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Browse our Cyclin D2 Proteins (CCND2)

Full name:
Cyclin D2 Proteins (CCND2)
On www.antibodies-online.com are 17 Cyclin D2 (CCND2) Proteins from 7 different suppliers available. Additionally we are shipping Cyclin D2 Antibodies (190) and Cyclin D2 Kits (55) and many more products for this protein. A total of 268 Cyclin D2 products are currently listed.
Synonyms:
2600016F06Rik, AI256817, BF642806, C86853, CCND2, cD2, KIAK0002, LOC100224096, si:ch211-240j22.2, Vin-1, Vin1, zgc:162280
list all proteins Gene Name GeneID UniProt
CCND2 894 P30279
CCND2 12444 P30280
CCND2 64033 Q04827

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Cyclin D2 Proteins (CCND2) by Origin

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Top referenced Cyclin D2 Proteins

  1. Human Cyclin D2 Protein expressed in Escherichia coli (E. coli) - ABIN667637 : Wang, Xie, Zhang, Zhang, An, Wang, Meng: Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition. in Cell structure and function 2008 (PubMed)
    Show all 2 references for ABIN667637

More Proteins for Cyclin D2 Interaction Partners

Human Cyclin D2 (CCND2) interaction partners

  1. this study shows that miR (show MLXIP Proteins)-124-3p may negatively regulate the transcription of the STAT3 (show STAT3 Proteins) by interfering with its 3'UTR, and the degradation of STAT3 (show STAT3 Proteins) affects its downstream expression of such as p-STAT3 (show STAT3 Proteins), CCND2 and MMP-2 (show MMP2 Proteins)

  2. these results highlight the impact of CCND2 3'UTR shortening on miRNA-dependent regulation of CCND2 in multiple myeloma.

  3. The results do not support our hypothesis that common germline genetic variants in the CCND2 genes is associated with the risk of developing medulloblastoma.

  4. miR (show MLXIP Proteins)-198 inhibited HaCaT cell proliferation by directly targeting CCND2.

  5. CCND2 was identified as a putative target gene for SMYD3 (show SMYD3 Proteins) transcriptional regulation, through trimethylation of H4K20.Our results support a proto-oncogenic role for SMYD3 (show SMYD3 Proteins) in prostate carcinogenesis, mainly due to its methyltransferase enzymatic activity.

  6. Treatment of rSCC-61 and SCC (show CYP11A1 Proteins)-61 with the DNA hypomethylating agent 5-aza-2'deoxycitidine increased CCND2 levels only in rSCC-61 cells, while treatment with the control reagent cytosine arabinoside did not influence the expression of this gene

  7. the dysregulation of miR (show MLXIP Proteins)-206-CCND2 axis may contribute to the aggressive progression and poor prognosis of human gastric cancer.

  8. OY-TES-1 (show ACRBP Proteins) downregulation in liver cancer cells promotes cell proliferation by upregulating CCND2 and CDCA3 (show CDCA3 Proteins).

  9. Cyclin D2 hypermethylation is associated with breast cancer.

  10. SUMO modification of ATF3 (show ATF3 Proteins) influences CCND1 (show CCND1 Proteins)/2 activity and cellular proliferation of prostate cancer PC3 (show PCSK1 Proteins) and DU145 cells and explains at least in part how ATF3 (show ATF3 Proteins) functions to regulate cancer development.

Mouse (Murine) Cyclin D2 (CCND2) interaction partners

  1. miR (show MLXIP Proteins)-26a regulated mouse hepatocyte proliferation by directly targeting the 3' untranslated regions of cyclin D2/cyclin E2 (show CCNE2 Proteins).

  2. NF-kappaB (show NFKB1 Proteins)-miR (show MLXIP Proteins)-195/497-Igf1r (show IGF1R Proteins)/Insr (show INSR Proteins)-Ccnd2/Ccne1 (show CCNE1 Proteins) plays important roles in myogenesis.

  3. Loss of N-myc (show MYCN Proteins) significantly impairs the Sonic hedgehog (show SHH Proteins) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2.

  4. Activation of the ERK1/2 signalling pathway, increased phosphorylation of c-myc (show MYC Proteins) and significantly increased expression of cyclin D2 protein, are demonstrated.

  5. Hippocampus-dependent learning was not generally impaired in Ccnd2 knockout mice, but specifically functional aspects of maze learning were affected.

  6. FGF2 signaling results in the phosphorylation of Erk1/2, and activation of c-Fos and c-Jun that lead to elevated cyclin D mRNA levels.

  7. Islet ARNT (show ARNT Proteins) increases in normal murine pregnancy and beta-cell ARNT (show ARNT Proteins) is required for cyclinD2 induction and increased beta-cell proliferation in pregnancy.

  8. Study reveals molecular insight into how the Ets (show ETS1 Proteins) family transcription factor Pea3 (show ETV4 Proteins) favors EMT (show ITK Proteins) and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2, a new Pea3 (show ETV4 Proteins) target gene.

  9. results identify CCND2 as a new key regulator of terminal differentiation in muscle progenitor cells and open new possibilities for the treatment of many forms of muscle disorders characterized by impaired regeneration and loss of muscle mass.

  10. Our data suggest that Smoothened signaling, acting through cyclin D2, is critical for the proper development and maturation of the neocortex.

Cyclin D2 (CCND2) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.

Alternative names and synonyms associated with Cyclin D2 (CCND2)

  • cyclin D2, b (ccnd2b)
  • cyclin D2 (ccnd2-b)
  • cyclin D2 (CCND2)
  • cyclin D2 (ccnd2)
  • G1/S-specific cyclin-D2 (ccnd2)
  • cyclin D2, a (ccnd2a)
  • cyclin D2 (LOC100224096)
  • cyclin D1 (CCND1)
  • cyclin D2 (Ccnd2)
  • cyclin D2 (ccnd2-a)
  • 2600016F06Rik protein
  • AI256817 protein
  • BF642806 protein
  • C86853 protein
  • CCND2 protein
  • cD2 protein
  • KIAK0002 protein
  • LOC100224096 protein
  • si:ch211-240j22.2 protein
  • Vin-1 protein
  • Vin1 protein
  • zgc:162280 protein

Protein level used designations for Cyclin D2 Proteins (CCND2)

cyclin D2 , G1/S-specific cyclin-D2 , ccnd2 , G1/S-specific cyclin D2 , vin-1 proto-oncogene

GENE ID SPECIES
565038 Danio rerio
734882 Xenopus laevis
747123 Pan troglodytes
779063 Xenopus laevis
100038071 Xenopus (Silurana) tropicalis
100195486 Salmo salar
799608 Danio rerio
100224096 Taeniopygia guttata
100009036 Oryctolagus cuniculus
894 Homo sapiens
12444 Mus musculus
64033 Rattus norvegicus
100730596 Cavia porcellus
397162 Sus scrofa
615414 Bos taurus
374047 Gallus gallus
611782 Canis lupus familiaris
100147799 Ovis aries
373667 Xenopus laevis
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