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cyclin-D1 (show CCND1 Proteins) and cyclin-D3 within human islet cells varies according to the status of the pancreas donor
The CDK6 (show CDK6 Proteins)-cyclin D3 pair play a fundamental role in controlling CDK2 (show CDK2 Proteins)-dependent SAMHD1 (show SAMHD1 Proteins) phosphorylation and the dNTP pool in primary macrophages.
Two recurrent fusion genes associated with the 12q locus, LRP1 (show LRP1 Proteins)-SNRNP25 (show SNRNP25 Proteins) and KCNMB4 (show KCNMB4 Proteins)-CCND3, were by RT-PCR, Sanger sequencing and FISH, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas.
G1 arrest induced by SB265610 occurred at concentrations lacking CXCR2 (show CXCR2 Proteins) selectivity and revealed cyclin-dependent kinase 2 (CDK2 (show CDK2 Proteins)) (Thr160) hypophosphorylation, cyclin D3 gene down-regulation, and p21 (show CDKN1A Proteins) post-translational induction
sLZIP regulates the transcription of cyclin D3 by binding directly to the AP-1 (show FOSB Proteins) region in the cyclin D3 promoter.
combined expression of miR (show MLXIP Proteins)-138 and its direct target CCND3 may be correlated with significant characteristics of hepatocellular carcinoma
Namely the amplification of the expression of the PLCB1a (show PLCB1 Proteins), but not of PLCB1b (show PLCB1 Proteins), is able to maintain high levels of expression of cyclin D3 even after treatment with kinamycin F
cell cycle related proteins PCNA (show PCNA Proteins), Ki67 (show MKI67 Proteins), cyclin D3, p27 (show PAK2 Proteins) and p57 (show CDKN1C Proteins) were expressed in both normal and diabetic human term placentas.
Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 (show IGF2BP3 Proteins) nuclear localization.
two cell cycle-related molecules, cyclin D3 and E2F3, were identified as the direct miR (show MLXIP Proteins)-503 targets.
The swine UCHL3 (show Uchl3 Proteins), RIT1 (show RIT1 Proteins) and CCND3 genes were found to be differentially expressed in tissues including small intestine, large intestine, liver, muscle, fat, lung, spleen and kidney.
we suggest that proper regional decidualization and polyploidy development requires FoxM1 (show FOXM1 Proteins) signaling downstream of Hoxa10 (show HOXA10 Proteins) and cyclin D3.
Cyclin D3 protein that drives immature T cell proliferation is essential for transformation of Atm (show ATM Proteins)-deficient thymocytes
DYRK1A (show DYRK1A Proteins) has a role in lymphopoiesis; Cyclin D3 protein stability is negatively regulated during exit from the proliferative phases of B and T cell development
inactivation of Ccnd3 leads to increased frequencies of lymphocytes with biallelic expression of IgH or TCRbeta genes.
FGF2 signaling results in the phosphorylation of Erk1/2, and activation of c-Fos and c-Jun that lead to elevated cyclin D mRNA levels.
Results indicate that cyclin D3 plays a cell-autonomous and nonredundant function in regulating the dynamic balance between proliferation, differentiation, and self-renewal that normally establishes an appropriate pool size of adult satellite cells.
Investigated the expression of GABA and GABPR in the early-pregnancy mouse uterus. Cyclin D3 was measured in cultured stromal cells artificially induced to undergo decidualization, by GABA and a GABA A-type receptor agonist or antagonist.
Subnuclear compartmentalization enables cyclin D3 to drive cell cycle progression and repress V gene accessibility, thereby ensuring coordination of proliferation with immunoglobulin recombination.
cyclin D3 expression influences a host of genes involved in decidualization and can improve decidualization in Hoxa-10 (show HOXA10 Proteins)(-/-) mice.
CCND3 gene product cyclin D3 regulates the number of cell divisions that erythroid precursors undergo during terminal differentiation
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.
, G1/S-specific cyclin-D3
, D3-type cyclin
, G1/S-specific cyclin D3