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anti-Human CDKL3 Antibodies:
anti-Mouse (Murine) CDKL3 Antibodies:
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These results provided evidence supporting the oncogenic potential of NFAT3 (show NFATC4 Antibodies) and suggested that CDK3 (show CDK3 Antibodies)-mediated phosphorylation of NFAT3 (show NFATC4 Antibodies) has an important role in skin tumorigenesis.
The analysis of tumor and matched normal lung tissues indicates that miR (show MLXIP Antibodies)-150 downregulation in lung tumors correlates with higher CDK3 (show CDK3 Antibodies) levels. In addition, miR (show MLXIP Antibodies)-150 transfection experiments with cancer-derived cell lines reveal that miR (show MLXIP Antibodies)-150-mediated CDK3 (show CDK3 Antibodies) suppression directly induces growth inhibition.
High Cdk3 (show CDK3 Antibodies)-promoted epithelial-mesenchymal transition through activating AP-1 (show FOSB Antibodies) is involved in colorectal cancer metastasis.
Data indicate that microRNA miR (show MLXIP Antibodies)-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) through inhibition of E2F2 transcription factor (E2F2 (show E2F2 Antibodies)), cyclin (show PCNA Antibodies)-dependent kinases CDK3 (show CDK3 Antibodies) and CDK6 (show CDK6 Antibodies).
Mir (show MLXIP Antibodies)-873 inhibits ESR1 (show ESR1 Antibodies) activity and cell growth via targeting CDK3 (show CDK3 Antibodies).
CDK3 (show CDK3 Antibodies) is associated with the progression of NPC (show NPC1 Antibodies), and may be a potential biomarker for prediction of the prognosis of patients with NPC (show NPC1 Antibodies).
The Walleye dermal sarcoma virus cyclin (show PCNA Antibodies) functions as a structural ortholog of cyclin C (show CCNC Antibodies) in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 (show CDK8 Antibodies) and Cdk3 (show CDK3 Antibodies).
NKIAMRE is a member of a conserved family of kinases with homology to both MAP kinases and cyclin (show PCNA Antibodies)-dependent kinases
cdkl3 transfected in anchorage-independent (suspension) HeLa cells overexpressed relative to attached cells and lead to elevated proliferation and faster transition G0/G1 phases to S phase relative to controls. Same in two HEK (show EPHA3 Antibodies)-293 and a CHO (show COL11A1 Antibodies) cell lines.
data suggest that the CDKL3 gene is a strong candidate for nonsyndromal autosomal dominant mild mental retardation
Results indicated that CDKL3 may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
CDKL3 is involved in neuronal morphogenesis during development.
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms.
cyclin-dependent kinase-like 3
, cell division protein kinase 3
, serine-threonine protein kinase NKIAMRE
, serine/threonine-protein kinase NKIAMRE
, serine/threonine kinase NKIATRE beta
, serine/threonine protein kinase NKIATRE