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Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2712289
Thompson, Larson, Vidrine, Barrios, Navarro, Meyers, Simms, Prajapati, Chitsike, Hellman, Baker, Watkins: FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function. in Journal of immunology (Baltimore, Md. : 1950) 2015
Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2721367
Nott, Cheng, Gao, Lin, Gjoneska, Ko, Minhas, Zamudio, Meng, Zhang, Jin, Tsai: Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. in Nature neuroscience 2016
by modulating hypoxia-inducible factor activity via up-regulation of VHL (show VHL Proteins), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
NOTCH1 (show NOTCH1 Proteins) inhibits activation of ATM (show ATM Proteins) by impairing the formation of an ATM (show ATM Proteins)-FOXO3a-KAT5 (show KAT5 Proteins) complex.
FOXO3 is required to induce autophagy and thereby reduce elevated reactive oxygen species levels.
A total of 41 differentially expressed genes, such as SOCS3 (show SOCS3 Proteins), VAPA (show VAPA Proteins), and COL5A2 (show COL5A2 Proteins), are speculated to have roles in the pathogenesis of acute myocardial infarction; 2 transcription factors FOXO3 and MYBL2 (show MYBL2 Proteins), and 2 miRNAs hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-21-5p and hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-30c-5p may be involved in the regulation of the expression of these differentially expressed genes.
Downregulation of PKC (show PRRT2 Proteins) induces senescence through the AKT (show AKT1 Proteins)-FoxO3a-ROS (show ROS1 Proteins)-p53 (show TP53 Proteins)-p21(Cip1/WAF1 (show CDKN1A Proteins)) pathway in HCT116 and HEK293 cells.
we demonstrated that REP1 blocked the nuclear trans-localization of FOXO3 through physically interacting with FOXO3, thereby suppressing FOXO3-mediated apoptosis. Importantly, the inhibition of REP1 combined with 5-FU treatment could lead to significant retarded tumor growth in a xenograft tumor model of human cancer cells
TLR4 (show TLR4 Proteins) and C5aR (show C5AR1 Proteins) crosstalk in dendritic cells induces a core regulatory network of RSK2 (show RPS6KA3 Proteins), PI3Kbeta, SGK1 (show SGK1 Proteins), and FOXO transcription factors.
FoxO3a is an early stress response protein to glucose toxicity in diabetic conditions.
In cigarette smoke extract stimulated bronchial epithelial cells, carbocysteine increased cell proliferation, and SIRT1 (show SIRT1 Proteins) and FoxO3 nuclear expression, and reduced beta galactosidase (show GLB1 Proteins) and survivin (show BIRC5 Proteins) expression.
geminin (show GMNN Proteins) selectively couples the transcription factor forkhead box O3 (FoxO3) to HDAC3 (show HDAC3 Proteins), thereby specifically facilitating FoxO3 deacetylation.
Data suggest that forkhead box O3A protein (FoxO3a) might be a prognostic biomarker or a potential therapeutic target in glioblastoma.
MiR (show MLXIP Proteins)-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.
Our results show for the first time that DC FOXO3 expression and function is altered in females. In vitro results indicate that these differences may be the result of exposure to estrogen. These differences may be critical considerations for the enhancement of immunotherapy for cancer.
Data, including data from studies using transgenic/knockout mice, suggest that FoxO3 activation via post-translational phosphorylation can both induce and maintain autophagic activities in renal tubule epithelium in response to injury from unilateral ureteral obstruction; under these conditions, nuclear expression of FoxO3 is up-regulated in hypoxic proximal tubules exhibiting high levels of autophagy.
The Foxo3-Eomes (show EOMES Proteins) pathway is central to achieve the complete specialized gene program required for pathogenic Th1 (show HAND1 Proteins) cell differentiation.
these results show that Cdk5 (show CDK5 Proteins)-mediated phospho-regulation of Foxo3 can activate several genes that promote neuronal death and aberrant Abeta (show APP Proteins) processing, thereby contributing to the progression of neurodegenerative pathologies.
the transcription factor Forkhead box O3 (FoxO3) was found to be an essential regulator of the maintenance of pluripotency in dormant embryonic stem cells.
Loss of Foxo3 function resulted in more severe arthritis in vivo (both clinically and histologically) and was associated with higher titers of anticollagen antibodies and interleukin-6 (show IL6 Proteins) in the blood.
results indicate that DNA damage accrued as a result of elevated ROS in Foxo3(-/-) mutant HSPC is at least partially reversible
Foxo1 (show FOXO1 Proteins), Foxo3a, and Foxo4 (show FOXO4 Proteins) in chondrocytes regulate endochondral bone formation.
Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 (show SIRT3 Proteins) enrichment within the mitochondria and subsequent upregulation of FoxO3a-mediated mitochondria gene expression of PGC-1alpha and SOD2 (show SOD2 Proteins).
These results indicate that myostatin (show MSTN Proteins) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (show NR3C1 Proteins) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (show AKT1 Proteins) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
NO/protein kinase (show CDK7 Proteins) G (PKG (show PRKG1 Proteins))-dependent downregulation of PGC-1 alpha and the ROS (show ROS1 Proteins) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 Proteins) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (show ROS1 Proteins)-induced apoptosis in mammalian cells.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like