT1 Proteins) has a role in inhibiting apoptosis but does not require Bax (show BAX Proteins) and Bak (show BAK1 Proteins)
RanBP2 associates in vitro and in vivo and colocalizes with the mitochondrial metallochaperone, Cox11 (show COX11 Proteins), and the pacemaker of glycolysis, hexokinase type I (HKI) via its leucine-rich domain.
Between these two strategies to activate glycogen (show GYS1 Proteins) deposition in the absence of GK, embryonic livers choose to express massive levels of HKI and HKII (show HK2 Proteins).
role in cell death mediated by myo-inositol accumulation
The structure of HXK1 was determined both in its inactive unliganded form and in its active glucose-bound form at resolutions of 1.8 and 2.0 A, respectively.
The CO2 metabolism of the gin2-1 mutation in A. thaliana is reported.
HXK1 mediated stimulation of NRT2.1 expression.
Data suggest that regulation of NIA1 and NIA2 nitrate reductases (NR) activity by sugars does not involve HXK1 as a glucose sensor.
Overexpression of AtHXK1 inhibits growth and accelerates leaf senescence under normal growth conditions.
HKL1 (show ZNF354A Proteins) and HXK1 can interact, these two proteins likely form a critical node in Glc signaling that mediates overlapping, but also distinct, cellular responses to Glc and ethylene treatments.
HXK1-dependent glucose signaling uncoupled from other plant stress and defense hormone signaling has a central regulatory role in early seedling establishment.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus\; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.
, hexokinase type I
, hexokinase 1
, brain form hexokinase
, glycolytic enzyme
, downeast anemia
, hexokinase, tumor isozyme
, hexokinase I