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Browse our FOXO3 Proteins (FOXO3)

Full name:
Forkhead Box O3 Proteins (FOXO3)
On are 8 Forkhead Box O3 (FOXO3) Proteins from 5 different suppliers available. Additionally we are shipping FOXO3 Antibodies (298) and FOXO3 Kits (42) and many more products for this protein. A total of 361 FOXO3 products are currently listed.
1110048B16Rik, 2010203A17Rik, AF6q21, C76856, Fkhr2, Fkhrl1, FKHRL1P2, foxO, FOXO-3, FOXO2, foxO3, FoxO3A, wu:fb50g02, wu:fi33f07, xfoxo3, zgc:92176
list all proteins Gene Name GeneID UniProt
FOXO3 2309 O43524
FOXO3 56484 Q9WVH4
Rat FOXO3 FOXO3 294515  

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FOXO3 Proteins (FOXO3) by Origin

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Top referenced FOXO3 Proteins

  1. Human FOXO3 Protein expressed in Wheat germ - ABIN1354383 : Lützner, Kalbacher, Krones-Herzig, Rösl: FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop. in PLoS ONE 2012 (PubMed)

More Proteins for FOXO3 Interaction Partners

Zebrafish Forkhead Box O3 (FOXO3) interaction partners

  1. This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.

Human Forkhead Box O3 (FOXO3) interaction partners

  1. FOXO1A (show FOXO1 Proteins) gene polymorphic site rs4943794 is associated with an acquisition of old and senescent age and with women's longevity. FOXO3A gene polymorphic site rs3800231 is associated with longevity in both women and men.

  2. data provide new clues for the essential role of miR (show MLXIP Proteins)-223 in the regulation of anti-Mtb (show NCAPG2 Proteins)-directed immune responses, which relies on the regulation of FOXO3 expression

  3. FOXO3a is a relevant mediator of the antiproliferative effects of MSA (show TPO Proteins).

  4. this study demonstrated that JC induced the apoptosis of hepatocellular carcinoma (HCC (show FAM126A Proteins)) cells by activating Akt (show AKT1 Proteins)/Foxo signaling pathway and increasing intracellular ROS (show ROS1 Proteins) levels.

  5. FOXO3a mRNA expression levels in breast cancer patients correlated with metastasis-free survival.

  6. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 (show CDKN1A Proteins) and CDK2 (show CDK2 Proteins).

  7. FOXO3-dependent gene regulation is generally mediated not through uniquely bound regions but through regions occupied by both FOXK2 (show FOXK2 Proteins) and FOXO3 where both factors play a regulatory role.

  8. These results suggest that the antitumor effects of paclitaxel in breast cancer are mediated by activation of the AMPK (show PRKAA1 Proteins)/EF1alpha/FOXO3a signaling pathway.

  9. Porphyromonas gingivalis-induced reactive oxygen species activate FOXO transcription factors through JNK (show MAPK8 Proteins) signalling, and that FOXO1 (show FOXO1 Proteins) controls oxidative stress responses, inflammatory cytokine production and cell survival.

  10. overexpression of the IGF-1R (show IGF1R Proteins), and activation of GSK3beta and FOXO3a might be the molecular mechanisms underlying the development of liver cirrhosis

Mouse (Murine) Forkhead Box O3 (FOXO3) interaction partners

  1. SIRT6 (show SIRT6 Proteins) up-regulates AMP (show TMPRSS5 Proteins)/ATP and then activates the AMPK (show PRKAA1 Proteins)-FoxO3alpha axis and further initiates the downstream antioxidant-encoding gene expression, thereby decreasing cellular levels of oxidative stress, and mediating cardioprotection in ischemic heart

  2. Kit ligand (show KITLG Proteins) regulates the subcellular localization of FOXO3 in the neonatal mouse ovary.

  3. These data suggest a role for FoxO3a in the maintenance of genome integrity in response to DNA damage that is mediated by H2AX via yet unknown mechanisms.

  4. mice. In vitro assays revealed enhanced survival capacity of Myc (show MYC Proteins)-driven cells lacking FoxO3, but no change in cell cycling was detected

  5. Results point to an antioxidant defense mechanism presented by Sirt3 (show SIRT3 Proteins) through the activation of Foxo3a, in microglia

  6. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 (show CDK2 Proteins).

  7. GL-V9 attenuated DSS (show PMP22 Proteins)-induced colitis against oxidative stress by up-regulating Trx-1 (show TXN Proteins) via activation of AMPK (show PRKAA1 Proteins)/FOXO3a pathway.

  8. The effect of Sirt1 (show SIRT1 Proteins) stimulators on osteoclastogenesis was abrogated in cells lacking FoxO1 (show FOXO1 Proteins), FoxO3, and FoxO4 (show FOXO4 Proteins).

  9. Results point to FOXO3 as a potential node that couples mitochondrial metabolism with HSC (show FUT1 Proteins) homeostasis. These findings have critical implications for mechanisms that promote malignant transformation and aging of blood stem and progenitor cells.

  10. PXR (show NR1I2 Proteins) activation stimulates EGF (show EGF Proteins)-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 from accelerating cell-cycle progression.

Pig (Porcine) Forkhead Box O3 (FOXO3) interaction partners

  1. In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)

  2. PTEN, FOXO3A and PKB (show AKT1 Proteins) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

  3. Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.

  4. FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea

Cow (Bovine) Forkhead Box O3 (FOXO3) interaction partners

  1. NO/protein kinase (show CDK7 Proteins) G (PKG (show PRKG1 Proteins))-dependent downregulation of PGC-1 alpha and the ROS (show ROS1 Proteins) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 Proteins) signaling pathway and subsequent inactivation of transcription factor Foxo3a.

  2. FOXO is a key regulator of ROS (show ROS1 Proteins)-induced apoptosis in mammalian cells.

FOXO3 Protein Profile

Protein Summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.

Alternative names and synonyms associated with FOXO3

  • forkhead box O3 (FOXO3)
  • forkhead box O3A (foxo3a)
  • forkhead box O3 (foxo3)
  • forkhead box O3 (foxO3)
  • forkhead box O3 (Foxo3)
  • 1110048B16Rik protein
  • 2010203A17Rik protein
  • AF6q21 protein
  • C76856 protein
  • Fkhr2 protein
  • Fkhrl1 protein
  • FKHRL1P2 protein
  • foxO protein
  • FOXO-3 protein
  • FOXO2 protein
  • foxO3 protein
  • FoxO3A protein
  • wu:fb50g02 protein
  • wu:fi33f07 protein
  • xfoxo3 protein
  • zgc:92176 protein

Protein level used designations for Forkhead Box O3 Proteins (FOXO3)

forkhead box O3 , forkhead box O3A , fb50g02 , fi33f07 , forkhead box O protein , forkhead box protein O3-like , forkhead box protein O3 , forkhead homolog (rhabdomyosarcoma) like 1 , forkhead in rhabdomyosarcoma-like 1 , forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 , forkhead box O3a , forkhead protein FKHR2 , xFoxO3 , forkhead box O3A transcription factor

445015 Canis lupus familiaris
494532 Danio rerio
462921 Pan troglodytes
700731 Macaca mulatta
100066558 Equus caballus
100125025 Xenopus (Silurana) tropicalis
100303473 Saccoglossus kowalevskii
100406446 Callithrix jacchus
100451077 Pongo abelii
100600519 Nomascus leucogenys
2309 Homo sapiens
56484 Mus musculus
444992 Xenopus laevis
481954 Canis lupus familiaris
733621 Sus scrofa
294515 Rattus norvegicus
535530 Bos taurus
100713179 Cavia porcellus
421769 Gallus gallus
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