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PCTAIRE1 (show CDK16 Proteins) has a role in regulating p27 (show PAK2 Proteins), c-Myc (show MYC Proteins) levels and tumor growth in cutaneous cutaneous squamous cell carcinoma cells
Low P27KIP1 expression is associated with Non Small Cell Lung Cancer.
Results show that that Id2 was directly upregulated by BMP4 (show BMP4 Proteins), resulting in the mediated expression of cell cycle regulatory protein (show RCC1 Proteins) of CDKN1B.
p27 (show PAK2 Proteins) and its cognate ubiquitin ligases, Skp2/KPC/Pirh2 (show RCHY1 Proteins), are specifically involved in determining the clinical profiles of lung carcinomas.
In thyroid cancer cells, oncogene (show RAB1A Proteins) activation prevented TGF-beta (show TGFB1 Proteins)/SMAD (show SMAD1 Proteins)-dependent p27 (show PAK2 Proteins) repression, and CDK2 (show CDK2 Proteins)/SMAD3 (show SMAD3 Proteins) phosphorylation, leading to p65 (show GORASP1 Proteins) NFkappaB (show NFKB1 Proteins) upregulation which repressed BAX (show BAX Proteins), induced cyclin D1 (show CCND1 Proteins) and promoted TGF-beta (show TGFB1 Proteins)-dependent growth.
PTEN loss and p27 (show PAK2 Proteins) loss differ among morphologic patterns of prostate cancer.
abnormal levels of Skp2 and p27(KIP1) have probably been involved in the pathogenesis of ADH (show AVP Proteins) and DCIS. Thus, Skp2 and p27(KIP1) may serve as important diagnosis markers.
Results suggest that interaction of CIB1 with alphaIIb is one of the early events occurring during outside-in signaling. Furthermore, CIB1 recruits FAK to the alphaIIbbeta3 complex at the filopodia where FAK is activated, which in turn activates c-Src, resulting in propagation of outside-in signaling leading to platelet spreading.
Cip2a (show KIAA1524 Proteins) markedly decreased the expression and nuclear localization of p27Kip1 and this is critical for the ability of Cip2a (show KIAA1524 Proteins) to promote Triple-negative breast cancer progression.
These results indicate that the dynamic interplay between O-GlcNAcylation and cyclin dependent kinase inhibitor p27 phosphorylation coordinates and regulates cell proliferation in hepatocellular carcinoma.
Study reports that p27 normally exerts a negative feedback on p21 expression: p27 directly represses the expression of the transcription factor Pitx2 (show PITX2 Proteins) which in turn maintains decreased p21 levels. Consequently, in cells lacking p27, de-repression of Pitx2 (show PITX2 Proteins) causes the up-regulation of p21 showing a new mechanism by which p27 regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (show PITX2 Proteins) and p21.
Fbxo7 (show FBXO7 Proteins)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 (show CDK6 Proteins) activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 (show FBXO7 Proteins) at different stages in T-cell development.
systems-level control of cell cycle arrest by pRB (show PGR Proteins)-E2F (show E2F1 Proteins) and p27-CDK (show CDK4 Proteins) regulation, is reported.
Results demonstrated that the addition of oncogenic mutations, such as loss of p27 or p53 (show TP53 Proteins), promotes ovarian tumor development from the benign adenomas of germ cell-deficient (show FANCL Proteins) ovaries.
p27 inactivation promotes injury islet graft loss via the elevation of proliferation and inflammatory cytokines secretion in infiltrating macrophages which induced nonspecific inflammation independent of TNF-alpha (show TNF Proteins)/nuclear factor-kappa b pathway. T
Knockout of p27 enhances arterial collateralization in response to hindlimb ischemia through enlargement of a new collateral pathway.
These data illuminate a genetic pathway that initiates auditory HC regeneration and suggest p27(Kip1), GATA3 (show GATA3 Proteins), and POU4F3 (show POU4F3 Proteins) as additional therapeutic targets for ATOH1 (show ATOH1 Proteins)-mediated auditory hair cells regeneration.
Cdkn1b exert its effects via the inhibition of proliferation and is mediated by miR (show MLXIP Proteins)-24 and targeted by the transcription factors FOXO4 (show FOXO4 Proteins) and AP4 (show REPIN1 Proteins) in the peroxidasin (Pxdn (show PXDN Proteins)) mutation-induced eye disorders, such as glaucoma.
These results suggest that fad24 (show NOC3L Proteins) may have an important role in the S phase re-entry of quiescent C2C12 cells through the regulation of p27(Kip1) at the protein level
The down-regulation of p27 and the activation of mTOR (show FRAP1 Proteins) pathway may be involved in miR (show MLXIP Proteins)-222-induced heart failure and autophagy inhibition.
FoxO1a (show FOXO1 Proteins) can regulate p27kip nuclear localization
the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells.
p27Kip1 inhibition has an effect on proliferation of bovine corneal endothelial cells by RNA interferenc
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry (By similarity).
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor 1B
, DNA-PK interaction protein
, DNA-PKcs-interacting protein
, DNA-dependent protein kinase interacting protein
, SNK-interacting protein 2-28
, calcium and integrin-binding protein 1
, Cyclin-dependent kinase inhibitor p27
, cyclin-dependent kinase inhibitor p27
, Cyclin-dependent kinase inhibitor 1B (p27 Kip1)
, Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor p27/Kip1
, cyclin-dependent kinase inhibitor 1b, like
, cyclin-dependent kinase inhibitor 1b (p27, kip1)
, interferon alpha-induced 11.5 kDa protein
, interferon alpha-inducible protein 27, mitochondrial
, interferon-stimulated gene 12a protein
, 26S proteasome non-ATPase regulatory subunit 9
, 26S proteasome regulatory subunit p27