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These results provided evidence supporting the oncogenic potential of NFAT3 (show NFATC4 Proteins) and suggested that CDK3-mediated phosphorylation of NFAT3 (show NFATC4 Proteins) has an important role in skin tumorigenesis.
The analysis of tumor and matched normal lung tissues indicates that miR (show MLXIP Proteins)-150 downregulation in lung tumors correlates with higher CDK3 levels. In addition, miR (show MLXIP Proteins)-150 transfection experiments with cancer-derived cell lines reveal that miR (show MLXIP Proteins)-150-mediated CDK3 suppression directly induces growth inhibition.
High Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 (show FOSB Proteins) is involved in colorectal cancer metastasis.
Data indicate that microRNA miR (show MLXIP Proteins)-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC (show FAM126A Proteins)) through inhibition of E2F2 transcription factor (E2F2 (show E2F2 Proteins)), cyclin (show PCNA Proteins)-dependent kinases CDK3 and CDK6 (show CDK6 Proteins).
Mir (show MLXIP Proteins)-873 inhibits ESR1 (show ESR1 Proteins) activity and cell growth via targeting CDK3.
CDK3 is associated with the progression of NPC (show NPC1 Proteins), and may be a potential biomarker for prediction of the prognosis of patients with NPC (show NPC1 Proteins).
The Walleye dermal sarcoma virus cyclin (show PCNA Proteins) functions as a structural ortholog of cyclin C (show CCNC Proteins) in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 (show CDK8 Proteins) and Cdk3.
A non-cdk8 (show CDK8 Proteins)-associated cellular pool of cyclin C (show CCNC Proteins) combines with cdk3 to stimulate pRb (show RB1 Proteins) phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
Expression level of cdk3 is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 phosphorylates activating transcription factor 1 (ATF1 (show AFT1 Proteins))and enhances the transactivation and transcriptional activities of ATF1 (show AFT1 Proteins).
Results indicated that CDKL3 (show CDKL3 Proteins) may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
CDKL3 (show CDKL3 Proteins) is involved in neuronal morphogenesis during development.
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
cyclin-dependent kinase 3
, cell division protein kinase 3