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The surface immune molecule CD274 (show CD274 ELISA Kits) plays a critical role in the proliferation of leukemia-initiating cells, LICs. The CD274 (show CD274 ELISA Kits)/JNK (show MAPK8 ELISA Kits)/Cyclin D2 pathway promotes the cell cycle entry of LIC.
High CCND2 expression is associated with Metastasis of Colorectal Cancer.
Mutation in the CCND2 gene is associated with acute myeloid leukemia (show BCL11A ELISA Kits).
data suggested that loss of CCND2 expression is closely associated with the promoter aberrant methylation
MiR (show MLXIP ELISA Kits)-497 significantly suppressed cell proliferation by arresting the cell cycle through the CCND2 protein.
cyclin D2 acts as regulator of cell cycle (show C13orf15 ELISA Kits) proteins affecting SAMHD1 (show SAMHD1 ELISA Kits)-mediated HIV-1 restriction in non-proliferating macrophages.
CCND2-AS1 (show PTGDR ELISA Kits) promotes glioma cells proliferation and growth in a process that involves Wnt (show WNT2 ELISA Kits) and beta-catenin (show CTNNB1 ELISA Kits)
CCND1 (show CCND1 ELISA Kits) is downregulated, whereas CCND2 is not, following ionizing radiation (IR) . Both CCND1 (show CCND1 ELISA Kits)- and CCND2-expressing MM cells arrested in S/G2 (show STRN3 ELISA Kits)/M, and did not differ in other cell-cycle proteins or sensitivity to IR.Differential expression of D-cyclin (show PCNA ELISA Kits) does not appear to affect cell-cycle response to IR, and is unlikely to underlie differential sensitivity to DNA damage.
the phosphorylation levels of ErbB2 (show ERBB2 ELISA Kits), ErbB3 (show ERBB3 ELISA Kits) and Akt (show AKT1 ELISA Kits) and the protein levels of cyclin D1 (show CCND1 ELISA Kits) were decreased by lapatinib treatment of HSC3, HSC4 and Ca9 (show CA9 ELISA Kits)-22 cells
miR (show MLXIP ELISA Kits)-155 overexpression plays a promoting role in the proliferative, migratory and invasive behavior of OSCC cells. Its effects on OSCC are possibly associated with its regulation of the BCL6 (show BCL6 ELISA Kits)/cyclin D2 axis.
Cyclin D1 (show CCND1 ELISA Kits) is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 (show CCND1 ELISA Kits) in hematopoiesis.
we analyzed Cyclin D2(-/-) mice to test whether the ciliary margin zone (CMZ)is a source of retinal cells. Neurogenesis is diminished in Cyclin D2 mutants, leading to a reduction of RGCs in the ventral retina. In line with these findings, in the albino retina, the decreased production of ipsilateral RGCs is correlated with fewer Cyclin D2(+) cells.
We showed for the first time that progesterone-induced miR (show MLXIP ELISA Kits)-133a inhibited the proliferation of endometrial epithelial cells by downregulating cyclinD2.
NMB or NMBR (show NMBR ELISA Kits) silencing inhibited M-CSF (show CSF1R ELISA Kits)/c-Fms (show CSF1R ELISA Kits)-mediated downstream signaling pathways like activation of ERK (show EPHB2 ELISA Kits) and Akt (show AKT1 ELISA Kits) and induction of D-type cyclins, cyclin D1 (show CCND1 ELISA Kits) and D2.
Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta (show PRKCZ ELISA Kits)) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (show INS ELISA Kits) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin (show FRAP1 ELISA Kits) protein) and Ccnd2 (cyclin-D2).
miR (show MLXIP ELISA Kits)-26a regulated mouse hepatocyte proliferation by directly targeting the 3' untranslated regions of cyclin D2/cyclin E2 (show CCNE2 ELISA Kits).
NF-kappaB (show NFKB1 ELISA Kits)-miR (show MLXIP ELISA Kits)-195/497-Igf1r (show IGF1R ELISA Kits)/Insr (show INSR ELISA Kits)-Ccnd2/Ccne1 (show CCNE1 ELISA Kits) plays important roles in myogenesis.
Loss of N-myc (show MYCN ELISA Kits) significantly impairs the Sonic hedgehog (show SHH ELISA Kits) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2.
Activation of the ERK1/2 (show MAPK1/3 ELISA Kits) signalling pathway, increased phosphorylation of c-myc (show MYC ELISA Kits) and significantly increased expression of cyclin D2 protein, are demonstrated.
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 (show PSEN1 ELISA Kits) genes via a STAT3 (show STAT3 ELISA Kits)-dependent pathway
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
, G1/S-specific cyclin-D2
, G1/S-specific cyclin D2
, vin-1 proto-oncogene