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Human Cyclin D2 Protein expressed in Escherichia coli (E. coli) - ABIN667637
Wang, Xie, Zhang, Zhang, An, Wang, Meng: Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition. in Cell structure and function 2008
Show all 2 references for ABIN667637
the phosphorylation levels of ErbB2 (show ERBB2 Proteins), ErbB3 (show ERBB3 Proteins) and Akt (show AKT1 Proteins) and the protein levels of cyclin D1 (show CCND1 Proteins) were decreased by lapatinib treatment of HSC3, HSC4 and Ca9 (show CA9 Proteins)-22 cells
miR (show MLXIP Proteins)-155 overexpression plays a promoting role in the proliferative, migratory and invasive behavior of OSCC cells. Its effects on OSCC are possibly associated with its regulation of the BCL6 (show BCL6 Proteins)/cyclin D2 axis.
Bioinformatics analysis further revealed cyclin D2 (CCND2) and AKT3 (show AKT3 Proteins), putative tumor promoters, as potential targets of miR610. Data from reporter assays showed that miR610 directly binds to the 3'untranslated
this study shows that miR (show MLXIP Proteins)-124-3p may negatively regulate the transcription of the STAT3 (show STAT3 Proteins) by interfering with its 3'UTR, and the degradation of STAT3 (show STAT3 Proteins) affects its downstream expression of such as p-STAT3 (show STAT3 Proteins), CCND2 and MMP-2 (show MMP2 Proteins)
these results highlight the impact of CCND2 3'UTR shortening on miRNA-dependent regulation of CCND2 in multiple myeloma.
The results do not support our hypothesis that common germline genetic variants in the CCND2 genes is associated with the risk of developing medulloblastoma.
miR (show MLXIP Proteins)-198 inhibited HaCaT cell proliferation by directly targeting CCND2.
CCND2 was identified as a putative target gene for SMYD3 (show SMYD3 Proteins) transcriptional regulation, through trimethylation of H4K20.Our results support a proto-oncogenic role for SMYD3 (show SMYD3 Proteins) in prostate carcinogenesis, mainly due to its methyltransferase enzymatic activity.
Treatment of rSCC-61 and SCC (show CYP11A1 Proteins)-61 with the DNA hypomethylating agent 5-aza-2'deoxycitidine increased CCND2 levels only in rSCC-61 cells, while treatment with the control reagent cytosine arabinoside did not influence the expression of this gene
the dysregulation of miR (show MLXIP Proteins)-206-CCND2 axis may contribute to the aggressive progression and poor prognosis of human gastric cancer.
miR (show MLXIP Proteins)-26a regulated mouse hepatocyte proliferation by directly targeting the 3' untranslated regions of cyclin D2/cyclin E2 (show CCNE2 Proteins).
NF-kappaB (show NFKB1 Proteins)-miR (show MLXIP Proteins)-195/497-Igf1r (show IGF1R Proteins)/Insr (show INSR Proteins)-Ccnd2/Ccne1 (show CCNE1 Proteins) plays important roles in myogenesis.
Loss of N-myc (show MYCN Proteins) significantly impairs the Sonic hedgehog (show SHH Proteins) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2.
Activation of the ERK1/2 signalling pathway, increased phosphorylation of c-myc (show MYC Proteins) and significantly increased expression of cyclin D2 protein, are demonstrated.
Hippocampus-dependent learning was not generally impaired in Ccnd2 knockout mice, but specifically functional aspects of maze learning were affected.
FGF2 signaling results in the phosphorylation of Erk1/2, and activation of c-Fos and c-Jun that lead to elevated cyclin D mRNA levels.
Islet ARNT (show ARNT Proteins) increases in normal murine pregnancy and beta-cell ARNT (show ARNT Proteins) is required for cyclinD2 induction and increased beta-cell proliferation in pregnancy.
Study reveals molecular insight into how the Ets (show ETS1 Proteins) family transcription factor Pea3 (show ETV4 Proteins) favors EMT (show ITK Proteins) and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2, a new Pea3 (show ETV4 Proteins) target gene.
results identify CCND2 as a new key regulator of terminal differentiation in muscle progenitor cells and open new possibilities for the treatment of many forms of muscle disorders characterized by impaired regeneration and loss of muscle mass.
Our data suggest that Smoothened signaling, acting through cyclin D2, is critical for the proper development and maturation of the neocortex.
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 (show PSEN1 Proteins) genes via a STAT3 (show STAT3 Proteins)-dependent pathway
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
, G1/S-specific cyclin-D2
, G1/S-specific cyclin D2
, vin-1 proto-oncogene