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Results indicate that pre- and peri (show POSTN Proteins)-implantation development does not require connexin43 (Cx43 (show GJA1 Proteins)) and connexin45 (Cx45).
The ablation of Cx45 reduced neuronal loss by approximately 50% under ischemic insult.
This study demonstrated using Cx45-eGFP transgenic mice that Cx45-eGFP cells are distributed along the rostrocaudal extent of the spinal cord with expression mainly restricted to the grey matter of dorsal laminae I-III
Prostaglandin E stimulates Connexin isoforms via GSK-3beta/beta-catenin (show CTNNB1 Proteins) via EP2-receptor-dependent cAMP/PKA and PI3K/Akt (show AKT1 Proteins) in mouse embryonic stem cells.
Suggest critical role for Cx45 in the regulation of endothelial-induced mesenchymal cell differentiation towards a mural cell phenotype.
Cx45 is required for optimal impulse propagation in the atrioventricular node; cardiomyocyte-directed deficiencies of Cx45 in mice lead to embryonic lethality attributable to morphological and functional cardiovascular defects.
Cx45 is physiologically expressed in vascular smooth muscle
Residual Cx45 and its relationship to Cx43 (show GJA1 Proteins) in murine ventricular myocardium.
The cx45 strongly modulate the firing pattern of individual RGCs, ensuring strongly correlated firing between nearby RGCs and normal patterning of retinogeniculate projections.
Data suggest that Cx45 is expressed on OFF bipolar cell dendrites, presumably forming gap junctions with cells of the same type, and on OFF bipolar cell axon terminals, presumably forming heterologous gap junctions with other retinal neurons.
Observations involving both N- and C-domains of CaM to interact with the Cx45 peptide differ from the embraced interaction with Cx50 (show GJA8 Proteins) from another connexin family
Human deltoid muscle biopsies of 5 Chilean dysferlinopathy patients exhibited the presence of muscular connexins (Cx40.1, Cx43 (show GJA1 Proteins) and Cx45).
Connexin45 has much more rapid gating kinetics than connexin43 (show GJA1 Proteins)
Results found that the expression of Cx26 (show GJB2 Proteins) and Cx45 had no prognostic value but Cx43 (show GJA1 Proteins) was upregulated in tumour epithelia and membrane Cx43 (show GJA1 Proteins) expression was associated with short overall survival time.
Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 (show GJA1 Proteins) rather than on Cx45.
Our data suggest that GJA7 alterations have no or low genetic relevance in nonsyndromic hearing loss in populatins from Turkey, South Africa, United Kingdom, United States, and China.
DNA hypermethylation of the promoter region of GJC1, encoding connexin45, is an important mechanism in silencing gene expression in colorectal cancer.
Study shows that fusion of a V5/6-His tag (hexa (show HEXA Proteins) moiety M r = 0.93 kDa) to the CT segment of Cx40 (show GJA5 Proteins), Cx43 (show GJA1 Proteins) and Cx45 does not prevent the cells from forming channels.
connexin genes Gjd2 (show GJD2 Proteins) coding for mCx36, Gjc1 coding for mCx45 and Gja10 coding for mCx57 in the mouse, a subset of 4 connexin genes, including the unique GJA9 (Cx59) and GJA10 (Cx62 (show GJa10 Proteins)), could be detected at least as transcript isoforms in the human retina.
Results show that Cx40 (show GJA5 Proteins), Cx37 (show GJA4 Proteins), Cx43 (show GJA1 Proteins) and Cx45 were expressed within the glomeruli.
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described.
gap junction protein, gamma 1, 45kDa
, connexin 45
, gap junction protein, alpha 7, 45kDa
, gap junction protein, delta 3, 31.9kDa
, gap junction membrane channel protein alpha 7
, gap junction gamma-1 protein-like
, Gap junction alpha-7 protein
, gap junction gamma-1 protein
, gap junction delta-3 protein
, gap junction membrane channel protein chi 1
, gap junction alpha-7 protein
, gap junction channel protein connexin 45
, gap junction protein, alpha 7, 45kDa (connexin 45)