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This is the first report of an NLGN2 nonsense variant in humans, adding to the accumulating evidence that links synaptic proteins with a spectrum of neurodevelopmental phenotypes.
MDGAs regulate the formation of neuroligin-neurexin (show NRXN1 Proteins) trans-synaptic bridges by sterically blocking access of neurexins to neuroligins.
Neuroligin-2 was down-regulated in aganglionic colonic segments from Hirschsprung's disease patients.
Transcellular neuroligin-2 interactions enhance insulin (show INS Proteins) secretion and are integral to pancreatic beta cell function
The alternatively spliced segment 4 (AS4) of NRX genes (Nrxn) is a critical element in selective trans-synaptic interactions. This study evaluated the synaptogenic receptor activity of NL1/2/3 isoforms in a neuron-fibroblast co-culture system, in which the Nrxn AS4 segments are manipulated using SLM2, a selective and dominant regulator of AS4 splicing.
Neuroligin 2 deletion predominantly affects inhibitory synapses onto projection neurons in basal amygdala, resulting in decreased inhibitory drive onto these neurons and leading to their excessive activation under anxiogenic conditions.
Results indicate that Nlgn2 is required for continuous maintenance of inhibitory synapses in the adult medial prefrontal cortex
Results highlight the importance of neuroligin-2 in mediating early-life stress effects on social behavior and social cognition.
Neuroligin-2 was essential for maintaining normal climbing-fiber synapse numbers in purkinje cell circuits.
Endogenous NL2 (show MMEL1 Proteins) undergoes proline-directed phosphorylation at its unique S714-P consensus site, leading to the recruitment of Pin1 (show PIN1 Proteins). This signaling cascade negatively regulates NL2 (show MMEL1 Proteins)'s ability to interact with gephyrin (show GPHN Proteins) at GABAergic post-synaptic sites.
analysis of neuroligin-2 trafficking and proteomics
Cholinergic cells express neuroligin 2 in a subset of their input synapses.
NL2 (show MMEL1 Proteins) also regulates KCC2 (show SLC12A5 Proteins) to modulate GABA functional switch.
Two subsynaptic domains, one containing IgSF9b for synaptic adhesion and the other containing gephyrin (show GPHN Proteins) and GABAA (show GABRg1 Proteins) receptors for synaptic transmission, are interconnected through S-SCAM (show MAGI2 Proteins) and neuroligin 2.
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.
, carboxylesterase clade L, member 2
, ortholog of human and rat neuroligin 2 NLGN2