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intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 ELISA Kits), wee1 (show WEE1 ELISA Kits), p21 (show CDKN1A ELISA Kits), PCNA (show PCNA ELISA Kits) and cdk2 (show CDK2 ELISA Kits), but only weakly influences cyclin B1, cyclin B2 (show CCNB2 ELISA Kits) and cyclin E1 (show CCNE1 ELISA Kits) expression.
the sequence in the coding region of cyclin B1 mRNA plays an important role as a cis (show CISH ELISA Kits)-acting element in both subcellular localization and translational timing of mRNA
Reporter mRNAs with the whole cyclin B1 sequence precisely mimic the localization & translation of endogenous cyclin B1 mRNA. mRNAs containing cyclin B1 3' UTR (show UTS2R ELISA Kits) but lacking ORFs had abnormal localization & precocious translational activation.
zebrafish cyclin B1 3'UTR (show UTS2R ELISA Kits) was quantitatively less effective at stimulating polyadenylation and translation compared to the Xenopus cyclin B1 3'UTR (show UTS2R ELISA Kits) during both zebrafish and Xenopus oocyte maturation
Data show that CDK1 (show CDK1 ELISA Kits) and cyclin B synergize during oocyte maturation to inhibit Myt1 (show PKMYT1 ELISA Kits) ensuring meiotic progression.
new role for Erk (show MAPK1 ELISA Kits) in mitotic regulation, identification of the Ser (show SIGLEC1 ELISA Kits) 101-directed kinase, and a picture of cyclin B1/Cdc2 regulation by the combinatorial action of distinct kinases
Cyclin B1 displays cytoskeleton-dependent localization in blastomere cortex during Xenopus embryonic cell cycle.
Cyclin B dissociation from CDK1 (show CDK1 ELISA Kits) precedes cyclins B degradation upon CDK1 (show CDK1 ELISA Kits) inactivation in mitotic embryo extracts and that proteasome proteolytic activity is dispensable for both activation and inactivation of CDK1 (show CDK1 ELISA Kits) in such extracts.
On analyzing cyclin A (show CCNA2 ELISA Kits) and B1 (CCNA (show CCNA2 ELISA Kits) and CCNB1) expression, positive staining in 90% cases of PTC (show F9 ELISA Kits) were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC (show F9 ELISA Kits).
Sodium butyrate accelerates 3' UTR (show UTS2R ELISA Kits)-dependent cyclin B1 decay by enhancing the binding of tristetraprolin (show ZFP36 ELISA Kits) to the 3' untranslated region of cyclin B1.
CDK1-Cyclin B1 activates RNMT, coordinating mRNA cap methylation with G1 phase transcription.
Our results demonstrate for the first time that the SYSADOA diacerein decreased the viability of human chondrosarcoma cells and induces G2/M cell cycle arrest by CDK1 (show CDK1 ELISA Kits)/cyclin B1 down-regulation.
CCNB1 is target of miRNA-410 since its overexpression reduces CCNB1 at protein and mRNA levels.
Germ cell tumors consistently overexpressed cyclin B1 independently of their responsiveness to chemotherapy or the presence of p53 (show TP53 ELISA Kits) mutations. Cyclin B1 was overexpressed by GCT (show QPCT ELISA Kits) cell lines carrying functional p53 (show TP53 ELISA Kits).
The authors postulate that the mechanism of cytomegalovirus pUL97-human cyclin B1 interaction is determined by an active pUL97 kinase domain.
Stereospecific phosphorylation of only the Ser (show SIGLEC1 ELISA Kits)-trans-Pro peptide by Cdk1 (show CDK1 ELISA Kits)-cyclin B1
Pharmacological inhibition or siRNA-mediated knockdown of cdk1 (show CDK1 ELISA Kits)/CCNB1 induced proliferation arrest independent of MYCN (show MYCN ELISA Kits) status in neuroblastoma (show ARHGEF16 ELISA Kits) cells.
Expression of CDK1 (show CDK1 ELISA Kits) Tyr15, pCDK1 Thr161, Cyclin B1 (total) and pCyclin B1 Ser126 in vulvar squamous cell carcinoma and their relations with clinicopatological features and prognosis.
AURKA (show AURKA ELISA Kits) induced phosphorylation and recruitment of CDC25B (show CDC25B ELISA Kits) to MTOCs prior to p-Cyclin B1-Ser123, and this sequential regulation is essential for the commitment of the oocytes to resume meiosis.
that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression
Parvovirus-induced depletion of cyclin B1 prevents mitotic entry of infected cells.
Cyclin B1/Cdk1 (show CDK1 ELISA Kits)-mediated phosphorylation of mitochondrial substrates allows cells to sense and respond to increased energy demand for G2/M transition and, subsequently, to upregulate mitochondrial respiration for successful cell-cycle progression.
sticky siRNAs against survivin (show BIRC5 ELISA Kits) and cyclin B1 efficiently blocks growth of established subcutaneaous B16-F10 (show F10 ELISA Kits) tumors as well as formation and dissemination of melanoma lung metastases.
Inhibitions of Aurora B (show AURKC ELISA Kits) and Cyclin-dependent kinase 1 (show CDK1 ELISA Kits) activity in vertebrate cells also have opposite effects on the timing of abscission.
It was concluded that insensitivity of mouse germinal vesicle oocytes to cyclohexidine was due to the presence of sufficient cyclin B1, and that cyclin B1 level in such oocytes was maintained by an equilibrium between synthesis and degradation.
Data show nuclear accumulation of cyclin B1 with a subsequent premature increase in G2/M kinase activity in Nipa (show ZC3HC1 ELISA Kits)-/- spermatocytes.
Data show that Cyclin B1 is synchronously degraded in whole oocytes and oocyte halves with a single bivalent
Data show that protein expression of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4 was downregulated upon LXR activation.
cyclin B1 distribution in porcine oocytes is affected by demecolcine-assisted enucleation
germinal vesicle is not required for the activation of M phase promoting factor during the first meiosis, but it is required for the second meiosis because of its promotion of CCNB1 accumulation
Results describe the expression of maternal cyclin B1 and Cdc2 (show CDK1 ELISA Kits) during in vitro maturation of porcine oocytes.
Cyclin-dependent kinase (show CDK1 ELISA Kits) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (show MSLN ELISA Kits)) and MAPK (show MAPK1 ELISA Kits), and had nearly no effect on kinase activities during maturation.
link between cytoplasmic polyadenylation of cyclin B1 and translation/appearance of cyclin B1 protein before in vitro maturation of oocytes
Polyadenylation of cyclin B1 was also completely prevented when 3'-dA was added at 0 hr, and greatly reduced when added at 6 hr
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.
, cyclin B1
, cyclin B4
, G2/mitotic-specific cyclin B1
, cyclin B1, related sequence 1
, cyclin B1, related sequence 13
, cyclin B