Browse our FOXO3 Proteins (FOXO3)

Full name:
Forkhead Box O3 Proteins (FOXO3)
On www.antibodies-online.com are 9 Forkhead Box O3 (FOXO3) Proteins from 5 different suppliers available. Additionally we are shipping FOXO3 Antibodies (305) and FOXO3 Kits (42) and many more products for this protein. A total of 369 FOXO3 products are currently listed.
Synonyms:
1110048B16Rik, 2010203A17Rik, AF6q21, C76856, Fkhr2, Fkhrl1, FKHRL1P2, foxO, FOXO-3, FOXO2, foxO3, FoxO3A, wu:fb50g02, wu:fi33f07, xfoxo3, zgc:92176
list all proteins Gene Name GeneID UniProt
FOXO3 2309 O43524
FOXO3 56484 Q9WVH4
Rat FOXO3 FOXO3 294515  

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FOXO3 Proteins (FOXO3) by Origin

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Top referenced FOXO3 Proteins

  1. Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2712289 : Thompson, Larson, Vidrine, Barrios, Navarro, Meyers, Simms, Prajapati, Chitsike, Hellman, Baker, Watkins: FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function. in Journal of immunology (Baltimore, Md. : 1950) 2015 (PubMed)

More Proteins for FOXO3 Interaction Partners

Zebrafish Forkhead Box O3 (FOXO3) interaction partners

  1. by modulating hypoxia-inducible factor activity via up-regulation of VHL (show VHL Proteins), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.

  2. This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.

Human Forkhead Box O3 (FOXO3) interaction partners

  1. Data suggest that forkhead box O3A protein (FoxO3a) might be a prognostic biomarker or a potential therapeutic target in glioblastoma.

  2. our data demonstrated that FOXO3 is essential for CD44 expression and the properties of cancer stem cells (CSCs). Our data also indicated that patients with high FOXO3 activation signatures had poor prognoses. This evidence suggested that cGMP induction and FOXO3 inhibition could be ideal candidates for pancreatic CSC

  3. adipose stem cell extract regulates Abeta (show APP Proteins)-induced mitochondrial apoptosis via regulation of P53 (show TP53 Proteins)/foxo3a pathway

  4. Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F (show HNRNPF Proteins), SIRTUIN-1 (show SIRT1 Proteins), and FOXO3alpha than nondiabetic kidneys.

  5. acetylation is permissive for generation of the apoptotic form of FOXO3 and the activity of SIRT1 (show SIRT1 Proteins) and particularly SIRT7 (show SIRT7 Proteins) regulate this process in vivo, allowing control of monocyte apoptosis in response to LPS (show IRF6 Proteins).

  6. ectopic expression of the Foxo3P, Foxo3 circular RNA and Foxo3 mRNA could all suppress tumor growth and cancer cell proliferation and survival.

  7. overall survival and progression-free survival were not found to be affected by FOXO3a expression. Cytoplasmic expression of FOXO3a is frequently found in retinoblastoma and may be involved in pathogenesis

  8. In prostate cancer, FOXO3a, and YB-1 (show YBX1 Proteins) play inverse reciprocal roles as a tumor-suppressor gene and oncogene (show RAB1A Proteins), respectively, regulated by ERK (show EPHB2 Proteins) signaling.

  9. miR (show MLXIP Proteins)-34a/sirtuin-1 (show SIRT1 Proteins)/foxo3a might play an important role in genistein reversal of ox-LDL-induced oxidative damage in HUVECs.

  10. Results indicate that cordycepin promotes caveolin-1 (CAV1 (show CAV1 Proteins))upregulation to enhance c-jun N-terminal kinase (JNK)/forkhead box O3A protein (Foxo3a) signaling pathway activation, inducing apoptosis in lung cancer cells.

Mouse (Murine) Forkhead Box O3 (FOXO3) interaction partners

  1. Data, including data from studies using transgenic/knockout mice, suggest that FoxO3 activation via post-translational phosphorylation can both induce and maintain autophagic activities in renal tubule epithelium in response to injury from unilateral ureteral obstruction; under these conditions, nuclear expression of FoxO3 is up-regulated in hypoxic proximal tubules exhibiting high levels of autophagy.

  2. The Foxo3-Eomes (show EOMES Proteins) pathway is central to achieve the complete specialized gene program required for pathogenic Th1 (show HAND1 Proteins) cell differentiation.

  3. these results show that Cdk5 (show CDK5 Proteins)-mediated phospho-regulation of Foxo3 can activate several genes that promote neuronal death and aberrant Abeta (show APP Proteins) processing, thereby contributing to the progression of neurodegenerative pathologies.

  4. the transcription factor Forkhead box O3 (FoxO3) was found to be an essential regulator of the maintenance of pluripotency in dormant embryonic stem cells.

  5. Loss of Foxo3 function resulted in more severe arthritis in vivo (both clinically and histologically) and was associated with higher titers of anticollagen antibodies and interleukin-6 (show IL6 Proteins) in the blood.

  6. results indicate that DNA damage accrued as a result of elevated ROS in Foxo3(-/-) mutant HSPC is at least partially reversible

  7. Foxo1 (show FOXO1 Proteins), Foxo3a, and Foxo4 (show FOXO4 Proteins) in chondrocytes regulate endochondral bone formation.

  8. Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 (show SIRT3 Proteins) enrichment within the mitochondria and subsequent upregulation of FoxO3a-mediated mitochondria gene expression of PGC-1alpha and SOD2 (show SOD2 Proteins).

  9. Regulatory loop between FOXO3 and lipid droplets is required for intestinal inflammation.

  10. Maternal diabetes induced caspase 3 (show CASP3 Proteins)-dependent apoptosis in Sca1 (show ATXN1 Proteins)(+) cardiac progenitor cells derived from embryonic day 17.5 (E17.5). Both maternal diabetes and high glucose in vitro activated the pro-apoptotic transcription factor, Forkhead O 3a (FoxO3a) via dephosphorylation at threonine 32 (Thr (show TRH Proteins)-32) residue.

Pig (Porcine) Forkhead Box O3 (FOXO3) interaction partners

  1. These results indicate that myostatin (show MSTN Proteins) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (show NR3C1 Proteins) binding to its promoter.

  2. In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)

  3. PTEN, FOXO3A and PKB (show AKT1 Proteins) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

  4. Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.

  5. FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea

Cow (Bovine) Forkhead Box O3 (FOXO3) interaction partners

  1. NO/protein kinase (show CDK7 Proteins) G (PKG (show PRKG1 Proteins))-dependent downregulation of PGC-1 alpha and the ROS (show ROS1 Proteins) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 Proteins) signaling pathway and subsequent inactivation of transcription factor Foxo3a.

  2. FOXO is a key regulator of ROS (show ROS1 Proteins)-induced apoptosis in mammalian cells.

FOXO3 Protein Profile

Protein Summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.

Alternative names and synonyms associated with FOXO3

  • forkhead box O3 (FOXO3)
  • forkhead box O3A (foxo3a)
  • forkhead box O3 (foxo3)
  • forkhead box O3 (foxO3)
  • forkhead box O3 (Foxo3)
  • 1110048B16Rik protein
  • 2010203A17Rik protein
  • AF6q21 protein
  • C76856 protein
  • Fkhr2 protein
  • Fkhrl1 protein
  • FKHRL1P2 protein
  • foxO protein
  • FOXO-3 protein
  • FOXO2 protein
  • foxO3 protein
  • FoxO3A protein
  • wu:fb50g02 protein
  • wu:fi33f07 protein
  • xfoxo3 protein
  • zgc:92176 protein

Protein level used designations for Forkhead Box O3 Proteins (FOXO3)

forkhead box O3 , forkhead box O3A , fb50g02 , fi33f07 , forkhead box O protein , forkhead box protein O3-like , forkhead box protein O3 , forkhead homolog (rhabdomyosarcoma) like 1 , forkhead in rhabdomyosarcoma-like 1 , forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 , forkhead box O3a , forkhead protein FKHR2 , xFoxO3 , forkhead box O3A transcription factor

GENE ID SPECIES
445015 Canis lupus familiaris
494532 Danio rerio
462921 Pan troglodytes
700731 Macaca mulatta
100066558 Equus caballus
100125025 Xenopus (Silurana) tropicalis
100303473 Saccoglossus kowalevskii
100406446 Callithrix jacchus
100451077 Pongo abelii
100600519 Nomascus leucogenys
2309 Homo sapiens
56484 Mus musculus
444992 Xenopus laevis
481954 Canis lupus familiaris
733621 Sus scrofa
294515 Rattus norvegicus
535530 Bos taurus
100713179 Cavia porcellus
421769 Gallus gallus
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