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Browse our MDM4-binding Protein (MDM4) ELISA Kits

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Mdm4-binding Protein ELISA Kits (MDM4)
On www.antibodies-online.com are 7 Mdm4-binding Protein (MDM4) ELISA Kits from 4 different suppliers available. Additionally we are shipping MDM4-binding Protein Antibodies (141) and MDM4-binding Protein Proteins (10) and many more products for this protein. A total of 166 MDM4-binding Protein products are currently listed.
Synonyms:
4933417N07Rik, AA414968, AL023055, AU018793, AU021806, C85810, HDMX, Mdmx, MRP1, wu:fa09h09, wu:fi33d10

MDM4-binding Protein (MDM4) ELISA Kits by Reactivity

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More ELISA Kits for MDM4-binding Protein Interaction Partners

Human Mdm4-binding Protein (MDM4) interaction partners

  1. These findings suggest that Mdm2 (show MDM2 ELISA Kits) splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 ELISA Kits)/Mdm2 (show MDM2 ELISA Kits)-Mdm4 via a RING domain-mediated biochemical mechanism.

  2. AXL (show AXL ELISA Kits) overexpression or activation through growth arrest-specific 6 (Gas6 (show GAS6 ELISA Kits)) ligand stimulation increases MDMX and MDM2 (show MDM2 ELISA Kits) protein levels and decreases p53 (show TP53 ELISA Kits) activity.

  3. p53 (show TP53 ELISA Kits) stabilization, along with antagonism of its signaling partners, MDM2 (show MDM2 ELISA Kits) and MDMX, is a promising strategy for anticancer targeted therapy. (Review)

  4. identified a novel Her4 (show ERBB4 ELISA Kits)-induced posttranslational modification on MDMX

  5. MDM4 SNP34091 polymorphism may function as a protective factor against cancer risk.

  6. Individuals harboring the MDM4 SNP34091AC/CC genotypes had a significantly elevated risk for serous ovarian cancer, particularly high-grade serous ovarian cancer. No association between SNP34091 genotypes and endometrial cancer risk was observed.

  7. The kinetic and thermodynamic characterization of the MDM2 (show MDM2 ELISA Kits)-MDM4 complex was performed with two complementary approaches: atomic force spectroscopy and surface plasmon resonance.

  8. The combination of MDM2 (show MDM2 ELISA Kits) and MDM4 expression is an independent predictor in patients undergoing radical cystectomy for muscle-invasive bladder cancer.

  9. These results suggest that secondary intermolecular interaction is important in p53 (show TP53 ELISA Kits) regulation by MDMX, which may represent a common phenomenon in complexes containing multidomain proteins.

  10. Authors show that the EMT (show ITK ELISA Kits) phenotype in multiple cellular models and in clinical prostate and breast cancer samples is associated with a decrease in MDM2 (show MDM2 ELISA Kits) and increase in MDMX expression.

Zebrafish Mdm4-binding Protein (MDM4) interaction partners

  1. Data indicate that knockdown of the Mdm2 (show MDM2 ELISA Kits) and Mdm4 caused dramatic accumulation of mutant p53 protein (show TP53 ELISA Kits).

  2. crystal structure of N-terminal domain of Mdmx bound to 15-residue p53 (show TP53 ELISA Kits) peptide was determined; structure reveals that although principle features of Mdm2 (show MDM2 ELISA Kits)-p53 (show TP53 ELISA Kits) interaction are preserved, the Mdmx hydrophobic cleft on which the p53 (show TP53 ELISA Kits) peptide binds is altered

Mouse (Murine) Mdm4-binding Protein (MDM4) interaction partners

  1. These findings suggest that Mdm2 (show MDM2 ELISA Kits) splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 ELISA Kits)/Mdm2 (show MDM2 ELISA Kits)-Mdm4 via a RING domain-mediated biochemical mechanism.

  2. both MDM2 (show MDM2 ELISA Kits) and MDMX deletion-caused pancreatic defects are completely rescued by loss of p53 (show TP53 ELISA Kits), verifying the crucial role of the MDM2 (show MDM2 ELISA Kits) and/or MDMX in regulating p53 (show TP53 ELISA Kits) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.

  3. we failed to detect any increase in p53 (show TP53 ELISA Kits) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (show TP53 ELISA Kits)-/- mice restored the fertility of females. This study is the first to show that Mdm2 (show MDM2 ELISA Kits), but not Mdm4, has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.

  4. Data show that the Mdm4-p73 (show ARHGAP24 ELISA Kits) axis cannot override the dominant role of p53 (show TP53 ELISA Kits) in development and tumorigenesis and that Mdm4 and p73 (show ARHGAP24 ELISA Kits) interaction during development and tumorigenesis suggests new insight into the role of p53 (show TP53 ELISA Kits) family members.

  5. MDM4/HIPK2 (show HIPK2 ELISA Kits)/p53 (show TP53 ELISA Kits) cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.

  6. MDMx degradation associated with neuronal death occurs via caspase (show CASP3 ELISA Kits) activation in neurons, and that the progressive loss of MDMx protein represents a potential mechanism of Abeta (show APP ELISA Kits)-induced neuronal death during disease progression in AD

  7. our results show MDM4-MDM2 (show MDM2 ELISA Kits)/p53 (show TP53 ELISA Kits)-IGF1R (show IGF1R ELISA Kits) as an original regulatory mechanism for CNS regeneration

  8. Increased Mdm4-S mRNA levels might correlate with more aggressive cancers without encoding significant amounts of a potential oncoprotein.

  9. results reveal a novel p53 (show TP53 ELISA Kits)- and Mdm2 (show MDM2 ELISA Kits)-independent oncogenic function of Mdmx that provides new insight into the many cancers that overexpress Mdmx.

  10. both MDM2 (show MDM2 ELISA Kits) and MDMX are required for monitoring p53 (show TP53 ELISA Kits) activity during lens development, and they may function independently or synergistically to control p53 (show TP53 ELISA Kits) and maintain normal lens morphogenesis

MDM4-binding Protein (MDM4) Antigen Profile

Antigen Summary

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Alternative names and synonyms associated with MDM4-binding Protein (MDM4)

  • Mdm4 p53 binding protein homolog (mdm4) Elisa Kit
  • Mdm4 p53 binding protein homolog (mouse) (MDM4) Elisa Kit
  • Mdm4 p53 binding protein homolog (mouse) (Mdm4) Elisa Kit
  • transformed 3T3 cell double minute 4 homolog (mouse) (mdm4) Elisa Kit
  • transformed mouse 3T3 cell double minute 4 (Mdm4) Elisa Kit
  • 4933417N07Rik Elisa Kit
  • AA414968 Elisa Kit
  • AL023055 Elisa Kit
  • AU018793 Elisa Kit
  • AU021806 Elisa Kit
  • C85810 Elisa Kit
  • HDMX Elisa Kit
  • Mdmx Elisa Kit
  • MRP1 Elisa Kit
  • wu:fa09h09 Elisa Kit
  • wu:fi33d10 Elisa Kit

Protein level used designations for Mdm4-binding Protein (MDM4) ELISA Kits

double minute 4 protein , mdm2-like p53-binding protein , p53-binding protein Mdm4 , protein Mdm4 , MDM4-related protein 1 , double minute 4, human homolog of; p53-binding protein , protein Mdmx , Mdm4, transformed 3T3 cell double minute 4, p53 binding protein , double minute 4 homolog , transformed mouse 3T3 cell double minute 4

GENE ID SPECIES
398466 Xenopus laevis
4194 Homo sapiens
478939 Canis lupus familiaris
514225 Bos taurus
304798 Rattus norvegicus
334932 Danio rerio
17248 Mus musculus
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