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High Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 (show FOSB ELISA Kits) is involved in colorectal cancer metastasis.
Data indicate that microRNA miR (show MLXIP ELISA Kits)-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) through inhibition of E2F2 transcription factor (E2F2 (show E2F2 ELISA Kits)), cyclin (show PCNA ELISA Kits)-dependent kinases CDK3 and CDK6 (show CDK6 ELISA Kits).
Mir (show MLXIP ELISA Kits)-873 inhibits ESR1 (show ESR1 ELISA Kits) activity and cell growth via targeting CDK3.
CDK3 is associated with the progression of NPC (show NPC1 ELISA Kits), and may be a potential biomarker for prediction of the prognosis of patients with NPC (show NPC1 ELISA Kits).
The Walleye dermal sarcoma virus cyclin (show PCNA ELISA Kits) functions as a structural ortholog of cyclin C (show CCNC ELISA Kits) in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 (show CDK8 ELISA Kits) and Cdk3.
A non-cdk8 (show CDK8 ELISA Kits)-associated cellular pool of cyclin C (show CCNC ELISA Kits) combines with cdk3 to stimulate pRb (show RB1 ELISA Kits) phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
Expression level of cdk3 is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 phosphorylates activating transcription factor 1 (ATF1 (show AFT1 ELISA Kits))and enhances the transactivation and transcriptional activities of ATF1 (show AFT1 ELISA Kits).
Results indicated that CDKL3 (show CDKL3 ELISA Kits) may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
CDKL3 (show CDKL3 ELISA Kits) is involved in neuronal morphogenesis during development.
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
cyclin-dependent kinase 3
, cell division protein kinase 3