Browse our Cyclin D2 Proteins (CCND2)

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Cyclin D2 Proteins (CCND2)
On are 18 Cyclin D2 (CCND2) Proteins from 8 different suppliers available. Additionally we are shipping Cyclin D2 Antibodies (190) and Cyclin D2 Kits (41) and many more products for this protein. A total of 255 Cyclin D2 products are currently listed.
2600016F06Rik, AI256817, BF642806, C86853, CCND2, cD2, KIAK0002, LOC100224096, si:ch211-240j22.2, Vin-1, Vin1, zgc:162280
list all proteins Gene Name GeneID UniProt
CCND2 894 P30279
CCND2 12444 P30280
CCND2 64033 Q04827

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Cyclin D2 Proteins (CCND2) by Origin

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Top referenced Cyclin D2 Proteins

  1. Human Cyclin D2 Protein expressed in Escherichia coli (E. coli) - ABIN667637 : Wang, Xie, Zhang, Zhang, An, Wang, Meng: Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition. in Cell structure and function 2008 (PubMed)
    Show all 2 references for 667637

More Proteins for Cyclin D2 Interaction Partners

Human Cyclin D2 (CCND2) interaction partners

  1. data suggested that loss of CCND2 expression is closely associated with the promoter aberrant methylation

  2. MiR (show MLXIP Proteins)-497 significantly suppressed cell proliferation by arresting the cell cycle through the CCND2 protein.

  3. cyclin D2 acts as regulator of cell cycle (show C13orf15 Proteins) proteins affecting SAMHD1 (show SAMHD1 Proteins)-mediated HIV-1 restriction in non-proliferating macrophages.

  4. CCND2-AS1 (show PTGDR Proteins) promotes glioma cells proliferation and growth in a process that involves Wnt (show WNT2 Proteins) and beta-catenin (show CTNNB1 Proteins)

  5. CCND1 (show CCND1 Proteins) is downregulated, whereas CCND2 is not, following ionizing radiation (IR) . Both CCND1 (show CCND1 Proteins)- and CCND2-expressing MM cells arrested in S/G2 (show STRN3 Proteins)/M, and did not differ in other cell-cycle proteins or sensitivity to IR.Differential expression of D-cyclin (show PCNA Proteins) does not appear to affect cell-cycle response to IR, and is unlikely to underlie differential sensitivity to DNA damage.

  6. the phosphorylation levels of ErbB2 (show ERBB2 Proteins), ErbB3 (show ERBB3 Proteins) and Akt (show AKT1 Proteins) and the protein levels of cyclin D1 (show CCND1 Proteins) were decreased by lapatinib treatment of HSC3, HSC4 and Ca9 (show CA9 Proteins)-22 cells

  7. miR (show MLXIP Proteins)-155 overexpression plays a promoting role in the proliferative, migratory and invasive behavior of OSCC cells. Its effects on OSCC are possibly associated with its regulation of the BCL6 (show BCL6 Proteins)/cyclin D2 axis.

  8. Bioinformatics analysis further revealed cyclin D2 (CCND2) and AKT3 (show AKT3 Proteins), putative tumor promoters, as potential targets of miR610. Data from reporter assays showed that miR610 directly binds to the 3'untranslated

  9. this study shows that miR (show MLXIP Proteins)-124-3p may negatively regulate the transcription of the STAT3 (show STAT3 Proteins) by interfering with its 3'UTR, and the degradation of STAT3 (show STAT3 Proteins) affects its downstream expression of such as p-STAT3 (show STAT3 Proteins), CCND2 and MMP-2 (show MMP2 Proteins)

  10. these results highlight the impact of CCND2 3'UTR shortening on miRNA-dependent regulation of CCND2 in multiple myeloma.

Mouse (Murine) Cyclin D2 (CCND2) interaction partners

  1. cyclin D2 acts as regulator of cell cycle (show C13orf15 Proteins) proteins affecting SAMHD1 (show SAMHD1 Proteins)-mediated HIV-1 restriction in non-proliferating macrophages.

  2. Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta (show PRKCZ Proteins)) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (show INS Proteins) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin (show FRAP1 Proteins) protein) and Ccnd2 (cyclin-D2).

  3. miR (show MLXIP Proteins)-26a regulated mouse hepatocyte proliferation by directly targeting the 3' untranslated regions of cyclin D2/cyclin E2 (show CCNE2 Proteins).

  4. NF-kappaB (show NFKB1 Proteins)-miR (show MLXIP Proteins)-195/497-Igf1r (show IGF1R Proteins)/Insr (show INSR Proteins)-Ccnd2/Ccne1 (show CCNE1 Proteins) plays important roles in myogenesis.

  5. Loss of N-myc (show MYCN Proteins) significantly impairs the Sonic hedgehog (show SHH Proteins) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2.

  6. Activation of the ERK1/2 signalling pathway, increased phosphorylation of c-myc (show MYC Proteins) and significantly increased expression of cyclin D2 protein, are demonstrated.

  7. Hippocampus-dependent learning was not generally impaired in Ccnd2 knockout mice, but specifically functional aspects of maze learning were affected.

  8. FGF2 signaling results in the phosphorylation of Erk1/2, and activation of c-Fos and c-Jun that lead to elevated cyclin D mRNA levels.

  9. Islet ARNT (show ARNT Proteins) increases in normal murine pregnancy and beta-cell ARNT (show ARNT Proteins) is required for cyclinD2 induction and increased beta-cell proliferation in pregnancy.

  10. Study reveals molecular insight into how the Ets (show ETS1 Proteins) family transcription factor Pea3 (show ETV4 Proteins) favors EMT (show ITK Proteins) and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2, a new Pea3 (show ETV4 Proteins) target gene.

Pig (Porcine) Cyclin D2 (CCND2) interaction partners

  1. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 (show PSEN1 Proteins) genes via a STAT3 (show STAT3 Proteins)-dependent pathway

Cyclin D2 (CCND2) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.

Alternative names and synonyms associated with Cyclin D2 (CCND2)

  • cyclin D2, b (ccnd2b)
  • cyclin D2 (ccnd2-b)
  • cyclin D2 (CCND2)
  • cyclin D2 (ccnd2)
  • G1/S-specific cyclin-D2 (ccnd2)
  • cyclin D2, a (ccnd2a)
  • cyclin D2 (LOC100224096)
  • cyclin D1 (CCND1)
  • cyclin D2 (Ccnd2)
  • cyclin D2 (ccnd2-a)
  • 2600016F06Rik protein
  • AI256817 protein
  • BF642806 protein
  • C86853 protein
  • CCND2 protein
  • cD2 protein
  • KIAK0002 protein
  • LOC100224096 protein
  • si:ch211-240j22.2 protein
  • Vin-1 protein
  • Vin1 protein
  • zgc:162280 protein

Protein level used designations for Cyclin D2 Proteins (CCND2)

cyclin D2 , G1/S-specific cyclin-D2 , ccnd2 , G1/S-specific cyclin D2 , vin-1 proto-oncogene

565038 Danio rerio
734882 Xenopus laevis
747123 Pan troglodytes
779063 Xenopus laevis
100038071 Xenopus (Silurana) tropicalis
100195486 Salmo salar
799608 Danio rerio
100224096 Taeniopygia guttata
100009036 Oryctolagus cuniculus
894 Homo sapiens
12444 Mus musculus
64033 Rattus norvegicus
100730596 Cavia porcellus
397162 Sus scrofa
615414 Bos taurus
374047 Gallus gallus
611782 Canis lupus familiaris
100147799 Ovis aries
373667 Xenopus laevis
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