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Mir (show MLXIP Proteins)-873 inhibits ESR1 (show ESR1 Proteins) activity and cell growth via targeting CDK3 (show CDK3 Proteins).
CDK3 (show CDK3 Proteins) is associated with the progression of NPC (show NPC1 Proteins), and may be a potential biomarker for prediction of the prognosis of patients with NPC (show NPC1 Proteins).
The Walleye dermal sarcoma virus cyclin (show PCNA Proteins) functions as a structural ortholog of cyclin C (show CCNC Proteins) in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 (show CDK8 Proteins) and Cdk3 (show CDK3 Proteins).
A non-cdk8 (show CDK8 Proteins)-associated cellular pool of cyclin C (show CCNC Proteins) combines with cdk3 (show CDK3 Proteins) to stimulate pRb (show RB1 Proteins) phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
Expression level of cdk3 (show CDK3 Proteins) is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 (show CDK3 Proteins) phosphorylates activating transcription factor 1 (ATF1 (show AFT1 Proteins))and enhances the transactivation and transcriptional activities of ATF1 (show AFT1 Proteins).
NKIAMRE is a member of a conserved family of kinases with homology to both MAP kinases and cyclin (show PCNA Proteins)-dependent kinases
cdkl3 transfected in anchorage-independent (suspension) HeLa cells overexpressed relative to attached cells and lead to elevated proliferation and faster transition G0/G1 phases to S phase relative to controls. Same in two HEK-293 and a CHO cell lines.
data suggest that the CDKL3 gene is a strong candidate for nonsyndromal autosomal dominant mild mental retardation
Results indicated that CDKL3 may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
CDKL3 is involved in neuronal morphogenesis during development.
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms.
cyclin-dependent kinase-like 3
, cell division protein kinase 3
, serine-threonine protein kinase NKIAMRE
, serine/threonine-protein kinase NKIAMRE
, serine/threonine kinase NKIATRE beta
, serine/threonine protein kinase NKIATRE