Browse our anti-Topoisomerase I (TOP1) Antibodies

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anti-Topoisomerase (DNA) I Antibodies (TOP1)
On are 93 Topoisomerase (DNA) I (TOP1) Antibodies from 20 different suppliers available. Additionally we are shipping Topoisomerase I Kits (22) and Topoisomerase I Proteins (13) and many more products for this protein. A total of 132 Topoisomerase I products are currently listed.
Ab2-086, AI467334, CG6146, D130064I21Rik, Dmel\\CG6146, DNA topoisomerase 1 beta, DNA topoisomerase I alpha, dTopoI, l(1)G0134, l(1)G0201, l(1)G0229, l(1)G0278, l(1)top1, MGO1, MGOUN 1, MTE17.1, MTE17_1, Top-1, top1, TOP1BETA, topi, topo I, topoI, TOPOISOMERASE 1

Most Popular Reactivities for anti-Topoisomerase I (TOP1) Antibodies

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Top referenced anti-Topoisomerase I Antibodies

  1. Human Monoclonal Topoisomerase I Primary Antibody for WB - ABIN1882055 : DArpa, Machlin, Ratrie, Rothfield, Cleveland, Earnshaw: cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment. in Proceedings of the National Academy of Sciences of the United States of America 1988 (PubMed)
    Show all 4 references for 1882055

  2. Human Monoclonal Topoisomerase I Primary Antibody for WB - ABIN967555 : Sugimoto, Tsukahara, Oh-hara, Isoe, Tsuruo: Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody. in Cancer research 1990 (PubMed)
    Show all 2 references for 967555

  3. Human Polyclonal Topoisomerase I Primary Antibody for IP, WB - ABIN440776 : Kim, Rahmanto, Tan, Norris, Haber, Marshall, Cheung: TRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells. in Apoptosis : an international journal on programmed cell death 2013 (PubMed)
    Show all 2 references for 440776

  4. Human Polyclonal Topoisomerase I Primary Antibody for IF, WB - ABIN657818 : Kjeldsen, Tordrup, Hübner, Knudsen, Andersen: Topoisomerase I deficiency results in chromosomal alterations in cervical cancer cells. in Anticancer research 2010 (PubMed)
    Show all 2 references for 657818

  5. Human Monoclonal Topoisomerase I Primary Antibody for IHC (p), ELISA - ABIN563222 : Kobayashi, Aida, Nagaoka, Begum, Kitawaki, Nakata, Stanlie, Doi, Kato, Okazaki, Shinkura, Muramatsu, Kinoshita, Honjo: AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

More Antibodies against Topoisomerase I Interaction Partners

Fruit Fly (Drosophila melanogaster) Topoisomerase (DNA) I (TOP1) interaction partners

  1. B52 delivers Topo I to RNA polymerase II-active chromatin loci and DNA topology and mRNA release can be coordinated to control gene expression.

  2. In a model of human epilepsy, topo I shows a novel function in construction and/or maintenance of circuits required for seizure propagation in vivo.

Arabidopsis thaliana Topoisomerase (DNA) I (TOP1) interaction partners

  1. In the floral meristem, the binding of AG to WUS is reduced in top1a-2, which results in reduced H3K27me3 levels at WUS and prolonged WUS expression, and consequently loss of floral determinacy.

  2. Further studies with Arabidopsis top1alpha mutants showed that TOP1alpha silences endogenous RdDM loci by facilitating the production of Pol V-dependent long non-coding RNAs, AGONAUTE4 recruitment and H3K9me2 deposition at TEs (show TES Antibodies) and repeats

  3. MGO1 encodes a putative Arabidopsis type IB topoisomerase that functions together with WUS in stem cell regulation. [MGO1]

Caenorhabditis elegans (C. elegans) Topoisomerase (DNA) I (TOP1) interaction partners

  1. While TOP-1alpha isoform has tissue specificity, the TOP-1beta isoform is expressed in most tissues and cells. RNAi targeted to both TOP-1 isoforms demonstrated that TOP-1 is required for chromosomal segregation, germline proliferation and gonadal migration.

Human Topoisomerase (DNA) I (TOP1) interaction partners

  1. HMGA2 potentiates the clinically important topoisomerase I inhibitor irinotecan/SN-38 in trapping the enzyme in covalent DNA-complexes, thereby attenuating transcription.

  2. IMMP2L (show IMMP2L Antibodies) transcription requires Topoisomerase I in human primary astrocytes

  3. This work identifies ADP-ribose polymers as key determinant for regulating Top1 subnuclear dynamics.

  4. High prevalence of anti-topoisomerase I antibody positivity was found among Thai systemic sclerosis patients and this was associated with a high frequency of hand deformity, ACA negativity, a short duration of pulmonary fibrosis in diffuse cutaneous and a lower frequency of Raynaud's phenomenon in limited cutaneous subsets.

  5. These findings reveal BAZ1B (show BAZ1B Antibodies) as a key facilitator of topoisomerase I function during DNA replication that affects the response of cancer cells to topoisomerase I inhibitors.

  6. Results identified TOP1 gene copy gain, a loss of chromosome 20, and new yet unreported TOP1 mutations (R364K and G717R) in close proximity to the SN-38 binding site conferring colon cancer cells resistance to the drug.

  7. the highest expression of GGH (show GGH Antibodies) and EGFR (show EGFR Antibodies) was noted in the left-sided colon; the highest expression of DHFR (show DHFR Antibodies), FPGS (show FPGS Antibodies), TOP1 and ERCC1 (show ERCC1 Antibodies) was noted in the rectosigmoid, whereas TYMP (show TYMP Antibodies) expression was approximately equivalent in the right-sided colon and rectum

  8. We found that the resistant cell lines showed 7-100 fold increased resistance to SN-38 but remained sensitive to docetaxel and the non-camptothecin Top1 inhibitor LMP400

  9. Data show that the single-molecule supercoil relaxation assay is a sensitive method to elucidate the detailed mechanisms of type IB topoisomerase (Top1) inhibitors and is relevant for the cellular efficacy of Top1 inhibitors.

  10. TOP1 bound at promoters was discovered to become fully active only after pause-release. This transition coupled the phosphorylation of the carboxyl-terminal-domain (CTD) of RNA polymerase II (RNAPII) with stimulation of TOP1 above its basal rate, enhancing its processivity.

Mouse (Murine) Topoisomerase (DNA) I (TOP1) interaction partners

  1. treatment of topotecan, a brain-penetrating topoisomerase 1 inhibitor, to HD transgenic mouse considerably improved its motor behavioural abnormalities. Finally, we show that topotecan treatment to HD mouse not only inhibits the expression of transgenic mutant huntingtin (show HTT Antibodies), but also at the same time induces the expression of Ube3a (show ube3a Antibodies)

  2. It has been shown that the livers of Sprtn deficient mice accumulate DNA-protein crosslinks containing Topoisomerase 1 covalently linked to DNA.

  3. this study identified topoisomerase 1 as a cardinal (show CARD8 Antibodies) Aire (show AIRE Antibodies) partner that colocalized on super-enhancers and was required for the interaction of Aire (show AIRE Antibodies) with all of its other associates

  4. Data indicate that mitochondrial topoisomerase I (TOP1mt (show TOP1MT Antibodies)) knockout (KO) mice showed a marked reduction in regeneration and hepatocyte proliferation.

  5. Topoisomerase I deficiency in B cells is associated with RNA polymerase II accumulation, recruitment of activation-induced deaminase (show AICDA Antibodies) (AID) to immunoglobulin variable genes and the mechanism for increased diversity of these genes.

  6. Findings suggest that topoisomerase 1 (TOP1) controls the levels of multiple synaptic proteins and is required for normal excitatory and inhibitory synaptic transmission.

  7. Top1mt (show TOP1MT Antibodies) accumulates in the regulatory region of mitochondrial DNA.

  8. our data implicate Top1mt (show TOP1MT Antibodies) for mitochondrial integrity and energy metabolism.

  9. model in which small molecule inhibitors convert PARP1 (show PARP1 Antibodies) into a protein that potentiates the effects of topoisomerase I poisons by binding to damaged DNA and preventing its normal repair.

  10. AID-induced Top1 reduction alters S region DNA structure probably to non-B form, on which Top1 can introduce nicks but cannot religate, resulting in S region cleavage.

Topoisomerase I (TOP1) Antigen Profile

Antigen Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.

Alternative names and synonyms associated with Topoisomerase I (TOP1)

  • Topoisomerase 1 (Top1) antibody
  • DNA topoisomerase I (top1) antibody
  • DNA topoisomerase I (topA) antibody
  • DNA topoisomerase I (ZMO1193) antibody
  • DNA topoisomerase I (Mrad2831_6322) antibody
  • DNA topoisomerase I (Lferr_0016) antibody
  • DNA topoisomerase I (PC1_2015) antibody
  • DNA topoisomerase I (Za10_0136) antibody
  • DNA topoisomerase I (Gbro_0575) antibody
  • DNA topoisomerase I (Dd586_2108) antibody
  • DNA topoisomerase I (Kvar_3044) antibody
  • DNA topoisomerase I (Alvin_2069) antibody
  • DNA topoisomerase I (Dacet_0849) antibody
  • DNA topoisomerase I (Mrub_1615) antibody
  • DNA topoisomerase I (Arnit_2962) antibody
  • DNA topoisomerase I (Ndas_4953) antibody
  • DNA topoisomerase I (Trad_2377) antibody
  • DNA topoisomerase I (Acear_1653) antibody
  • DNA topoisomerase I (Mahau_0844) antibody
  • DNA topoisomerase I (Mesop_4109) antibody
  • DNA topoisomerase I (Thein_1586) antibody
  • DNA topoisomerase I (Theth_0241) antibody
  • DNA topoisomerase 1 (TOP1ALPHA) antibody
  • Protein TOP-1 (top-1) antibody
  • topoisomerase (DNA) I (TOP1) antibody
  • topoisomerase (DNA) I (Top1) antibody
  • topoisomerase (DNA) I, gene 1 (top1.1) antibody
  • Ab2-086 antibody
  • AI467334 antibody
  • CG6146 antibody
  • D130064I21Rik antibody
  • Dmel\\CG6146 antibody
  • DNA topoisomerase 1 beta antibody
  • DNA topoisomerase I alpha antibody
  • dTopoI antibody
  • l(1)G0134 antibody
  • l(1)G0201 antibody
  • l(1)G0229 antibody
  • l(1)G0278 antibody
  • l(1)top1 antibody
  • MGO1 antibody
  • MGOUN 1 antibody
  • MTE17.1 antibody
  • MTE17_1 antibody
  • Top-1 antibody
  • top1 antibody
  • TOP1BETA antibody
  • topi antibody
  • topo I antibody
  • topoI antibody
  • TOPOISOMERASE 1 antibody

Protein level used designations for TOP1

CG6146-PA , CG6146-PB , CG6146-PC , CG6146-PD , Top1-PA , Top1-PB , Top1-PC , Top1-PD , topoisomerase 1 , topoisomerase I , topoisomerase1 , type I topoisomerase , DNA topoisomerase I , DNA topoisomerase 1 , type I DNA topoisomerase

32458 Drosophila melanogaster
2540032 Schizosaccharomyces pombe 972h-
2649678 Corynebacterium diphtheriae NCTC 13129
3189286 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
6141892 Methylobacterium radiotolerans JCM 2831
6875965 Acidithiobacillus ferrooxidans ATCC 53993
8132959 Pectobacterium carotovorum subsp. carotovorum PC1
8471215 Zymomonas mobilis subsp. mobilis NCIMB 11163
8549909 Gordonia bronchialis DSM 43247
8661047 Dickeya dadantii Ech586
8783203 Klebsiella variicola At-22
8787439 Allochromatium vinosum DSM 180
8875197 Denitrovibrio acetiphilus DSM 12809
8879720 Meiothermus ruber DSM 1279
9173158 Arcobacter nitrofigilis DSM 7299
9248841 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9281380 Truepera radiovictrix DSM 17093
9513710 Acetohalobium arabaticum DSM 5501
10607584 Mahella australiensis 50-1 BON
10827957 Mesorhizobium opportunistum WSM2075
10841850 Thermodesulfatator indicus DSM 15286
10884985 Thermotoga thermarum DSM 5069
835623 Arabidopsis thaliana
266847 Caenorhabditis elegans
7150 Homo sapiens
21969 Mus musculus
64550 Rattus norvegicus
399263 Xenopus laevis
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