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Findings suggest the underlying mechanism of upstream transcription factor 1 (USF1) in papillary thyroid cancer (PTC (show F9 Proteins)) development.
SNP (single-nucleotide polymorphism) alle (show BAAT Proteins)les that reduced USF1 mRNA expression also displayed a beneficial cardiometabolic profile, featuring improved insulin sensitivity, (show BAAT Proteins) a favorable lipid profile, and reduced atherosc (show BAAT Proteins)lerosis
USF1 gene can take part in basal transcription regulation of the human A3G gene in hepatocyte, and the identified E-box represented a binding site for the USF1.
A trend of increasing triglycerides levels in relation to the C allele dose of rs2516839 SNP was observed. The synergistic effect of cigarette smoking and C allele carrier state on CAD risk was found.
Rta (show RBM9 Proteins) autoregulates BRLF1 transcription via its interaction with USF1 on E1.
Results show that the USF1 and APOA5 (show APOA5 Proteins) polymorphisms are associated with Familial combined hyperlipidemia and that the S19W SNP in the APOA5 (show APOA5 Proteins) gene is associated to the disease independently of total cholesterol, triglycerides and body mass index.
The carriers of minor alleles of rs2516839 (C) and rs1556259 (G) of USF1 gene had decreased USF1 expression in atherosclerotic plaques as compared to non-carriers.
Our results provided a new insight into susceptibility of USF1 variant with male infertility. rs11204546 of OR2W3 (show OR2W3 Proteins) and rs11677854 of GTF2A1L (show GTF2A1L Proteins) might be additional valuable molecular predictive markers
CK2 (show CSNK2A1 Proteins) phosphorylation of USF1 modulates two functionally important properties of USF1, namely hetero-dimerization and transactivation.
Further studies may be needed to validate our results and gain insights into the pathological mechanism of USF1 gene in the HCC (show FAM126A Proteins) tumorigenesis.
study demonstrates that upstream transcription factor 1 (USF1) is a maternally derived transcription factor required for bovine early embryonic development
bovine upstream stimulatory factor 1 and 2 have roles regulating the prostaglandin G/H synthase-2 (show PTGS2 Proteins) promoter in granulosa cells [USF1/USF2 (show USF2 Proteins)]
Mice lacking Usf1 displayed increased BAT (show BAAT Proteins)-facilitated, diet-induced thermogenesis with up-regulation of mitochondrial respiratory chain complexes, as well as increased BAT (show BAAT Proteins) activity even at thermoneutrality and after BAT (show BAAT Proteins) sympathectomy
USF1 exclusively bound to the CACGTG E-box motifs in the brain cortex neuron proximal promoter regions. Importantly, functional annotation of the USF1-binding targets revealed an enrichment of genes related to lysosomal functions.
Propose that USF1 is an important modulator of molecular and behavioral circadian rhythms in mammals via DNA-binding of the CLOCK:BMAL1 complex.
USF1 but not USF2 (show USF2 Proteins) supports OPN (show SPP1 Proteins) expression in LRP6 (show LRP6 Proteins)-VKO vascular smooth muscle lineage, and immunoprecipitation confirmed increased USF1 association with OPN (show SPP1 Proteins) chromatin.
They underscore the new role of USF1 and give new clues of how p53 (show TP53 Proteins) loss of function can occur in any cell type.
Pdx1 (show PDX1 Proteins), USF1 and USF2 (show USF2 Proteins) co-ordinately regulate Alx3 (show ALX3 Proteins) gene expression in pancreatic beta-cells.
USF1-centered regulatory networks were further confirmed by ChIP assays.
studies define the critical opposing functions of DREAM and USF1 in inhibiting and inducing A20 (show TNFAIP3 Proteins) expression
AGTRAP (show AGTRAP Proteins) expression is regulated by USF1 and USF2 (show USF2 Proteins)
USF1 transactivates GATA5 expression by binding to the E-box in its promoter
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21.
upstream transcription factor 1 usf1
, upstream transcription factor 1
, upstream stimulatory factor 1
, major late transcription factor 1
, class B basic helix-loop-helix protein 11
, upstream stimulatory factor 1a
, Upstream stimulatory factor 1 (Major late transcription factor 1)