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Browse our FOXO3 Proteins (FOXO3)

Full name:
Forkhead Box O3 Proteins (FOXO3)
On www.antibodies-online.com are 9 Forkhead Box O3 (FOXO3) Proteins from 5 different suppliers available. Additionally we are shipping FOXO3 Antibodies (295) and FOXO3 Kits (38) and many more products for this protein. A total of 354 FOXO3 products are currently listed.
Synonyms:
1110048B16Rik, 2010203A17Rik, AF6q21, C76856, Fkhr2, Fkhrl1, FKHRL1P2, foxO, FOXO-3, FOXO2, foxO3, FoxO3A, wu:fb50g02, wu:fi33f07, xfoxo3, zgc:92176
list all proteins Gene Name GeneID UniProt
FOXO3 2309 O43524
FOXO3 56484 Q9WVH4
Rat FOXO3 FOXO3 294515  

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FOXO3 Proteins (FOXO3) by Origin

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Top referenced FOXO3 Proteins

  1. Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2712289 : Thompson, Larson, Vidrine, Barrios, Navarro, Meyers, Simms, Prajapati, Chitsike, Hellman, Baker, Watkins: FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function. in Journal of immunology (Baltimore, Md. : 1950) 2015 (PubMed)

More Proteins for FOXO3 Interaction Partners

Zebrafish Forkhead Box O3 (FOXO3) interaction partners

  1. by modulating hypoxia-inducible factor activity via up-regulation of VHL (show VHL Proteins), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.

  2. This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.

Human Forkhead Box O3 (FOXO3) interaction partners

  1. Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a/EGR1 (show EGR1 Proteins)/SIRT1 (show SIRT1 Proteins) signaling, and AKT (show AKT1 Proteins) and p300 (show EP300 Proteins) negatively regulate this process via Bim (show BCL2L11 Proteins) upregulation.

  2. the accumulation of reactive oxygen species (ROS (show ROS1 Proteins)) in cells expressing JAK2V617F compromises the NHE-1 (show SLC9A1 Proteins)/Bcl-xL (show BCL2L1 Proteins) deamidation pathway by repressing NHE-1 (show SLC9A1 Proteins) upregulation in response to DNA damage. hematopoietic stem cells (HSCs), FOXO3A is largely localized within the nuclei despite the presence of JAK2V617F mutation, suggesting that JAK2 (show JAK2 Proteins)-FOXO signaling has a different effect on progenitors compared with stem cells.

  3. PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/FoxO3a signaling pathway role in melanoma cells

  4. High FOXO3a and p38 expression could predict the response to cetuximab in patients with CRC harbouring WT KRAS.

  5. Kaplan-Meier survival analysis showed that pancreatic ductal adenocarcinoma patients with negative forkhead box P1 (show FOXP1 Proteins) and forkhead box O3a expression survived significantly shorter than patients with positive forkhead box P1 (show FOXP1 Proteins) and forkhead box O3a expression (p = 0.000).

  6. The aims of this study were to quantify the mortality risk for the longevity-associated genotype and to discover the particular cause(s) of death associated with FOXO3 G allele in older Americans of diverse ancestry.

  7. These data suggest that miR (show MLXIP Proteins)-592 may promote the progression and metastasis, in part, by targeting FoxO3A in colorectal cancer

  8. This study indicates that CKII (show CSNK2A1 Proteins) can modulate the intracellular reactive oxygen species level via FoxO3a.

  9. by modulating hypoxia-inducible factor activity via up-regulation of VHL (show VHL Proteins), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.

  10. Glucocorticoids treatment was found to rescue FOXO3a expression both in SLE mice and in SLE patients.

Mouse (Murine) Forkhead Box O3 (FOXO3) interaction partners

  1. results indicate that DNA damage accrued as a result of elevated ROS in Foxo3(-/-) mutant HSPC is at least partially reversible

  2. Foxo1 (show FOXO1 Proteins), Foxo3a, and Foxo4 (show FOXO4 Proteins) in chondrocytes regulate endochondral bone formation.

  3. Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 (show SIRT3 Proteins) enrichment within the mitochondria and subsequent upregulation of FoxO3a-mediated mitochondria gene expression of PGC-1alpha and SOD2 (show SOD2 Proteins).

  4. Regulatory loop between FOXO3 and lipid droplets is required for intestinal inflammation.

  5. Maternal diabetes induced caspase 3 (show CASP3 Proteins)-dependent apoptosis in Sca1 (show ATXN1 Proteins)(+) cardiac progenitor cells derived from embryonic day 17.5 (E17.5). Both maternal diabetes and high glucose in vitro activated the pro-apoptotic transcription factor, Forkhead O 3a (FoxO3a) via dephosphorylation at threonine 32 (Thr (show TRH Proteins)-32) residue.

  6. Mechanistically, exercise-induced nuclear transcription factor FOXO3 binds to the CHCHD4 (show CHCHD4 Proteins) promoter and represses its expression, preventing the translocation of p53 (show TP53 Proteins) to the mitochondria and thereby increasing p53 (show TP53 Proteins) nuclear localization.

  7. Kit inactivation within oocytes also led to premature ovarian failure, albeit via a contrasting phenotype. Despite normal initial complements of primordial follicles, oocytes remained dormant with arrested oocyte maturation. Foxo3 protein localization in the nucleus versus cytoplasm explained both mutant phenotypes.

  8. Glucocorticoids treatment was found to rescue FOXO3a expression both in SLE mice and in SLE patients.

  9. the activation of ERK5 (show MAPK7 Proteins)-AKT (show AKT1 Proteins)-FoxO3a signaling pathways by fluid shear stress resulted in a decreased expression of FasL (show FASL Proteins) and Bim (show BCL2L11 Proteins) and an inhibition of caspase-3 (show CASP3 Proteins) activation, which exerts a protective effect that prevents osteoblasts from apoptosis.

  10. Our results suggest that FoxO3a exerts a negative control over mTOR (show FRAP1 Proteins), and its loss could result in autophagic defects in LD associated with laforin (show EPM2A Proteins) deficiency.

Pig (Porcine) Forkhead Box O3 (FOXO3) interaction partners

  1. These results indicate that myostatin (show MSTN Proteins) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (show NR3C1 Proteins) binding to its promoter.

  2. In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)

  3. PTEN, FOXO3A and PKB (show AKT1 Proteins) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

  4. Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.

  5. FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea

Cow (Bovine) Forkhead Box O3 (FOXO3) interaction partners

  1. NO/protein kinase (show CDK7 Proteins) G (PKG (show PRKG1 Proteins))-dependent downregulation of PGC-1 alpha and the ROS (show ROS1 Proteins) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 Proteins) signaling pathway and subsequent inactivation of transcription factor Foxo3a.

  2. FOXO is a key regulator of ROS (show ROS1 Proteins)-induced apoptosis in mammalian cells.

FOXO3 Protein Profile

Protein Summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.

Alternative names and synonyms associated with FOXO3

  • forkhead box O3 (FOXO3)
  • forkhead box O3A (foxo3a)
  • forkhead box O3 (foxo3)
  • forkhead box O3 (foxO3)
  • forkhead box O3 (Foxo3)
  • 1110048B16Rik protein
  • 2010203A17Rik protein
  • AF6q21 protein
  • C76856 protein
  • Fkhr2 protein
  • Fkhrl1 protein
  • FKHRL1P2 protein
  • foxO protein
  • FOXO-3 protein
  • FOXO2 protein
  • foxO3 protein
  • FoxO3A protein
  • wu:fb50g02 protein
  • wu:fi33f07 protein
  • xfoxo3 protein
  • zgc:92176 protein

Protein level used designations for Forkhead Box O3 Proteins (FOXO3)

forkhead box O3 , forkhead box O3A , fb50g02 , fi33f07 , forkhead box O protein , forkhead box protein O3-like , forkhead box protein O3 , forkhead homolog (rhabdomyosarcoma) like 1 , forkhead in rhabdomyosarcoma-like 1 , forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 , forkhead box O3a , forkhead protein FKHR2 , xFoxO3 , forkhead box O3A transcription factor

GENE ID SPECIES
445015 Canis lupus familiaris
494532 Danio rerio
462921 Pan troglodytes
700731 Macaca mulatta
100066558 Equus caballus
100125025 Xenopus (Silurana) tropicalis
100303473 Saccoglossus kowalevskii
100406446 Callithrix jacchus
100451077 Pongo abelii
100600519 Nomascus leucogenys
2309 Homo sapiens
56484 Mus musculus
444992 Xenopus laevis
481954 Canis lupus familiaris
733621 Sus scrofa
294515 Rattus norvegicus
535530 Bos taurus
100713179 Cavia porcellus
421769 Gallus gallus
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