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These findings demonstrated that p21 plays a critical role in furazolidone-induced apoptosis in HepG2 cells by influencing the caspase-3 (show CASP3 ELISA Kits) activation and ROS (show ROS1 ELISA Kits) generation.
results suggested that high CDKN1A/p21 and low TGFBR2 (show TGFBR2 ELISA Kits) expression was closely correlated with adverse pathological parameters and poor prognosis in breast cancer.
Study provides evidence that miR (show MLXIP ELISA Kits)-208a can affect the proliferation and radio-sensitivity of human lung cancer cells by targeting p21.
Neisseria meningitidis caused changes in the abundance of several cell cycle regulatory mRNAs, including the cell cycle inhibitors p21(WAF1/CIP1) and cyclin G2 (show CCNG2 ELISA Kits) in human brain microvascular endothelial cells.
Estrogen-related receptor gamma (show ESRRG ELISA Kits) is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27 (show PAK2 ELISA Kits).
accumulation of HDAC4 (show HDAC4 ELISA Kits) induced by fibrillar collagen matrices in the nucleus via co-localization of PP1alpha (show PPP1CA ELISA Kits), leads to repression of the mRNA/protein of p21 and in turn promotes the proliferation and migration of epithelial ovarian cancer cells
Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21, p27 (show PAK2 ELISA Kits)-cyclin E (show CCNE1 ELISA Kits),A/Cdk2 (show CDK2 ELISA Kits) pathway.
Suggest that the p53 (show TP53 ELISA Kits)-p21-DREAM-CDE/CHR pathway regulates p53 (show TP53 ELISA Kits)-dependent repression of Survivin (show BIRC5 ELISA Kits), CDC25C (show CDC25C ELISA Kits), and PLK1 (show PLK1 ELISA Kits) in HCT116 cells.
Overexpression of miR (show MLXIP ELISA Kits)-512-5p led to the decrease of p21 protein (show NRAS ELISA Kits).
Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B ELISA Kits) formation upstream of AMP-activated protein kinase (show PRKAA2 ELISA Kits) and protein kinase (show CDK7 ELISA Kits) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (show DDIT3 ELISA Kits) pathways and p21 Cip1 expression.
The lack of functional Waf1 is indispensable for maintaining self-renewal and pluripotency of embryonic stem cells.
p27(Kip1 (show CDKN1B ELISA Kits)) and p21(Cip1) are insufficient for the proliferative inhibition of smooth muscle cells cultured in type 1 collagen.
Foxo3 (show FOXO3 ELISA Kits) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 (show CDK2 ELISA Kits).
TFAP2C (show TFAP2C ELISA Kits) in trophoblasts controls proliferation by repressing Cdkn1a and activating the MAPK (show MAPK1 ELISA Kits) pathway, further supporting differentiation of glycogen (show GYS1 ELISA Kits) cells by activating the AKT (show AKT1 ELISA Kits) pathway
Interaction between ASPM (show ASPM ELISA Kits) and the Cdk2 (show CDK2 ELISA Kits)/Cyclin E (show CCNE1 ELISA Kits) complex regulated the Cyclin (show PCNA ELISA Kits) activity by modulating its ubiquitination and localization into the nucleus.
we present evidence that VPA administration to mice increases hippocampal p21 expression, accompanied by DNA demethylation at the distal CpG island.
LKB1 (show STK11 ELISA Kits) mediates CDKN1A degradation in response to ultraviolet DNA damage.
At high glucose concentrations in vitro, AdipoR1 (show ADIPOR1 ELISA Kits) regulated the survival of neural stem cells through the p53 (show TP53 ELISA Kits)/p21 pathway and the proliferation- and differentiation-related factors of neural stem cells via TLX (show NR2E1 ELISA Kits).
Phosphorylation of p53 (show TP53 ELISA Kits) by LRRK2 (show LRRK2 ELISA Kits) induces p21(WAF1/CIP1) expression and apoptosis.
AMP-18 (show GKN1 ELISA Kits) appears to act through PI3K/AKT (show AKT1 ELISA Kits) pathways to increase p21 phosphorylation, thereby reducing its nuclear accumulation to overcome the antiproliferative effects of TNF-alpha (show TNF ELISA Kits).
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
CDK-interacting protein 1
, CDK-interaction protein 1
, DNA synthesis inhibitor
, cyclin-dependent kinase inhibitor 1
, melanoma differentiation associated protein 6
, wild-type p53-activated fragment 1
, melanoma differentiation-associated protein