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Human Cyclin B1 Protein expressed in Wheat germ - ABIN1348434
Lacombe, Mangé, Bougnoux, Prassas, Solassol: A multiparametric serum marker panel as a complementary test to mammography for the diagnosis of node-negative early-stage breast cancer and DCIS in young women. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA (show PCNA Proteins) and cdk2 (show CDK2 Proteins), but only weakly influences cyclin B1, cyclin B2 (show CCNB2 Proteins) and cyclin E1 (show CCNE1 Proteins) expression.
the sequence in the coding region of cyclin B1 mRNA plays an important role as a cis (show CISH Proteins)-acting element in both subcellular localization and translational timing of mRNA
Reporter mRNAs with the whole cyclin B1 sequence precisely mimic the localization & translation of endogenous cyclin B1 mRNA. mRNAs containing cyclin B1 3' UTR but lacking ORFs had abnormal localization & precocious translational activation.
zebrafish cyclin B1 3'UTR was quantitatively less effective at stimulating polyadenylation and translation compared to the Xenopus cyclin B1 3'UTR during both zebrafish and Xenopus oocyte maturation
Data show that CDK1 (show CDK1 Proteins) and cyclin B synergize during oocyte maturation to inhibit Myt1 (show PKMYT1 Proteins) ensuring meiotic progression.
new role for Erk (show MAPK1 Proteins) in mitotic regulation, identification of the Ser (show SIGLEC1 Proteins) 101-directed kinase, and a picture of cyclin B1/Cdc2 regulation by the combinatorial action of distinct kinases
Cyclin B1 displays cytoskeleton-dependent localization in blastomere cortex during Xenopus embryonic cell cycle.
Cyclin B dissociation from CDK1 (show CDK1 Proteins) precedes cyclins B degradation upon CDK1 (show CDK1 Proteins) inactivation in mitotic embryo extracts and that proteasome proteolytic activity is dispensable for both activation and inactivation of CDK1 (show CDK1 Proteins) in such extracts.
XIAP (show XIAP Proteins) is stable during mitotic arrest, but its function is controlled through phosphorylation by the mitotic kinase CDK1 (show CDK1 Proteins)-cyclin-B1 at S40.
ZIC5 is highly upregulated in non-small cell lung cancer tumor tissues and may act as an oncogene (show RAB1A Proteins) by influencing CCNB1 and CDK1 (show CDK1 Proteins) complex expression
Knockdown of DRG2 (show DRG2 Proteins) elicited down-regulation of the major mitotic promoting factor, the cyclin B1/Cdk1 (show CDK1 Proteins) complex.
Mitochondrial Ribosomal Protein L10 regulates cyclin B1/Cdk1 (cyclin-dependent kinase 1 (show CDK1 Proteins)) activity and mitochondrial protein (show COX6B2 Proteins) synthesis in mammalian cells
Changes in expression and localization of cyclin B1 may constitute a part of the mechanism responsible for resistance of HL-60 cells to etoposide.
Data suggest that long non-coding RNA ZFAS1 may function as oncogene (show RAB1A Proteins) via destabilization of tumor suppressor protein p53 (p53 (show TP53 Proteins)) and through cyclin-dependent kinase 1 (CDK1 (show CDK1 Proteins))/cyclin B1 complex leading to cell cycle progression and inhibition of apoptosis.
exposing renal carcinoma cells to amygdalin inhibited cell cycle progression and tumor cell growth by impairing cdk1 (show CDK1 Proteins) and cyclin B expression
Together, these results demonstrate that PGC-1alpha regulates cell cycle progression through modulation of CyclinD1 and CyclinB1 by ATP and ROS (show ROS1 Proteins).
On analyzing cyclin A (show CCNA2 Proteins) and B1 (CCNA (show CCNA2 Proteins) and CCNB1) expression, positive staining in 90% cases of PTC (show F9 Proteins) were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC (show F9 Proteins).
Sodium butyrate accelerates 3' UTR-dependent cyclin B1 decay by enhancing the binding of tristetraprolin (show ZFP36 Proteins) to the 3' untranslated region of cyclin B1.
Inhibition of CDK7 (show CDK7 Proteins) bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.
timing of Ccnb1 mRNA translation in mouse oocytes is dependent on the presence of transcripts with different 3' untranslated regions
AURKA (show AURKA Proteins) induced phosphorylation and recruitment of CDC25B (show CDC25B Proteins) to MTOCs prior to p-Cyclin B1-Ser123, and this sequential regulation is essential for the commitment of the oocytes to resume meiosis.
that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression
Parvovirus-induced depletion of cyclin B1 prevents mitotic entry of infected cells.
Cyclin B1/Cdk1 (show CDK1 Proteins)-mediated phosphorylation of mitochondrial substrates allows cells to sense and respond to increased energy demand for G2/M transition and, subsequently, to upregulate mitochondrial respiration for successful cell-cycle progression.
sticky siRNAs against survivin (show BIRC5 Proteins) and cyclin B1 efficiently blocks growth of established subcutaneaous B16-F10 (show F10 Proteins) tumors as well as formation and dissemination of melanoma lung metastases.
Inhibitions of Aurora B (show AURKC Proteins) and Cyclin-dependent kinase 1 (show CDK1 Proteins) activity in vertebrate cells also have opposite effects on the timing of abscission.
It was concluded that insensitivity of mouse germinal vesicle oocytes to cyclohexidine was due to the presence of sufficient cyclin B1, and that cyclin B1 level in such oocytes was maintained by an equilibrium between synthesis and degradation.
Data show nuclear accumulation of cyclin B1 with a subsequent premature increase in G2/M kinase activity in Nipa (show ZC3HC1 Proteins)-/- spermatocytes.
Cyclin B1 plays a significant role in promoting the maturation of large-follicle oocytes.
cyclin B1 distribution in porcine oocytes is affected by demecolcine-assisted enucleation
germinal vesicle is not required for the activation of M phase promoting factor during the first meiosis, but it is required for the second meiosis because of its promotion of CCNB1 accumulation
Results describe the expression of maternal cyclin B1 and Cdc2 (show CDK1 Proteins) during in vitro maturation of porcine oocytes.
Cyclin-dependent kinase (show CDK1 Proteins) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (show MSLN Proteins)) and MAPK (show MAPK1 Proteins), and had nearly no effect on kinase activities during maturation.
link between cytoplasmic polyadenylation of cyclin B1 and translation/appearance of cyclin B1 protein before in vitro maturation of oocytes
Polyadenylation of cyclin B1 was also completely prevented when 3'-dA was added at 0 hr, and greatly reduced when added at 6 hr
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.
, cyclin B1
, cyclin B4
, G2/mitotic-specific cyclin B1
, cyclin B1, related sequence 1
, cyclin B1, related sequence 13
, cyclin B