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Human CD51 Protein expressed in Wheat germ - ABIN2866314
Ahn, Mohamedali, Anand, Cheruku, Birch, Sowmya, Cantor, Ranganathan, Inglis, Frank, Agrez, Nice, Baker: Characterization of the interaction between heterodimeric ?v?6 integrin and urokinase plasminogen activator receptor (uPAR) using functional proteomics. in Journal of proteome research 2014
Tat (show TAT Proteins) PTD (show ETS2 Proteins)-Endostatin (show COL18A1 Proteins)-RGD showed high penetration ability through ocular barriers, bound specifically to integrin alpha5beta3 and effectively inhibited the abnormal angiogenesis. Tat (show TAT Proteins) PTD (show ETS2 Proteins)-Endostatin (show COL18A1 Proteins)-RGD represents a potent novel drug applied via eye drops for fundus oculi neovascularization diseases.
The synergy of circulating factor suPAR and APOL1 (show APOL1 Proteins) G1 or G2 on alphavbeta3 integrin activation is a mechanism for CKD.
Suggest that alphavbeta3 integrin plays an important role in coordinating hepatocyte division during liver regeneration after partial hepatectomy via crosstalk with fibrin ECM (show MMRN1 Proteins).
Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta (show TGFB1 Proteins).
This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity.
These data support the hypothesis that IL-1beta (show IL1B Proteins) was initially induced by hyperoxia; alphavbeta6 subsequently interacted with and activated TGF-beta1 (show TGFB1 Proteins).
Gdf-5 (show GDF5 Proteins) induced the expression of the alpha5 sub-unit, while Bmp-7 (show BMP7 Proteins) induced the expression of the alphaV sub-unit.
These results suggest that phloretin was an inhibitor of actin podosomes and sealing zone, disrupting alpha5beta3 integrin-c-Src-Pyk2/Syk signaling pathway for the regulation of actin cytoskeletal organization in osteoclasts.
TN-C (show TNC Proteins) may enhance inflammatory responses by accelerating macrophage migration and synthesis of proinflammatory/profibrotic cytokines via integrin alphaVbeta3/FAK (show PTK2 Proteins)-Src (show SRC Proteins)/NF-kappaB (show NFKB1 Proteins), resulting in increased fibrosis.
Lung histology revealed aberrant elastin (show ELN Proteins) production and impaired lung septation in oxygen-exposed lungs, while tropoelastin (show ELN Proteins), integrin alphav, fibulin-1 (show FBLN1 Proteins), fibulin-2 (show FBLN2 Proteins) and fibulin-4 (show FBLN4 Proteins) gene expression were elevated.
The results indicate that shear stress is an important mediator in endothelial progenitor cells expression of CD59 regulated by the extacellular matrix-integrin alphaVbeta3-F-actin pathway, which is a key factor in preventing membrane attack complex-mediated cell autolysis.
The mechanism of resistance of tongue squamous carcinoma cells Cal27 with de novo integrin alphavbeta3 expression to anticancer drugs was studied. In Cal27 cells integrin alphav heterodimers signal through pSrc(Y418) while this is not the case in integrin alphavbeta3-expressing cells.
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R (show IGF1R Proteins).
data demonstrate that M. tuberculosis stimulation upregulates integrin alphaVbeta3 expression on monocytes, which upregulates secretion of MMP-1 (show MMP1 Proteins) and -10 on adhesion to the extracellular matrix; this leads to increased monocyte recruitment and collagenase activity, which will drive inflammatory tissue damage
overexpression of syndecan-1 confers to B-LCs an increased capacity to migrate in response to Tat, owing to a switch from a CXCR4/G-protein/Rac to a syndecan-1/alphavbeta3/pp60src/pp125FAK signal transduction pathway that depends on the formation of a complex in which syndecan-1 interacts with Tat via its HS-chains, with alphavbeta3 via its core protein ectodomain and with pp60src via its intracellular tail
sPLA2-IIA (show PLA2G2A Proteins) activates Integrin alphaVbeta3 and Integrin alpha4beta1 in an allosteric manner. (Review)
These results indicate that CD51 is a novel functional marker for colorectal CSCs which may provide an therapeutic target for the efficient elimination of colorectal CSCs.
Data show that dendritic cells (DCs) induced Th17 cell differentiation through miR (show MLXIP Proteins)-363/Integrin alphav/TGF-beta (show TGFB1 Proteins) pathway in patients with rheumatoid arthritis (RA).
integrin alphaVbeta6 binds pro-TGF-beta1 (show TGFB1 Proteins) in an orientation biologically relevant for force-dependent release of TGF-beta (show TGFB1 Proteins) from latency
The observed effects of shear stress on integrin alpha(v)beta(3) and p38 MAPK (show MAPK14 Proteins) activation, as well as on FGF-2 (show FGF2 Proteins) release could be mimicked by application of pancreatic elastase to static endothelial cells.
Inhibition of integrin alphavbeta3 prevents urokinase plasminogen (show PLG Proteins) activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia.
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
specific substitutions show that the stable binding between foot-and-mouth disease virus VP1 and integrin alphavbeta6 is dependent on a helical structure and, specifically, two leucine residues at positions +1 and RGD +4 from the RGD motif.
These results demonstrate the critical role of the RhoA (show RHOA Proteins)/alphavbeta5 integrin pathway in mediating Pseudomonas aeruginosa-induced lung vascular permeability.
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8\; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands\; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants.
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
, alphav integrin
, integrin alpha V
, integrin alpha-V
, vitronectin receptor alpha polypeptide (VNRA)
, vitronectin receptor subunit alpha
, antigen identified by monoclonal antibody L230
, integrin alphaVbeta3
, Dnmt3l-ps1 pseudogene
, alphaV integrin
, integrin alpha v
, vitronectin receptor alpha subunit
, integrin alpha V subunit