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Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21 (show CDKN1A Proteins), p27 (show PAK2 Proteins)-cyclin E,A/Cdk2 (show CDK2 Proteins) pathway.
The effects of CCNE1 knockdown were dependent on the CCNE1 expression status.
Data show that melanoma antigen, family C, 2 protein (MAGE-C2) binds with RING-box protein 1 (Rbx1) and Cullin 1, and regulates cyclin E stability in melanoma cells.
The findings suggest that the role of cyclin E and tumor specific low molecular weight isoforms as mediators of tumorigenesis is in part dependent on p53 (show TP53 Proteins) context.
Ad-cycE can target cyclin E overexpression in cancer cells and repress tumor growth in syngeneic mouse models.
ovary tumors with elevated CCNE1 expression may be staged for Cdk2 (show CDK2 Proteins)-targeted therapy
our findings identify a novel mechanism of cyclin E-mediated Mcl-1 (show MCL1 Proteins) regulation in human cancer
miR (show MLXIP Proteins)-15b might be involved in termination of osteoblastic cells proliferation by arresting them at G0/G1 phase through direct targeting cyclin E1.
A significant correlation between cyclin E1 amplification and deletions at a number of the genomic loci in breast cancer.
These results indicate cyclin E1 is downregulated by both miR (show MLXIP Proteins)-497 and miR (show MLXIP Proteins)-34a, which synergistically retard the growth of human lung cancer cells.
NF-kappaB (show NFKB1 Proteins)-miR (show MLXIP Proteins)-195/497-Igf1r (show IGF1R Proteins)/Insr (show INSR Proteins)-Ccnd2 (show CCND2 Proteins)/Ccne1 plays important roles in myogenesis.
Myb (show MYB Proteins) regulates Cyclin E1 expression in normal gastrointestinal tract epithelial cells and is required during intestinal tumorigenesis
These results highlight a new role for E-type cyclins (Ccne1 and Ccne2 (show CCNE2 Proteins)) as important regulators of male meiosis.
Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 (show CDK2 Proteins) in hepatocytes inhibits DNA replication and liver regeneration in mice.
Superoxide dismutase (show SOD1 Proteins) induces G1-phase cell cycle arrest by down-regulated expression of Cdk-2 (show CDK2 Proteins) and cyclin-E in sarcoma tumor cells.
Ablation of cyclin E led to a decreased number of synapses, reduced number and volume of dendritic spines, and resulted in impaired synaptic plasticity and memory formation.
Data show that gastric cancer markers MUC2 (show MUC2 Proteins), and oncogenes c-myc (show MYC Proteins), cyclin E1 were expressed in the gastric carcinoma cell line 3I (MGCC3I).
our fi ndings reveal a direct link between cyclin E and HIF-1 (show HIF1A Proteins) activities in mammary epithelial cells and implicate HIF-1 (show HIF1A Proteins) as a mediator of proliferation-independent phenotypes associated with high cyclin E expression in some human breast cancers.
Report presents the first detailed analysis of cyclin E expression in postmitotic neurons during development and in the adult mouse brain
Results show that deregulation of cyclin E expression contribute to infertility, due to inability of the spermatogonial cells to start the mitotic cycles prior to entering meiosis.
miR (show MYLIP Proteins)-15/16 and CPEB co-regulate cyclin E1 mRNA.
cyclin E is dynamically and highly conjugated to SUMO2 (show SUMO2 Proteins)/3 on chromatin, independently of Cdk2 (show CDK2 Proteins) activity and origin activation.
These results show that cyclin E destruction at the midblastula transition requires both phosphorylation and nuclear import, as well as proteasomal activity.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA (show PCNA Proteins) and cdk2 (show CDK2 Proteins), but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 expression.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
, G1/S-specific cyclin-E1
, G1/S-specific cyclin-E1-like
, g1/S-specific cyclin-E1-like
, cyclin Es
, cyclin Et
, cyclin E
, G1/S-specific cyclin-E2
, G1/S-specific cyclin-E3
, cyclin E3