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inhibition of PDK4 (show PDK4 Proteins) activity in Hepatocellular carcinoma cells increased cyclin E1, cyclin A2 (show CCNA2 Proteins), and E2F1 (show E2F1 Proteins) proteins.
The present study evaluates the prognostic role of the p53 (show TP53 Proteins), Bax (show BAX Proteins), Bcl-2 (show BCL2 Proteins) and cyclin E immunoexpression in colon cancer.
High CCNE1 amplification and expression is associated with breast cancer.
CCNE1/REL gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis.
These results indicate that miR (show MLXIP Proteins)-25 has anti-apoptosis roles in AGS (show JAG1 Proteins) cells, possibly via inhibiting FBXW7 (show FBXW7 Proteins) and thus promoting oncogenes, such as CCNE1 and MYC (show MYC Proteins).
Cyclin E-driven OvCa cells appeared addicted to glucose metabolism via TCA. Combined CDKi (show CDKN1C Proteins) with modalities targeting TCA, like SDHA (show SDHA Proteins) inhibition showed promising effects for this genotype. Combined blockade of CDK (show CDK4 Proteins) and SDH, both genetically and pharmaceutically, showed synergy and resulted in inhibited proliferation, migration, invasion and migration in A2780 cells
Over-expression of CCNE1 is associated with non-small cell lung cancer.
The BCL2 (show BCL2 Proteins), MCM7 (show MCM7 Proteins), and CCNE1 genes might play distinctive roles in cisplatin resistance in bladder cancer.
High levels of cyclin E are a predicator of poor prognosis among patients with gastrointestinal cancer. [meta-analysis]
Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21 (show CDKN1A Proteins), p27 (show PAK2 Proteins)-cyclin E,A/Cdk2 (show CDK2 Proteins) pathway.
Spermatocytes lacking cyclin E2 (show CCNE2 Proteins) and one E1 allele (E1+/-E2-/-) displayed a high rate of telomere abnormalities but can progress to pachytene and diplotene stages.
NF-kappaB (show NFKB1 Proteins)-miR (show MLXIP Proteins)-195/497-Igf1r (show IGF1R Proteins)/Insr (show INSR Proteins)-Ccnd2 (show CCND2 Proteins)/Ccne1 plays important roles in myogenesis.
Myb (show MYB Proteins) regulates Cyclin E1 expression in normal gastrointestinal tract epithelial cells and is required during intestinal tumorigenesis
These results highlight a new role for E-type cyclins (Ccne1 and Ccne2 (show CCNE2 Proteins)) as important regulators of male meiosis.
Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 (show CDK2 Proteins) in hepatocytes inhibits DNA replication and liver regeneration in mice.
Superoxide dismutase (show SOD1 Proteins) induces G1-phase cell cycle arrest by down-regulated expression of Cdk-2 (show CDK2 Proteins) and cyclin-E in sarcoma tumor cells.
Ablation of cyclin E led to a decreased number of synapses, reduced number and volume of dendritic spines, and resulted in impaired synaptic plasticity and memory formation.
Data show that gastric cancer markers MUC2 (show MUC2 Proteins), and oncogenes c-myc (show MYC Proteins), cyclin E1 were expressed in the gastric carcinoma cell line 3I (MGCC3I).
our fi ndings reveal a direct link between cyclin E and HIF-1 (show HIF1A Proteins) activities in mammary epithelial cells and implicate HIF-1 (show HIF1A Proteins) as a mediator of proliferation-independent phenotypes associated with high cyclin E expression in some human breast cancers.
miR (show MYLIP Proteins)-15/16 and CPEB co-regulate cyclin E1 mRNA.
cyclin E is dynamically and highly conjugated to SUMO2 (show SUMO2 Proteins)/3 on chromatin, independently of Cdk2 (show CDK2 Proteins) activity and origin activation.
These results show that cyclin E destruction at the midblastula transition requires both phosphorylation and nuclear import, as well as proteasomal activity.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA (show PCNA Proteins) and cdk2 (show CDK2 Proteins), but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 expression.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
, G1/S-specific cyclin-E1
, G1/S-specific cyclin-E1-like
, g1/S-specific cyclin-E1-like
, cyclin Es
, cyclin Et
, cyclin E
, G1/S-specific cyclin-E2
, G1/S-specific cyclin-E3
, cyclin E3