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Browse our CDK9 Proteins (CDK9)

Full name:
Cyclin-Dependent Kinase 9 Proteins (CDK9)
On www.antibodies-online.com are 9 Cyclin-Dependent Kinase 9 (CDK9) Proteins from 4 different suppliers available. Additionally we are shipping CDK9 Antibodies (136) and CDK9 Kits (28) and many more products for this protein. A total of 179 CDK9 products are currently listed.
Synonyms:
C-2k, CDC2L4, cdk9, CG5179, CTK1, Dmel\\CG5179, P-TEF, P-TEFb, PITALRE, PTefb, TAK, wu:fb22e09, wu:fc06c02
list all proteins Gene Name GeneID UniProt
CDK9 1025 P50750
CDK9 362110 Q641Z4
CDK9 107951 Q99J95

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CDK9 Proteins (CDK9) by Origin

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More Proteins for CDK9 Interaction Partners

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 9 (CDK9) interaction partners

  1. actin (show ACTB Proteins) participates in transcription elongation by recruiting Cdk9,a catalytic subunit of P-TEFb, for phosphorylation of the Pol II C-terminal domain, and the actin (show ACTB Proteins)-Cdk9 interaction promotes chromatin remodeling

  2. Genetic transcription and RNA processing of PTefb kinase is coordinated on heat shock genes.

  3. Cdk9 is required for heat shock gene expression, histone methylation and elongation factor (show TSFM Proteins) recruitment.

Human Cyclin-Dependent Kinase 9 (CDK9) interaction partners

  1. Our findings suggest a potential role of CDK9 in the radiation response of head and neck squamous cell carcinoma cells

  2. Systematic Determination of Human CDK9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DDX5 (show DDX5 Proteins) and DDX17 (show DDX17 Proteins) RNA Helicases

  3. In vitro phosphorylation of pUL69 by CDK9 or pUL97 did not occur in a single site-specific manner, but at multiple sites.

  4. the introduction of HIV-1 Tat (show TAT Proteins) and Mg12+ ion resulted in the active site architectural characteristics of phosphorylated CDK9/cyclin T1 (show CCNT1 Proteins) complex

  5. miR (show MLXIP Proteins)-191 represses proliferation in primary human fibroblasts via targeting multiple proto-oncogenes, including CDK9, NOTCH2 (show NOTCH2 Proteins), and RPS6KA3 (show RPS6KA3 Proteins).

  6. Essential for MYC (show MYC Proteins) expreession increase upon CDK9 inhibition is that the bromodomain protein BRD4 (show BRD4 Proteins) captures P-TEFb (show CCNT1 Proteins) from 7SK snRNP (show LSM2 Proteins) to deliver to target genes and also enhances CDK9's activity and resistance to inhibition.

  7. Suggest up-regulation of CDK9 kinase activity and Mcl-1 (show MCL1 Proteins) stability contributes to the acquired resistance to cyclin-dependent kinase (show CDK1 Proteins) inhibitors in leukemia.

  8. Transcription is effective if RELA (show NFkBP65 Proteins) recruits the positive transcription elongation factor b (P-TEFb) component CDK9 to a combined RELA (show NFkBP65 Proteins)/STAT3 (show STAT3 Proteins) binding site -50 to -20bp upstream of the start site of the IL-12p35 promoter

  9. Thus, inhibition of CDK9 may represent an interesting approach as a cancer therapeutic target, especially in hematologic malignancies.

  10. MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9

Pig (Porcine) Cyclin-Dependent Kinase 9 (CDK9) interaction partners

  1. inhibition of CDK9 abrogated global transcriptional activity and rRNA production. Collectively, our data suggested that P-TEFb (show CCNT1 Proteins) kinase activity is crucial for oocyte maturation, embryo development and regulation of RNA transcription in pig.

Mouse (Murine) Cyclin-Dependent Kinase 9 (CDK9) interaction partners

  1. identified cyclin-dependent kinase 9 (Cdk9) as required for hepatocellular carcinoma disease maintenance

  2. This study demonstrates that Ikaros (show IKZF1 Proteins) directly interacts with GATA1 (show GATA1 Proteins), GATA2 (show GATA2 Proteins), and GATA3 (show GATA3 Proteins) as well as Cdk9/P-TEFb through specific protein domains.

  3. Data show that the minimal 90-amino acid AF9 (show MLLT3 Proteins) fragment in MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) retains an ability to form higher order complexes with AF4*P-TEFb (show CCNT1 Proteins) and with DOT1 (show DOT1L Proteins).

  4. Data show that the CDK9 and cyclin T1 (show CCNT1 Proteins) subunits of P-TEFb (show CCNT1 Proteins) are present in mouse oocytes and preimplantation embryos, and that CDK9 is essential for embryonic genome activation in the mouse.

  5. The present study examined whether Cdk9 forms a complex with GATA4 (show GATA4 Proteins) in mouse embryonic stem cells and is involved in their differentiation into cardiomyocytes.

  6. Data report that a second cdk9 isoform, termed cdk9-55, plays a fundamental role in muscle regeneration and differentiation in vivo.

  7. role in activating MyoD (show MYOD1 Proteins)-dependent transcription

  8. CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 (show CCNT1 Proteins) promotes its nuclear localization.

  9. chronic activation of Cdk9 causes not only cardiomyocyte enlargement but also defective mitochondrial function, via diminished PGC-1 transcription, and a resulting susceptibility to apoptotic cardiomyopathy

  10. PPARgamma (show PPARG Proteins)-cdk9 interaction results in increased transcriptional activity of PPARgamma (show PPARG Proteins) and therefore increased adipogenesis.

Zebrafish Cyclin-Dependent Kinase 9 (CDK9) interaction partners

  1. The balance of Cdk9 and Larp7 (show LARP7 Proteins) plays a key role in cardiomyocyte proliferation and response to injury

CDK9 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.

Alternative names and synonyms associated with CDK9

  • Cyclin-dependent kinase 9 (Cdk9)
  • cyclin-dependent kinase 9 (CDK9)
  • cyclin-dependent kinase 9 (cdk9)
  • cyclin-dependent kinase 9 (Cdk9)
  • cyclin-dependent kinase 9 (cdk9-a)
  • cyclin-dependent kinase 9 (CDC2-related kinase) (Cdk9)
  • cyclin-dependent kinase 9 (CDC2-related kinase) (cdk9)
  • cyclin-dependent kinase 9-like (LOC100855805)
  • C-2k protein
  • CDC2L4 protein
  • cdk9 protein
  • CG5179 protein
  • CTK1 protein
  • Dmel\\CG5179 protein
  • P-TEF protein
  • P-TEFb protein
  • PITALRE protein
  • PTefb protein
  • TAK protein
  • wu:fb22e09 protein
  • wu:fc06c02 protein

Protein level used designations for CDK9

CG5179-PA , Cdk9-PA , Cyclin-dependent kinase9 2.7 , p43 PITALRE , positive transcription elongation factor b , positive transcription elongation factor b, small subunit , cyclin-dependent kinase 9 (CDC2-related kinase) , cell division protein kinase 9 , CDC2-related kinase , cell division cycle 2-like protein kinase 4 , serine/threonine protein kinase PITALRE , serine/threonine-protein kinase PITALRE , tat-associated kinase complex catalytic subunit , cell division protein kinase 9-A , cyclin-dependent kinase 9-A , cyclin-dependent kinase 9

GENE ID SPECIES
37586 Drosophila melanogaster
464755 Pan troglodytes
448039 Xenopus (Silurana) tropicalis
1025 Homo sapiens
362110 Rattus norvegicus
735101 Xenopus laevis
417226 Gallus gallus
100307051 Sus scrofa
520580 Bos taurus
100725846 Cavia porcellus
101109788 Ovis aries
107951 Mus musculus
321602 Danio rerio
100855805 Canis lupus familiaris
491325 Canis lupus familiaris
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