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Bmi1 expression is related to a refractory clinical course of IBD and upregulated in refractory IBD and CAC (show CA2 Proteins).
High BMI1 expression is associated with ovarian cancer.
Bmi-1 positively regulates stem cell-like properties via upregulating miR (show MLXIP Proteins)-21, and miR (show MLXIP Proteins)-34a negatively regulates stem cell-like characteristics by negative feedback regulation of Bmi-1 in gastric cancer. Bmi-1 upregulates miR (show MLXIP Proteins)-21 and miR (show MLXIP Proteins)-34a by activating AKT (show AKT1 Proteins)-NF-kB pathway.
Data show that C/EBPalpha (show CEBPA Proteins) is a tumor suppressor in lung cancer and that BMI1 is required for the oncogenic process downstream of C/EBPalpha (show CEBPA Proteins) loss.
Study not only uncovers a novel functional PTMs of Bmi-1 but also reveals a unique oncogenic role of O-GlcNAcylation in prostate cancer.
We found that BMI1 showed increased expression in hypoxic-cultured hUCB-MSCs, and the further knock-down of BMI1 in hypoxic cells induced decreased proliferative and immunomodulatory abilities in hUCB-MSCs, along with COX-2/PGE2 down-regulation. More importantly, we identified BMI1 as a direct repressor of MAP kinase phosphatase-1 (MKP-1 (show DUSP1 Proteins))/DUSP1 (show DUSP1 Proteins), which suppresses p38 MAP kinase (show MAPK14 Proteins) activity.
Collectively, the data establish a hitherto unknown liaison among MDR1, BMI1 and TIP60 (show KAT5 Proteins) and provide mechanistic insights into cisplatin-induced MDR1 expression resulting in acquired cross-resistance against paclitaxel, doxorubicin and likely other anticancer drugs.
Thus, VEGFA (show VEGFA Proteins) stimulates ovarian cancer stem-like cells through Src (show SRC Proteins)-DNMT3A (show DNMT3A Proteins)-driven miR (show MLXIP Proteins)-128-2 methylation and Bmi1 upregulation.
Loss of BMI1 enhanced ribonuclease activity of polynucleotide phosphorylase and reduced mtRNA stability
These findings uncover a previously unrecognized role for MUC1 (show MUC1 Proteins)-C in driving BMI1 expression and in directly interacting with this stem cell factor (show KITLG Proteins), linking MUC1 (show MUC1 Proteins)-C with function of the PRC1 (show PRC1 Proteins) in epigenetic gene silencing.
BMI1 and MEL18 (show PCGF2 Proteins) contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b. REG3B negatively regulates cytokine-induced activation of STAT3 (show STAT3 Proteins) in colon epithelial cells.
KLF4 (show KLF4 Proteins) modulates development of BMI1-expressing intestinal stem cell-derived lineage following gamma-radiation-induced gut (show GUSB Proteins) injury in mice.
The retinal phenotype of Bmi1(-/-) mice was characterized by loss of heterochromatin, activation of tandem repeats, oxidative stress and Rip3-associated necroptosis.
Inducible fate mapping demonstrates that BMI1 is expressed in vivo by multipotent Olfactory epithelium progenitors. expression of BMI1 and other Polycomb (show CBX2 Proteins) proteins not previously identified in olfactory basal cells are essential for self-renewal.
We conclude that silencing of Bmi1 by miR (show MLXIP Proteins)-27b relieves repression of the presynaptic transcriptome and supports neurotransmission in cortical networks.
a full complement of Bmi-1 is required for the intestinal proliferative effects of GLP-2 in both the physiological and pathological setting
Our work revealed that MOZ and BMI1 regulate HSCs in a synergistic manner by acting on distinct processes required to maintain HSCs.
Bmi-1 played a critical role in the protection from acute tubular necrosis by maintaining mobilization of renal stem cells and would be a novel therapeutic target for preventing the progression of ATN
Bmi1 acts immediately downstream of CCAAT enhancer binding protein-alpha (show CEBPA Proteins) to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.
Pig Bmi1 cDNA is 3,193 bp in length and consists of a 981 bp open reading frame, a 256 bp 5 (show HSPD1 Proteins)' untranslated region (UTR), and a 1,956 bp 3 (show BST1 Proteins)' UTR. The transcript contains no signal peptides and there are no transmembrane regions in the pig Bmi1 coded protein.
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).
B lymphoma Mo-MLV insertion region 1 homolog
, murine leukemia viral (bmi-1) oncogene homolog
, polycomb complex protein BMI-1
, polycomb group RING finger protein 4
, polycomb group protein Bmi1
, ring finger protein 51
, BMI1 polycomb ring finger oncogene
, B lymphoma Mo-MLV insertion region 1
, polycomb group ring finger 4
, polycomb complex protein BMI-1-A
, polycomb group RING finger protein 4-A
, B lymphoma Mo-MLV insertion region
, Polycomb group RING finger protein 4-B
, polycomb complex protein BMI-1-B
, polycomb group RING finger protein 4-B
, oncoprotein BMI-1