Browse our anti-NADPH Oxidase 4 (NOX4) Antibodies

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anti-NADPH Oxidase 4 Antibodies (NOX4)
On are 177 NADPH Oxidase 4 (NOX4) Antibodies from 18 different suppliers available. Additionally we are shipping NADPH Oxidase 4 Kits (15) and NADPH Oxidase 4 Proteins (12) and many more products for this protein. A total of 211 NADPH Oxidase 4 products are currently listed.
AI648021, KOX, KOX-1, NOX4, RENOX

Most Popular Reactivities for anti-NADPH Oxidase 4 (NOX4) Antibodies

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Top referenced anti-NADPH Oxidase 4 Antibodies

  1. Cow (Bovine) Polyclonal NOX4 Primary Antibody for ICC, IHC (fro) - ABIN189715 : Maranchie, Zhan: Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma. in Cancer research 2005 (PubMed)
    Show all 46 references for 189715

  2. Human Polyclonal NOX4 Primary Antibody for IHC (p), WB - ABIN657946 : Manea, Tanase, Raicu, Simionescu: Transcriptional regulation of NADPH oxidase isoforms, Nox1 and Nox4, by nuclear factor-kappaB in human aortic smooth muscle cells. in Biochemical and biophysical research communications 2010 (PubMed)
    Show all 3 references for 657946

  3. Human Polyclonal NOX4 Primary Antibody for FACS, ICC - ABIN258606 : Basuroy, Bhattacharya, Leffler, Parfenova: Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. in American journal of physiology. Cell physiology 2009 (PubMed)
    Show all 2 references for 258606

  4. Human Polyclonal NOX4 Primary Antibody for IHC, IHC (p) - ABIN409683 : Zhang, Liu, Hu: Inhibiting cancer metastasis via targeting NAPDH oxidase 4. in Biochemical pharmacology 2013 (PubMed)

  5. Dog (Canine) Polyclonal NOX4 Primary Antibody for IF (p), IHC (p) - ABIN737526 : Khan, Byer, Khan: Exposure of Madin-Darby canine kidney (MDCK) cells to oxalate and calcium oxalate crystals activates nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase. in Urology 2014 (PubMed)

  6. Mouse (Murine) Polyclonal NOX4 Primary Antibody for IHC, WB - ABIN3023201 : Wingler, Wünsch, Kreutz, Rothermund, Paul, Schmidt: Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo. in Free radical biology & medicine 2001 (PubMed)

  7. Human Polyclonal NOX4 Primary Antibody for IF (p), IHC (p) - ABIN702610 : Kashiwabara, Ambe, Nakagawa, Watanabe: Immunohistochemical localization of Nox in mouse circumvallate papillae. in Tissue & cell 2015 (PubMed)

More Antibodies against NADPH Oxidase 4 Interaction Partners

Human NADPH Oxidase 4 (NOX4) interaction partners

  1. NOX2 (show CYBB Antibodies), NOX4, and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 (show ANGPT1 Antibodies) signaling and angiogenic responses in endothelial cells.

  2. Mechanistically, HO-1 (show HMOX1 Antibodies) induction by all CRLPs requires NADPH oxidase 4, with PUFA-containing particles additionally dependent upon mitochondrial reactive oxygen species.These studies define new molecular pathways coupling endothelial cell activation by model CMRs with adaptive regulation of Nrf2 (show GABPA Antibodies)-dependent HO-1 (show HMOX1 Antibodies) expression

  3. NOX4 knockout cell lines showed reduced cell proliferation with an increase of sub-G1 cell population and the decrease of S/G2 (show STRN3 Antibodies)/M population, and resulted in a dramatic decrease in invadopodium formation and the invasive activity. NOX4 deficiency caused a decrease in focal adhesions and cell migration in HeLa cells. The results suggest that NOX4 is required for both efficient proliferation and invasion of HeLa cells.

  4. Thioredoxin (show TXN Antibodies) attenuates oxidized low-density lipoprotein induced oxidative stress in human umbilical vein endothelial cells by reducing NOX2 (show CYBB Antibodies)-NOX4 activity.

  5. Nox4-derived H2O2 in part activates Nox2 (show CYBB Antibodies) to increase mitochondrial ROS (show ROS1 Antibodies) via pSer36-p66Shc (show SHC1 Antibodies), thereby enhancing VEGFR2 (show KDR Antibodies) signaling and angiogenesis in endothelial cells.

  6. TGF-beta1 (show TGFB1 Antibodies) increases NADPH oxidase 4 (NOX4) mRNA and protein expression in normal human lung fibroblasts (NHLFs) and causes nuclear export of HDAC4 (show HDAC4 Antibodies).

  7. Nox4 should contribute to the pathological processes insubarachnoid hemorrhage(SAH (show ACSM3 Antibodies))-induced early brain injury (EBI (show TBL1X Antibodies)), and there was not an overlay effect of Nox2 (show CYBB Antibodies) inhibition and Nox4 inhibition on preventing SAH (show ACSM3 Antibodies)-induced EBI (show TBL1X Antibodies).

  8. TGFbeta1 (show TGFB1 Antibodies) was found to induce Nox4 mRNA expression and total collagen release by these cells (P < 0.05; n = 4), and both responses are blocked by Smad3 (show SMAD3 Antibodies) inhibitor SIS3. Suppressing Nox4 gene transcription with Adv (show AVIL Antibodies)-Nox4i completely attenuated TGFbeta1 (show TGFB1 Antibodies)-stimulated H2O2 release and collagen production by conjunctival fibroblasts

  9. CD44V6 is part of a positive-feedback loop with TGFbeta1 (show TGFB1 Antibodies)/TGFbetaRI signaling that acts to increase NOX4/ROS (show ROS1 Antibodies) production, which is required for myofibroblast differentiation, myofibroblast differentiation, myofibroblast extracellular matrix production, myofibroblast invasion, and myofibroblast contractility.

  10. Endoplasmic reticulum stress triggers a localized signaling module on the ER surface involving Nox4-dependent calcium mobilization, which directs local Ras activation through ER-associated, calcium-responsive RasGRF.

Cow (Bovine) NADPH Oxidase 4 (NOX4) interaction partners

  1. Peroxide derived from superoxide generated by Nox4 appears to maintain a basal relaxation in bovine pulmonary arteries under normoxic conditions, which is removed under hypoxia leading to hypoxic pulmonary vasoconstriction.

Rabbit NADPH Oxidase 4 (NOX4) interaction partners

  1. proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase (show NOX1 Antibodies) activity, as well as increases in Nox4 isoform and protein disulfide isomerase (show P4HB Antibodies) mRNA expression

Mouse (Murine) NADPH Oxidase 4 (NOX4) interaction partners

  1. NOX4-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 (show EDN1 Antibodies) production.

  2. CYLD (show CYLD Antibodies) contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 and may play a role in vascular remodeling.

  3. Data suggests that ROS (show ROS1 Antibodies) produced during primitive endoderm differentiation is dependent in part on increased NOX1 (show NOX1 Antibodies) and NOX4 levels, which is under the control of GATA6 (show GATA6 Antibodies). Furthermore, these results suggest that the combined activity of multiple NOX proteins is necessary for the differentiation of F9 cells to primitive endoderm.

  4. Nox4 is upregulated in pericytes in peri (show POSTN Antibodies)-infarct areas after acute brain ischemia and may enhance blood-brain barrier breakdown through activation of NFkappaB and matrix metalloproteinase 9 (show MMP9 Antibodies), thereby causing enlargement of infarct volume.

  5. Deficiency of NOX4 resulted in reduced expression of carnitine palmitoyltransferase 1A (CPT1A (show CPT1A Antibodies)), which is a key mitochondrial enzyme in the fatty acid oxidation (FAO) pathway. The reduced FAO resulted in less activation of the nucleotide-binding domain, leucine-rich-repeat-containing receptor (NLR (show CXCR5 Antibodies)), pyrin-domain-containing 3 (NLRP3 (show NLRP3 Antibodies)) inflammasome in macrophages.

  6. NOX4- and NOX1 (show NOX1 Antibodies)-derived ROS (show ROS1 Antibodies) contribute to atherosclerosis in the aortic sinus of diabetic ApoE (show APOE Antibodies) knockout mice.

  7. CD44V6 is part of a positive-feedback loop with TGFbeta1 (show TGFB1 Antibodies)/TGFbetaRI signaling that acts to increase NOX4/ROS (show ROS1 Antibodies) production, which is required for myofibroblast differentiation, myofibroblast differentiation, myofibroblast extracellular matrix production, myofibroblast invasion, and myofibroblast contractility.

  8. Nox4 mitigates cerebral artery structural changes in a murine model of Marfan syndrome.

  9. Data show that pan (show SUPT6H Antibodies)-NOX-inhibitor APX (show SHROOM1 Antibodies)-115 treatment decreased NADPH oxidase (show NOX1 Antibodies) (Nox) Nox1 (show NOX1 Antibodies), Nox2 (show CYBB Antibodies), and Nox4 protein expression in the kidney.

  10. enhancement of mitochondrial bioenergetics as well as the increase in mitochondrial proteins in Nox4-deficient lung fibroblasts is inhibited by silencing of nuclear factor erythroid-derived 2-like 2 (Nrf2 (show NFE2L2 Antibodies)), supporting a key role for Nrf2 (show NFE2L2 Antibodies) in control of mitochondrial biogenesis

Pig (Porcine) NADPH Oxidase 4 (NOX4) interaction partners

  1. MRTF down-regulation/inhibition suppresses TGFbeta (show TGFB1 Antibodies)/contact disruption-provoked Nox4 protein and mRNA expression, Nox4 promoter activation, and reactive oxygen species production.

  2. Nox4 NADPH oxidase (show NOX1 Antibodies) mediates oxidative stress and apoptosis caused by TNF-alpha (show TNF Antibodies) in cerebral vascular endothelial cells.

  3. Nox4 NADPH oxidase (show NOX1 Antibodies)-derived reactive oxygen species also initiate a cell survival mechanism by increasing production of carbon monoxide by constitutive heme oxygenase-2 (show HMOX2 Antibodies).

NADPH Oxidase 4 (NOX4) Antigen Profile

Antigen Summary

This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with NADPH Oxidase 4 (NOX4)

  • NADPH oxidase 4 (NOX4) antibody
  • NADPH oxidase 4 (nox4) antibody
  • NADPH oxidase 4 (PTRG_09562) antibody
  • NADPH oxidase 4 (Nox4) antibody
  • AI648021 antibody
  • KOX antibody
  • KOX-1 antibody
  • NOX4 antibody
  • RENOX antibody

Protein level used designations for anti-NADPH Oxidase 4 (NOX4) Antibodies

NADPH oxidase 4 , predicted NADPH oxidase-4 , kidney oxidase-1 , kidney superoxide-producing NADPH oxidase , renal NAD(P)H-oxidase , KOX-1 , superoxide-generating NADPH oxidase 4 , kox-1

419012 Gallus gallus
619226 Ciona intestinalis
705931 Macaca mulatta
735636 Pan troglodytes
6347852 Pyrenophora tritici-repentis Pt-1C-BFP
50507 Homo sapiens
378474 Bos taurus
100034665 Ovis aries
100339697 Oryctolagus cuniculus
50490 Mus musculus
85431 Rattus norvegicus
100523323 Sus scrofa
485144 Canis lupus familiaris
100171782 Pongo abelii
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