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some cancer cells are defective for efficient interaction between p27 (show PAK2 Proteins) and CycA (show CCNA2 Proteins)-CDK (show CDK4 Proteins) complex due to qualitative alteration(s)
p27(kip1) overexpression regulates IL-1beta (show IL1B Proteins) in the microenvironment of stem cells and eutopic endometriosis
Data suggest that NOX5 (show NOX5 Proteins) expression in melanoma cells could contribute to cell proliferation due, in part, to the generation of high local concentrations of extracellular ROS (show ROS1 Proteins) that modulate multiple pathways that regulate HIF-1alpha (show HIF1A Proteins) and networks that signal through Akt (show AKT1 Proteins)/GSK3beta/p27(Kip1) .
SNHG6 acted as an oncogene (show RAB1A Proteins) in gastric cancer cells through regulating miR (show MLXIP Proteins)-101-3p/ZEB1 at a post-transcriptional level and silencing expression at a transcriptional level by recruiting enhancer of zeste homolog 2 (EZH2 (show EZH2 Proteins)) to the promoter of p27 (show PAK2 Proteins).
PCTAIRE1 (show CDK16 Proteins) has a role in regulating p27 (show PAK2 Proteins), c-Myc (show MYC Proteins) levels and tumor growth in cutaneous cutaneous squamous cell carcinoma cells
Low P27KIP1 expression is associated with Non Small Cell Lung Cancer.
Results show that that Id2 was directly upregulated by BMP4 (show BMP4 Proteins), resulting in the mediated expression of cell cycle regulatory protein (show RCC1 Proteins) of CDKN1B.
p27 (show PAK2 Proteins) and its cognate ubiquitin ligases, Skp2/KPC/Pirh2 (show RCHY1 Proteins), are specifically involved in determining the clinical profiles of lung carcinomas.
In thyroid cancer cells, oncogene (show RAB1A Proteins) activation prevented TGF-beta (show TGFB1 Proteins)/SMAD (show SMAD1 Proteins)-dependent p27 (show PAK2 Proteins) repression, and CDK2 (show CDK2 Proteins)/SMAD3 (show SMAD3 Proteins) phosphorylation, leading to p65 (show GORASP1 Proteins) NFkappaB (show NFKB1 Proteins) upregulation which repressed BAX (show BAX Proteins), induced cyclin D1 (show CCND1 Proteins) and promoted TGF-beta (show TGFB1 Proteins)-dependent growth.
PTEN loss and p27 (show PAK2 Proteins) loss differ among morphologic patterns of prostate cancer.
p27Kip1 inhibition has an effect on proliferation of bovine corneal endothelial cells by RNA interferenc
FoxO1a (show FOXO1 Proteins) can regulate p27kip nuclear localization
the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells.
Our results revealed that CKS1 (show CKS1B Proteins) is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability.
p27kip1 is involved in the decisive step around cell-cycle exit and plays an important role in activity-regulated and functionally relevant adult hippocampal neurogenesis.
p27(Kip1)-target genes are involved in cell adhesion and cell signaling in mouse embryonic fibroblasts.
This study demonstrates that LMP2A uses the role of MYC (show MYC Proteins) in the cell cycle, particularly in the p27(kip1) degradation process, to accelerate lymphomagenesis in vivo.
Study reports that p27 normally exerts a negative feedback on p21 expression: p27 directly represses the expression of the transcription factor Pitx2 (show PITX2 Proteins) which in turn maintains decreased p21 levels. Consequently, in cells lacking p27, de-repression of Pitx2 (show PITX2 Proteins) causes the up-regulation of p21 showing a new mechanism by which p27 regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (show PITX2 Proteins) and p21.
Fbxo7 (show FBXO7 Proteins)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 (show CDK6 Proteins) activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 (show FBXO7 Proteins) at different stages in T-cell development.
systems-level control of cell cycle arrest by pRB (show PGR Proteins)-E2F (show E2F1 Proteins) and p27-CDK (show CDK4 Proteins) regulation, is reported.
Results demonstrated that the addition of oncogenic mutations, such as loss of p27 or p53 (show TP53 Proteins), promotes ovarian tumor development from the benign adenomas of germ cell-deficient (show FANCL Proteins) ovaries.
p27 inactivation promotes injury islet graft loss via the elevation of proliferation and inflammatory cytokines secretion in infiltrating macrophages which induced nonspecific inflammation independent of TNF-alpha (show TNF Proteins)/nuclear factor-kappa b pathway. T
Knockout of p27 enhances arterial collateralization in response to hindlimb ischemia through enlargement of a new collateral pathway.
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
cyclin-dependent kinase inhibitor 1B
, cyclin-dependent kinase inhibitor 1b (p27, kip1)
, cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor p27
, Cyclin-dependent kinase inhibitor 1B (p27 Kip1)
, Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor p27/Kip1
, Cyclin-dependent kinase inhibitor p27
, cyclin-dependent kinase inhibitor 1b, like