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Ad-cycE can target cyclin E overexpression in cancer cells and repress tumor growth in syngeneic mouse models.
ovary tumors with elevated CCNE1 expression may be staged for Cdk2 (show CDK2 ELISA Kits)-targeted therapy
our findings identify a novel mechanism of cyclin E-mediated Mcl-1 (show MCL1 ELISA Kits) regulation in human cancer
miR (show MLXIP ELISA Kits)-15b might be involved in termination of osteoblastic cells proliferation by arresting them at G0/G1 phase through direct targeting cyclin E1.
A significant correlation between cyclin E1 amplification and deletions at a number of the genomic loci in breast cancer.
These results indicate cyclin E1 is downregulated by both miR (show MLXIP ELISA Kits)-497 and miR (show MLXIP ELISA Kits)-34a, which synergistically retard the growth of human lung cancer cells.
MicroRNA-30c-2-3p negatively regulates NF-kappaB (show NFKB1 ELISA Kits) signaling and cell cycle progression through downregulation of TRADD (show TRADD ELISA Kits) and CCNE1 in breast cancer.
Both fenhexamid and cyprodinil may increase cancer cell proliferation by stimulating the protein expressions of cyclin D1 (show CCND1 ELISA Kits) and cyclin E.
Results show that miR-16 (show GDE1 ELISA Kits) and HuR (show ELAVL1 ELISA Kits) co-regulate the cyclin E1 mRNA without influencing each other's binding or expression. miR-16 (show GDE1 ELISA Kits) regulation predominates, blocking upregulation of cyclin E1 by HuR (show ELAVL1 ELISA Kits).
Expression of Notch1 (show NOTCH1 ELISA Kits), -2, and -3, CDK2 (show CDK2 ELISA Kits), and CCNE1 was significantly decreased by upregulation of ALDH1A1 (show ALDH1A1 ELISA Kits) in A549 cells, but increased by its interruption in A549s cells.
Myb (show MYB ELISA Kits) regulates Cyclin E1 expression in normal gastrointestinal tract epithelial cells and is required during intestinal tumorigenesis
These results highlight a new role for E-type cyclins (Ccne1 and Ccne2 (show CCNE2 ELISA Kits)) as important regulators of male meiosis.
Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 (show CDK2 ELISA Kits) in hepatocytes inhibits DNA replication and liver regeneration in mice.
Superoxide dismutase (show SOD1 ELISA Kits) induces G1-phase cell cycle arrest by down-regulated expression of Cdk-2 (show CDK2 ELISA Kits) and cyclin-E in sarcoma tumor cells.
Ablation of cyclin E led to a decreased number of synapses, reduced number and volume of dendritic spines, and resulted in impaired synaptic plasticity and memory formation.
Data show that gastric cancer markers MUC2 (show MUC2 ELISA Kits), and oncogenes c-myc (show MYC ELISA Kits), cyclin E1 were expressed in the gastric carcinoma cell line 3I (MGCC3I).
our fi ndings reveal a direct link between cyclin E and HIF-1 (show HIF1A ELISA Kits) activities in mammary epithelial cells and implicate HIF-1 (show HIF1A ELISA Kits) as a mediator of proliferation-independent phenotypes associated with high cyclin E expression in some human breast cancers.
Report presents the first detailed analysis of cyclin E expression in postmitotic neurons during development and in the adult mouse brain
Results show that deregulation of cyclin E expression contribute to infertility, due to inability of the spermatogonial cells to start the mitotic cycles prior to entering meiosis.
Depletion of cyclin E promoted apoptosis of breast cancer cells and blocked proliferation and transformation.
miR (show MYLIP ELISA Kits)-15/16 and CPEB co-regulate cyclin E1 mRNA.
cyclin E is dynamically and highly conjugated to SUMO2 (show SUMO2 ELISA Kits)/3 on chromatin, independently of Cdk2 (show CDK2 ELISA Kits) activity and origin activation.
These results show that cyclin E destruction at the midblastula transition requires both phosphorylation and nuclear import, as well as proteasomal activity.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 ELISA Kits), wee1 (show WEE1 ELISA Kits), p21 (show CDKN1A ELISA Kits), PCNA (show PCNA ELISA Kits) and cdk2 (show CDK2 ELISA Kits), but only weakly influences cyclin B1 (show CCNB1 ELISA Kits), cyclin B2 (show CCNB2 ELISA Kits) and cyclin E1 expression.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
, G1/S-specific cyclin-E1
, G1/S-specific cyclin-E1-like
, g1/S-specific cyclin-E1-like
, cyclin Es
, cyclin Et
, cyclin E
, G1/S-specific cyclin-E2
, G1/S-specific cyclin-E3
, cyclin E3