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the phosphorylation levels of ErbB2 (show ERBB2 ELISA Kits), ErbB3 (show ERBB3 ELISA Kits) and Akt (show AKT1 ELISA Kits) and the protein levels of cyclin D1 (show CCND1 ELISA Kits) were decreased by lapatinib treatment of HSC3, HSC4 and Ca9 (show CA9 ELISA Kits)-22 cells
miR (show MLXIP ELISA Kits)-155 overexpression plays a promoting role in the proliferative, migratory and invasive behavior of OSCC cells. Its effects on OSCC are possibly associated with its regulation of the BCL6 (show BCL6 ELISA Kits)/cyclin D2 axis.
Bioinformatics analysis further revealed cyclin D2 (CCND2) and AKT3 (show AKT3 ELISA Kits), putative tumor promoters, as potential targets of miR610. Data from reporter assays showed that miR610 directly binds to the 3'untranslated
this study shows that miR (show MLXIP ELISA Kits)-124-3p may negatively regulate the transcription of the STAT3 (show STAT3 ELISA Kits) by interfering with its 3'UTR (show UTS2R ELISA Kits), and the degradation of STAT3 (show STAT3 ELISA Kits) affects its downstream expression of such as p-STAT3 (show STAT3 ELISA Kits), CCND2 and MMP-2 (show MMP2 ELISA Kits)
these results highlight the impact of CCND2 3'UTR (show UTS2R ELISA Kits) shortening on miRNA-dependent regulation of CCND2 in multiple myeloma.
The results do not support our hypothesis that common germline genetic variants in the CCND2 genes is associated with the risk of developing medulloblastoma.
miR (show MLXIP ELISA Kits)-198 inhibited HaCaT cell proliferation by directly targeting CCND2.
CCND2 was identified as a putative target gene for SMYD3 (show SMYD3 ELISA Kits) transcriptional regulation, through trimethylation of H4K20.Our results support a proto-oncogenic role for SMYD3 (show SMYD3 ELISA Kits) in prostate carcinogenesis, mainly due to its methyltransferase enzymatic activity.
Treatment of rSCC-61 and SCC (show CYP11A1 ELISA Kits)-61 with the DNA hypomethylating agent 5-aza-2'deoxycitidine increased CCND2 levels only in rSCC-61 cells, while treatment with the control reagent cytosine arabinoside did not influence the expression of this gene
the dysregulation of miR (show MLXIP ELISA Kits)-206-CCND2 axis may contribute to the aggressive progression and poor prognosis of human gastric cancer.
miR (show MLXIP ELISA Kits)-26a regulated mouse hepatocyte proliferation by directly targeting the 3' untranslated regions of cyclin D2/cyclin E2 (show CCNE2 ELISA Kits).
NF-kappaB (show NFKB1 ELISA Kits)-miR (show MLXIP ELISA Kits)-195/497-Igf1r (show IGF1R ELISA Kits)/Insr (show INSR ELISA Kits)-Ccnd2/Ccne1 (show CCNE1 ELISA Kits) plays important roles in myogenesis.
Loss of N-myc (show MYCN ELISA Kits) significantly impairs the Sonic hedgehog (show SHH ELISA Kits) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2.
Activation of the ERK1/2 (show MAPK1/3 ELISA Kits) signalling pathway, increased phosphorylation of c-myc (show MYC ELISA Kits) and significantly increased expression of cyclin D2 protein, are demonstrated.
Hippocampus-dependent learning was not generally impaired in Ccnd2 knockout mice, but specifically functional aspects of maze learning were affected.
FGF2 signaling results in the phosphorylation of Erk1/2, and activation of c-Fos and c-Jun that lead to elevated cyclin D mRNA levels.
Islet ARNT (show ARNT ELISA Kits) increases in normal murine pregnancy and beta-cell ARNT (show ARNT ELISA Kits) is required for cyclinD2 induction and increased beta-cell proliferation in pregnancy.
Study reveals molecular insight into how the Ets (show ETS1 ELISA Kits) family transcription factor Pea3 (show ETV4 ELISA Kits) favors EMT (show ITK ELISA Kits) and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2, a new Pea3 (show ETV4 ELISA Kits) target gene.
results identify CCND2 as a new key regulator of terminal differentiation in muscle progenitor cells and open new possibilities for the treatment of many forms of muscle disorders characterized by impaired regeneration and loss of muscle mass.
Our data suggest that Smoothened signaling, acting through cyclin D2, is critical for the proper development and maturation of the neocortex.
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 (show PSEN1 ELISA Kits) genes via a STAT3 (show STAT3 ELISA Kits)-dependent pathway
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
, G1/S-specific cyclin-D2
, G1/S-specific cyclin D2
, vin-1 proto-oncogene