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Browse our FOXO3 Proteins (FOXO3)

Full name:
Forkhead Box O3 Proteins (FOXO3)
On www.antibodies-online.com are 8 Forkhead Box O3 (FOXO3) Proteins from 5 different suppliers available. Additionally we are shipping FOXO3 Antibodies (303) and FOXO3 Kits (30) and many more products for this protein. A total of 354 FOXO3 products are currently listed.
Synonyms:
1110048B16Rik, 2010203A17Rik, AF6q21, C76856, Fkhr2, Fkhrl1, FKHRL1P2, foxO, FOXO-3, FOXO2, foxO3, FoxO3A, wu:fb50g02, wu:fi33f07, xfoxo3, zgc:92176
list all proteins Gene Name GeneID UniProt
FOXO3 2309 O43524
FOXO3 56484 Q9WVH4
Rat FOXO3 FOXO3 294515  

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FOXO3 Proteins (FOXO3) by Origin

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Top referenced FOXO3 Proteins

  1. Human FOXO3 Protein expressed in Human - ABIN2721367 : Nott, Cheng, Gao, Lin, Gjoneska, Ko, Minhas, Zamudio, Meng, Zhang, Jin, Tsai: Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. in Nature neuroscience 2016 (PubMed)

  2. Human FOXO3 Protein expressed in Wheat germ - ABIN1354383 : Lützner, Kalbacher, Krones-Herzig, Rösl: FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop. in PLoS ONE 2012 (PubMed)

More Proteins for FOXO3 Interaction Partners

Zebrafish Forkhead Box O3 (FOXO3) interaction partners

  1. This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.

Human Forkhead Box O3 (FOXO3) interaction partners

  1. MCT1 (show CMA1 Proteins) expression associates with the SCC (show CYP11A1 Proteins) type and metastatic behavior of AC, whereas MCT4 (show SLC16A4 Proteins) expression concomitantly increases from in situ SCC (show CYP11A1 Proteins) to invasive SCC (show CYP11A1 Proteins) and is significantly associated with the AC type. Consistently, FOXM1 (show FOXM1 Proteins) expression is statistically associated with MCT1 (show CMA1 Proteins) positivity in SCC (show CYP11A1 Proteins), whereas the expression of FOXO3a, a FOXM1 (show FOXM1 Proteins) functional antagonist, is linked to MCT1 (show CMA1 Proteins) negativity

  2. SUN inhibits TNBC MDA-MB231 cell proliferation through activation of FOXO3a expression

  3. Results suggest that miR-155 down-regulates polymerase delta by targeting the transcription factor FOXO3a, thereby inhibiting the transcription of the four polymerase delta subunits, resulting in an increased susceptibility to mutation by suppressing a high-fidelity polymerase and favoring error prone translesion synthesis.

  4. FOXO3 is more active than FOXO1 (show FOXO1 Proteins) in primitive hematopoietic stem cells; the upstream regulators other than AKT (show AKT1 Proteins), such as SIRT1 (show SIRT1 Proteins), maintain nuclear FOXO localization and activity in hematopoietic stem cells.

  5. This work thus demonstrates that S-574 phosphorylation generates a specifically apoptotic form of FOXO3 with decreased transcriptional activity for other well-described FOXO3 functions.

  6. FOXO3a directly interacts with the Par-4 (show PAWR Proteins) promoter and activates and initiates caspase (show CASP3 Proteins)-mediated cell death upon Withaferin-A treatment.

  7. Stimulation with H2O2 decreased the phosphorylation of Akt (show AKT1 Proteins) and FoxO3a, and induced nuclear localization of FoxO3a and apoptosis of H9c2 cells. These effects of H2O2 were abrogated by pretreatment with FGF-2 (show FGF2 Proteins)

  8. Overexpression of FOXO3A is associated with breast cancer.

  9. Our findings indicate that FOXO3a is a significant factor in EGFR (show EGFR Proteins) mutation-independent gefitinib resistance and the stemness of lung cancer, and suggest that targeting the NF-kappaB (show NFKB1 Proteins)/miR (show MLXIP Proteins)-155/FOXO3a pathway has potential therapeutic value in lung cancer with the acquisition of resistance to EGFR (show EGFR Proteins)-TKIs.

  10. FOXO3a may play an important role in the intestinal inflammation of patients with UC.

Mouse (Murine) Forkhead Box O3 (FOXO3) interaction partners

  1. Iron-induced skeletal muscle atrophy is suggested to involve the E3 ubiquitin ligase (show MUL1 Proteins) mediated by the reduction of Akt (show AKT1 Proteins)-FOXO3a signaling by oxidative stress.

  2. Vesicular stomatitis virus (VSV) infection induced significant up-regulation of miR (show MLXIP Proteins)-223 in murine macrophages. miR (show MLXIP Proteins)-223 directly targets FOXO3 to regulate the type I IFN production.

  3. These findings demonstrate that melatonin attenuates cisplatin-induced follicle loss by preventing the phosphorylation of PTEN/AKT (show AKT1 Proteins)/FOXO3a pathway members; thus, melatonin is a potential therapeutic agent for ovarian protection and fertility preservation during chemotherapy in female cancer patients.

  4. This work thus demonstrates that S-574 phosphorylation generates a specifically apoptotic form of FOXO3 with decreased transcriptional activity for other well-described FOXO3 functions.

  5. SIRT6 (show SIRT6 Proteins) up-regulates AMP (show TMPRSS5 Proteins)/ATP and then activates the AMPK (show PRKAA1 Proteins)-FoxO3alpha axis and further initiates the downstream antioxidant-encoding gene expression, thereby decreasing cellular levels of oxidative stress, and mediating cardioprotection in ischemic heart

  6. Kit ligand (show KITLG Proteins) regulates the subcellular localization of FOXO3 in the neonatal mouse ovary.

  7. These data suggest a role for FoxO3a in the maintenance of genome integrity in response to DNA damage that is mediated by H2AX via yet unknown mechanisms.

  8. mice. In vitro assays revealed enhanced survival capacity of Myc (show MYC Proteins)-driven cells lacking FoxO3, but no change in cell cycling was detected

  9. Results point to an antioxidant defense mechanism presented by Sirt3 (show SIRT3 Proteins) through the activation of Foxo3a, in microglia

  10. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 (show CDK2 Proteins).

Pig (Porcine) Forkhead Box O3 (FOXO3) interaction partners

  1. These results indicate that myostatin (show MSTN Proteins) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (show NR3C1 Proteins) binding to its promoter.

  2. In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)

  3. PTEN, FOXO3A and PKB (show AKT1 Proteins) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

  4. Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.

  5. FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea

Cow (Bovine) Forkhead Box O3 (FOXO3) interaction partners

  1. NO/protein kinase (show CDK7 Proteins) G (PKG (show PRKG1 Proteins))-dependent downregulation of PGC-1 alpha and the ROS (show ROS1 Proteins) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 Proteins) signaling pathway and subsequent inactivation of transcription factor Foxo3a.

  2. FOXO is a key regulator of ROS (show ROS1 Proteins)-induced apoptosis in mammalian cells.

FOXO3 Protein Profile

Protein Summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.

Alternative names and synonyms associated with FOXO3

  • forkhead box O3 (FOXO3)
  • forkhead box O3A (foxo3a)
  • forkhead box O3 (foxo3)
  • forkhead box O3 (foxO3)
  • forkhead box O3 (Foxo3)
  • 1110048B16Rik protein
  • 2010203A17Rik protein
  • AF6q21 protein
  • C76856 protein
  • Fkhr2 protein
  • Fkhrl1 protein
  • FKHRL1P2 protein
  • foxO protein
  • FOXO-3 protein
  • FOXO2 protein
  • foxO3 protein
  • FoxO3A protein
  • wu:fb50g02 protein
  • wu:fi33f07 protein
  • xfoxo3 protein
  • zgc:92176 protein

Protein level used designations for Forkhead Box O3 Proteins (FOXO3)

forkhead box O3 , forkhead box O3A , fb50g02 , fi33f07 , forkhead box O protein , forkhead box protein O3-like , forkhead box protein O3 , forkhead homolog (rhabdomyosarcoma) like 1 , forkhead in rhabdomyosarcoma-like 1 , forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 , forkhead box O3a , forkhead protein FKHR2 , xFoxO3 , forkhead box O3A transcription factor

GENE ID SPECIES
445015 Canis lupus familiaris
494532 Danio rerio
462921 Pan troglodytes
700731 Macaca mulatta
100066558 Equus caballus
100125025 Xenopus (Silurana) tropicalis
100303473 Saccoglossus kowalevskii
100406446 Callithrix jacchus
100451077 Pongo abelii
100600519 Nomascus leucogenys
2309 Homo sapiens
56484 Mus musculus
444992 Xenopus laevis
481954 Canis lupus familiaris
733621 Sus scrofa
294515 Rattus norvegicus
535530 Bos taurus
100713179 Cavia porcellus
421769 Gallus gallus
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