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Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin (show CTNNB1 Proteins)
Taken together, our results demonstrated the deregulation of GAS2 in both AML (show RUNX1 Proteins) and ALL and the requirement of GAS2-Calpain2 axis for the growth of leukemic cells.
Truncated HBx deregulates cell growth via direct silencing of GAS2 and thereby provides a survival advantage for pre-neoplastic hepatocytes to facilitate cancer development via TP53 (show TP53 Proteins) signaling.
GAS2 is up-regulated in chronic myeloid leukemia (show BCL11A Proteins) cells.
Studies have identified a Gas2/calpain-dependent mechanism by which ICSBP (show IRF8 Proteins) influences beta-catenin (show CTNNB1 Proteins) activity in myeloid leukemia (show BCL11A Proteins).
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified.
growth arrest-specific protein 2
, growth arrest-specific 2