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Browse our TFAP2A Proteins (TFAP2A)

Full name:
Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) Proteins (TFAP2A)
On are 9 Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A) Proteins from 5 different suppliers available. Additionally we are shipping TFAP2A Antibodies (186) and TFAP2A Kits (3) and many more products for this protein. A total of 201 TFAP2A products are currently listed.
Albp, Ap-2, AP-2alpha, Ap2, ap2a, AP2alpha, Ap2tf, BOFS, cb93, fb83f04, fc31a07, Tcfap2a, TFAP2, TFAP2A, tfap2a-a, tfap2alpha, wu:fb83f04, wu:fc31a07, XAP-2, xap2
list all proteins Gene Name GeneID UniProt
TFAP2A 79451  
TFAP2A 7020 P05549
TFAP2A 21418 P34056

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TFAP2A Proteins (TFAP2A) by Origin

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Top referenced TFAP2A Proteins

  1. Human TFAP2A Protein expressed in Wheat germ - ABIN1322523 : Zhang, Li, Shibahara, Takahashi: Synergistic activation of the human adrenomedullin gene promoter by Sp1 and AP-2alpha. in Peptides 2008 (PubMed)

More Proteins for TFAP2A Interaction Partners

Xenopus laevis Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A) interaction partners

  1. AP2a initiates neural border patterning and is sufficient to elicit a neural border-like pattern in neuralized (show NEURL Proteins) ectoderm.

Zebrafish Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A) interaction partners

  1. these data support a model in which Tfap2a, acting through Bmp7a (show BMP7 Proteins), modulates Fgf and Notch (show NOTCH1 Proteins) signaling to control the duration, amount and speed of SAG (show SAG Proteins) neural development.

  2. Prdm1a directly binds and activates a tfap2a enhancer at the NPB

  3. Low Bmp activates expression of the transcription factor Tfap2a as part of a gene regulatory network that coordinates development of neural crest, preplacodal ectoderm and individual placodes in zebrafish.

  4. tfap2a and foxd3 (show FOXD3 Proteins) are expressed during gastrulation prior to neural crest induction in distinct, complementary, domains; tfap2a is expressed in the ventral non-neural ectoderm and foxd3 (show FOXD3 Proteins) in the dorsal mesendoderm and ectoderm

  5. These results reveal that mutations in TFAP2A are associated with a wide range of eye phenotypes and that hypomorphic tfap2a mutations can increase the risk of developmental defects arising from mutations at other loci.

  6. These findings reveal that Tfap2 activity, mediated redundantly by Tfap2a and Tfap2e (show TFAP2E Proteins), promotes melanophore differentiation in parallel with Mitf (show MITF Proteins) by an effector other than Kit.

  7. Results demonstrate that tfap2a is required for early steps in neural crest development and for the survival of a subset of neural crest derivatives.

  8. data show that hindbrain noradrenergic neurons of the locus coeruleus and the posterior groups both require Tfap2a to establish their noradrenergic identity

  9. Ap-2alpha regulates multiple steps of melanophore development, and is required for development of other neuronal and non-neuronal neural crest derivatives.

  10. function in the neural crest in specification of subpopulations of pigment cells and segmental patterning of the pharyngeal skeleton through the regulation of Hox (show MSH2 Proteins) genes

Human Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A) interaction partners

  1. AP-2a is an important transcription factor of DEK (show DEK Proteins) expression, which is correlated with the methylation level of the DEK (show DEK Proteins) core promoter in hepatocellular carcinoma .

  2. AP-2alpha expression has a role in human hepatocellular cancer by regulating signaling to affect cell growth and migration

  3. Hepatitis B virus X protein is able to elevate the expression of SPHK1 (show SPHK1 Proteins) in hepatoma cells by upregulating transcription factor AP2 alpha.

  4. Results indicate that AP-2alpha activates COX-2 expression to promote NPC (show NPC1 Proteins) growth.

  5. The AP-2alpha transcription factor may play an important role in suppressing glioma progression.

  6. TFAP2A might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.

  7. INHA (show INHA Proteins) gene expression is upregulated by cAMP via CRE in human trophoblasts, and TFAP2 regulates this expression by interacting with CRE.

  8. Human melanomas display higher than normal CpG DNA methylation (show HELLS Proteins) at the TFAP2A promoter.Aberrant CpG DNA methylation (show HELLS Proteins) as an epigenetic mark associated with TFAP2A silencing in human melanoma.

  9. ETS1 (show ETS1 Proteins) induction of syncytiotrophoblast marker genes likely results in part from transactivation by activator protein-2alpha.

  10. Direct sequencing of the coding region of the TFAP2A gene revealed missense mutations in four branchio-oculo-facial syndrome patients; one patient was observed to have a previously described mutation (p.Arg251Gly), while three patients from two families were found to have novel mutations: p.Arg213Ser and p.Val210Asp.

Cow (Bovine) Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A) interaction partners

Mouse (Murine) Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A) interaction partners

  1. TFAP2A is a conserved component of the core network that regulates EMT, acting as a repressor of many genes, including ZEB2.

  2. The AP-2beta (show TFAP2B Proteins) transcription factor is an important effector of PITX2 (show PITX2 Proteins) function during corneal development, required for differentiation of corneal endothelium and establishment of angiogenic privilege.

  3. the regulation of synaptic-vesicle (SV) recycling via early endosomes by the interdependent regulation of AP-2-mediated endocytosis and AP-1 (show JUN Proteins)/sigma1B (show AP1S2 Proteins)-mediated SV reformation, is reported.

  4. By gain-of function and loss-of-function approaches, ap2a and 2b were identified to be the major downstream targets of Ptf1a (show PTF1A Proteins) to specify the amacrine cell fate.

  5. Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 (show FGF8 Proteins) gene dosage

  6. results suggested that RNF20 (show RNF20 Proteins) may play roles in adipocyte differentiation by stimulating ubiquitin-proteasome-dependent degradation of AP-2alpha.

  7. These findings indicate that Suv39h1 (show SUV39H1 Proteins) enhances AP-2alpha-mediated transcriptional repression of C/EBPalpha (show CEBPA Proteins) in an epigenetic manner and further inhibits adipocyte differentiation.

  8. N-terminal peptide sequencing indicates use of a downstream start codon in the human ortholog of AP-2.

  9. AP-2alpha defines epididymis-specific androgen receptor (show AR Proteins) recruitment. It is constitutively bound to chromatin and guides AR to specific genomic loci upon hormone exposure.

  10. our data indicate that miR-17-92 modulates expression of critical T-box transcriptional regulators during midface development and is itself a target of Bmp-signaling and the craniofacial pioneer factor AP-2alpha

TFAP2A Protein Profile

Protein Summary

The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TFAP2A

  • transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (tfap2a)
  • transcription factor AP-2 alpha (tfap2a-a)
  • transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A)
  • transcription factor AP-2 (AP-2)
  • transcription factor AP-2 alpha (TFAP2A)
  • transcription factor AP-2 (Ap-2)
  • Transcription factor AP-2 alpha (ap2a)
  • fatty acid binding protein 4, adipocyte (Fabp4)
  • transcription factor AP-2 alpha (Tfap2a)
  • transcription factor AP-2 alpha (tfap2a)
  • transcription factor AP-2, alpha (Tfap2a)
  • Albp protein
  • Ap-2 protein
  • AP-2alpha protein
  • Ap2 protein
  • ap2a protein
  • AP2alpha protein
  • Ap2tf protein
  • BOFS protein
  • cb93 protein
  • fb83f04 protein
  • fc31a07 protein
  • Tcfap2a protein
  • TFAP2 protein
  • TFAP2A protein
  • tfap2a-a protein
  • tfap2alpha protein
  • wu:fb83f04 protein
  • wu:fc31a07 protein
  • XAP-2 protein
  • xap2 protein

Protein level used designations for TFAP2A

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) , transcription factor AP-2 alpha , AP-2 transcription factor , transcription factor AP-2-alpha , transcription factor AP-2 , Transcription factor AP-2 alpha , A-FABP , AFABP , adipocyte lipid-binding protein , adipocyte-type fatty acid-binding protein , fatty acid-binding protein 4 , fatty acid-binding protein, adipocyte , AP2-alpha , activating enhancer-binding protein 2 alpha , activating enhancer-binding protein 2-alpha , activator protein 2 , ap2 , ap2a , lockjaw , low , mob , mont blanc , AP-2 alpha , Ap-2 (a)

395064 Xenopus (Silurana) tropicalis
394344 Xenopus laevis
395982 Gallus gallus
462426 Pan troglodytes
488213 Canis lupus familiaris
503683 Xenopus laevis
663046 Tribolium castaneum
700663 Macaca mulatta
100302602 Bombyx mori
100306784 Salmo salar
100600252 Nomascus leucogenys
79451 Rattus norvegicus
306862 Rattus norvegicus
140618 Danio rerio
7020 Homo sapiens
505849 Bos taurus
443109 Ovis aries
21418 Mus musculus
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