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intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 ELISA Kits), wee1 (show WEE1 ELISA Kits), p21 (show CDKN1A ELISA Kits), PCNA (show PCNA ELISA Kits) and cdk2 (show CDK2 ELISA Kits), but only weakly influences cyclin B1 (show CCNB1 ELISA Kits), cyclin B2 and cyclin E1 (show CCNE1 ELISA Kits) expression.
These results demonstrate that the proper localization of cyclin B2 is essential for bipolar spindle formation in Xenopus oocytes.
These results show that ElrA and AUF1 (show HNRNPD ELISA Kits) bind to cyclin B2 mRNA independent of cytoplasmic polyadenylation elements and function by binding other elements.
Data show that the cyclin B2 was overexpressed in bladder cancer tissue.
overexpression of CCNB2 protein is associated with clinical progression and poor prognosis in non-small cell lung cancer
Cyclin B1 (show CCNB1 ELISA Kits) and cyclin B2 are interchangeable for ability to promote G2 and M transition in HeLa cells.
there was no significance in the 5-year overall survival rates among the patients with squamous cell carcinoma between expressing lower and higher level of cyclin B2 mRNA
Suggest that cytoplasmic CCNB2 may function as an oncogene (show RAB1A ELISA Kits) and could serve as a potential biomarker of unfavorable prognosis over short-term follow-up in breast cancer.
The radiosensitizing effect of paclitaxel on KB cells may be due to the down-regulated expression of PRC1 (show PRC1 ELISA Kits) and cyclin B2.
The relative expression level of circulating CCNB2 mRNA in cancer patients was significantly higher than that in normal controls and benign diseases group. Circulating CCNB2 mRNA level significantly correlated with cancer stage and metastasis status.
Data suggest that cyclin A2 (show CCNA2 ELISA Kits) helps initiate mitosis, in part through its effects on cyclin B1 (show CCNB1 ELISA Kits), and that cyclins B1 and B2 are particularly critical for the maintenance of the mitotic state.
p300 (show EP300 ELISA Kits) binds to multiple NF-Y trimers to regulate cyclin B2 promoter function
cyclin B2 expression in colorectal adenocarcinoma is dependent on NF-Y
Report roles for cyclin B2 and p53 (show TP53 ELISA Kits) in centrosome separation that may be perturbed in many human cancers.
Hec1 (show NDC80 ELISA Kits)-dependent cyclin B2 stabilization during early metaphase is important for early-stage spindle assembly.
Menin (show MEN1 ELISA Kits) may inhibit MEN1 (show MEN1 ELISA Kits) insulinoma (show RPS15 ELISA Kits) by suppressing cyclin B2 expression via histone modification.
this study identifies a correlation between the presence of AIRE and proteasomal breakdown of cyclin B2, which leads us to speculate that cyclin B2 could be a target of AIRE's E3-ubiquitin ligase activity
menin (show MEN1 ELISA Kits)-mediated repression of cyclin B2 is crucial for inhibiting G(2)/M transition and cell proliferation through a previously unrecognized molecular mechanism for menin (show MEN1 ELISA Kits)-induced suppression of MEN1 (show MEN1 ELISA Kits) tumorigenesis
an increased CCNB2 expression in human pituitary adenomas of different histotypes that is directly correlated with HMGA1 and HMGA2 expression.
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.
, cyclin B2
, G2/mitotic-specific cyclin B2