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The results do not support our hypothesis that common germline genetic variants in the CCND2 genes is associated with the risk of developing medulloblastoma.
miR (show MLXIP ELISA Kits)-198 inhibited HaCaT cell proliferation by directly targeting CCND2.
CCND2 was identified as a putative target gene for SMYD3 (show SMYD3 ELISA Kits) transcriptional regulation, through trimethylation of H4K20.Our results support a proto-oncogenic role for SMYD3 (show SMYD3 ELISA Kits) in prostate carcinogenesis, mainly due to its methyltransferase enzymatic activity.
Treatment of rSCC-61 and SCC (show CYP11A1 ELISA Kits)-61 with the DNA hypomethylating agent 5-aza-2'deoxycitidine increased CCND2 levels only in rSCC-61 cells, while treatment with the control reagent cytosine arabinoside did not influence the expression of this gene
the dysregulation of miR (show MLXIP ELISA Kits)-206-CCND2 axis may contribute to the aggressive progression and poor prognosis of human gastric cancer.
OY-TES-1 (show ACRBP ELISA Kits) downregulation in liver cancer cells promotes cell proliferation by upregulating CCND2 and CDCA3 (show CDCA3 ELISA Kits).
Cyclin D2 hypermethylation is associated with breast cancer.
SUMO modification of ATF3 (show ATF3 ELISA Kits) influences CCND1 (show CCND1 ELISA Kits)/2 activity and cellular proliferation of prostate cancer PC3 (show PCSK1 ELISA Kits) and DU145 cells and explains at least in part how ATF3 (show ATF3 ELISA Kits) functions to regulate cancer development.
Methylation changes were enriched in MSX1 (show MSX1 ELISA Kits), CCND2, and DAXX (show DAXX ELISA Kits) at specific loci within the hippocampus of patients with schizophrenia and bipolar disorder.
study establishes that a low frequency allele in CCND2 halves the risk of type 2 diabetes primarily through enhanced insulin (show INS ELISA Kits) secretion
Loss of N-myc (show MYCN ELISA Kits) significantly impairs the Sonic hedgehog (show SHH ELISA Kits) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2.
Activation of the ERK1/2 (show MAPK1/3 ELISA Kits) signalling pathway, increased phosphorylation of c-myc (show MYC ELISA Kits) and significantly increased expression of cyclin D2 protein, are demonstrated.
Hippocampus-dependent learning was not generally impaired in Ccnd2 knockout mice, but specifically functional aspects of maze learning were affected.
FGF2 signaling results in the phosphorylation of Erk1/2, and activation of c-Fos and c-Jun that lead to elevated cyclin D mRNA levels.
Islet ARNT (show ARNT ELISA Kits) increases in normal murine pregnancy and beta-cell ARNT (show ARNT ELISA Kits) is required for cyclinD2 induction and increased beta-cell proliferation in pregnancy.
Study reveals molecular insight into how the Ets (show ETS1 ELISA Kits) family transcription factor Pea3 (show ETV4 ELISA Kits) favors EMT (show ITK ELISA Kits) and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2, a new Pea3 (show ETV4 ELISA Kits) target gene.
results identify CCND2 as a new key regulator of terminal differentiation in muscle progenitor cells and open new possibilities for the treatment of many forms of muscle disorders characterized by impaired regeneration and loss of muscle mass.
Our data suggest that Smoothened signaling, acting through cyclin D2, is critical for the proper development and maturation of the neocortex.
This study demonistrated that irradiated wild type and cyclin D2 knockout mice displayed memory deficits one week after acquisition.
Cyclin D2 protein expression was increased in islets by day 7, suggesting it may be an early effector driving compensatory beta-cell proliferation in mice eating dietary fats.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
, G1/S-specific cyclin-D2
, G1/S-specific cyclin D2
, vin-1 proto-oncogene