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Results suggested that high expression of SATB1 is significantly correlated with poor differentiation of CRC (show CALR ELISA Kits). SATB1 might promote the epithelial-mesenchymal transition by increasing the aberrant expression of beta-catenin (show CTNNB1 ELISA Kits).
Logistic regression revealed that four variants in NR3C1 (show NR3C1 ELISA Kits) and SATB1 were significantly associated with lung cancer risk after false discovery rate (FDR) correction [For NR3C1 (show NR3C1 ELISA Kits), rs9324921: odds ratio (OR)=1.23, P for FDR=0.029; rs12521436: OR=0.85, P for FDR=0.040; rs4912913: OR=1.17, P for FDR=0.040; For SATB1, rs6808523: OR=1.33, P for FDR=0.040].
modulation of epithelial-mesenchymal transition by SATB1 may contribute to prostate cancer metastasis.
Tumor-driven, unremitting expression of Satb1 in activated Zbtb46+ inflammatory dendritic cells that infiltrate ovarian tumors results in an immunosuppressive phenotype characterized by increased secretion of tumor-promotin (show LGALS1 ELISA Kits)g Galecti (show IL6 ELISA Kits)n-1 and IL-6.
High expression of SATB1 is associated with colorectal cancer.
radiation decreases SATB1 expression and sensitizes cancer cells to confer clinical benefit of patients, suggesting that SATB1 is predictive of response to preoperative RT and clinical outcome in rectal cancer.
Findings indicate that high Ki67 (show MKI67 ELISA Kits) antigen/ SATB1 protein ratio was an independent predictor of worse overall survival (OS), while Ki67 (show MKI67 ELISA Kits) and SATB1 did not reach statistical significance as single predictors.
SATB1 reprograms the expression of tumor growth- and metastasis-associated genes to promote tumorigenesis and functionally overlaps with Wnt (show WNT2 ELISA Kits) signaling critical for colorectal cancer tumorigenesis.
SATB1 as a Dual Regulator of Anti-Apoptotic BCL2 (show BCL2 ELISA Kits) and Pro-Apoptotic NOXA (show PMAIP1 ELISA Kits) Genes
SATB1 protein expression showed an increasing trend in advancing stages of breast cancer development.
Tumor-driven, unremitting expression of Satb1 in activated Zbtb46+ inflammatory DCs that infiltrate ovarian tumors results in an immunosuppressive phenotype characterized by increased secretion of tumor-promoting Galectin-1 (show LGALS1 ELISA Kits) and IL-6 (show IL6 ELISA Kits).
These results suggest that SATB1 plays an essential role in establishment of immune tolerance.
Data show that RNA binding protein HuD and special adenine-thymine (AT)-rich DNA-binding protein 1 (SATB1) form a positive regulatory loop that enhances NeuroD1 protein transcription and subsequent neuronal differentiation.
Fluorosed mouse ameloblasts have increased SATB1 retention and Galphaq (show GNAQ ELISA Kits) activity.
The results indicated that the expression of SATB1 in both mRNA and protein levels was significantly decreased after cells transferred with siRNA sequence for 48 h, the proliferation of MF9 cells was significantly inhibited.
SATB1 binds to the ASE (show ARSE ELISA Kits) and Rag promoters, facilitating inclusion of Rag2 (show RAG2 ELISA Kits) in the chromatin hub and the loading of RNA polymerase II to both the Rag1 (show RAG1 ELISA Kits) and Rag2 (show RAG2 ELISA Kits) promoters.
SATB1 is indispensable for lymphocyte differentiation and stem cell development. (Review)
The ubiquitin-like domain-CUT repeat-like tandem of SATB1 are required for DNA binding.
Satb1 is a regulator that promotes hematopoietic stem cells quiescence and represses lineage commitment.
SATB1 as a critical regulator of interneuron maturation and terminal differentiation in the mammalian cortex.
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.
SATB homeobox 1
, special AT-rich sequence binding protein 1
, AT-rich binding protein-1
, DNA-binding protein SATB1-like
, DNA-binding protein SATB1
, special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)
, special AT-rich sequence-binding protein 1