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Browse our MDM4-binding Protein (MDM4) ELISA Kits

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Mdm4-binding Protein ELISA Kits (MDM4)
On are 7 Mdm4-binding Protein (MDM4) ELISA Kits from 4 different suppliers available. Additionally we are shipping MDM4-binding Protein Antibodies (131) and MDM4-binding Protein Proteins (10) and many more products for this protein. A total of 156 MDM4-binding Protein products are currently listed.
4933417N07Rik, AA414968, AL023055, AU018793, AU021806, C85810, HDMX, Mdmx, MRP1, wu:fa09h09, wu:fi33d10

MDM4-binding Protein (MDM4) ELISA Kits by Reactivity

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More ELISA Kits for MDM4-binding Protein Interaction Partners

Human Mdm4-binding Protein (MDM4) interaction partners

  1. The phosphate group of pTyr99 imposes extensive steric clashes with the C-terminus of p53 (show TP53 ELISA Kits) peptide and induces a significant lateral shift of the peptide ligand, decreasing the binding affinity of MDMX for p53 (show TP53 ELISA Kits).

  2. CETSA was able to validate stapled peptide binding to Mdm2 (show MDM2 ELISA Kits) and Mdm4.

  3. MDM4/HIPK2 (show HIPK2 ELISA Kits)/p53 (show TP53 ELISA Kits) cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.

  4. MDM4 rs4245739 single nucleotide polymorphism contributes to small cell lung cancer risk and support the notion that gene 3'-UTR (show UTS2R ELISA Kits) genetic variants, impacting miRNA-binding, might modify small cell lung cancer susceptibility.

  5. These results identify Mdmx growth dependency in wt p53 (show TP53 ELISA Kits) expressing breast cancer across a range of subtypes. Based on our findings, we propose that Mdmx targeting is an attractive strategy for treating breast cancer harboring wt p53 (show TP53 ELISA Kits)

  6. MDM4 overexpression is related to complex karyotype-acute myeloid leukemia (show BCL11A ELISA Kits) with wild-type TP53 (show TP53 ELISA Kits) and might play a pathogenic role by inhibiting p53 (show TP53 ELISA Kits)-signal pathway.

  7. MDMX exerts oncogenic activity via suppression of RB.

  8. We show using reporter gene assays and endogenous MDM4 expression analyses that miR (show MLXIP ELISA Kits)-191-5p and miR (show MLXIP ELISA Kits)-887 have a specific affinity for the rs4245739 SNP C-allele in prostate cancer

  9. MDM4 mutation identified in a glioma patient was associated with loss of the putative MDM4 target site. Therefore, let-7 binding to MDM4 is implicated in the DNA damage response

  10. Finally, a strong association between the expression of EEF1A2 (show EEF1A2 ELISA Kits), phosphorylated AKT (show AKT1 ELISA Kits) and MDM4 was observed in human HCC (show FAM126A ELISA Kits) samples. Strong activation of the EEF1A2 (show EEF1A2 ELISA Kits)/PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits)/MDM4 signaling pathway was observed in HCC (show FAM126A ELISA Kits) patients.

Zebrafish Mdm4-binding Protein (MDM4) interaction partners

  1. Data indicate that knockdown of the Mdm2 (show MDM2 ELISA Kits) and Mdm4 caused dramatic accumulation of mutant p53 protein (show TP53 ELISA Kits).

  2. crystal structure of N-terminal domain of Mdmx bound to 15-residue p53 (show TP53 ELISA Kits) peptide was determined; structure reveals that although principle features of Mdm2 (show MDM2 ELISA Kits)-p53 (show TP53 ELISA Kits) interaction are preserved, the Mdmx hydrophobic cleft on which the p53 (show TP53 ELISA Kits) peptide binds is altered

Mouse (Murine) Mdm4-binding Protein (MDM4) interaction partners

  1. MDM4/HIPK2 (show HIPK2 ELISA Kits)/p53 (show TP53 ELISA Kits) cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.

  2. MDMx degradation associated with neuronal death occurs via caspase (show CASP3 ELISA Kits) activation in neurons, and that the progressive loss of MDMx protein represents a potential mechanism of Abeta (show APP ELISA Kits)-induced neuronal death during disease progression in AD

  3. our results show MDM4-MDM2 (show MDM2 ELISA Kits)/p53 (show TP53 ELISA Kits)-IGF1R (show IGF1R ELISA Kits) as an original regulatory mechanism for CNS regeneration

  4. Increased Mdm4-S mRNA levels might correlate with more aggressive cancers without encoding significant amounts of a potential oncoprotein.

  5. results reveal a novel p53 (show TP53 ELISA Kits)- and Mdm2 (show MDM2 ELISA Kits)-independent oncogenic function of Mdmx that provides new insight into the many cancers that overexpress Mdmx.

  6. both MDM2 (show MDM2 ELISA Kits) and MDMX are required for monitoring p53 (show TP53 ELISA Kits) activity during lens development, and they may function independently or synergistically to control p53 (show TP53 ELISA Kits) and maintain normal lens morphogenesis

  7. Decreased Mdm4 levels improves the survival of mice expressing wild-type p53 (show TP53 ELISA Kits), but not that of mice expressing a p53 (show TP53 ELISA Kits) hypomorph lacking the proline-rich domain.

  8. identify Mdm4 as one of these key mRNAs that senses the defects in the spliceosomal machinery and transduces the signal to activate the p53 (show TP53 ELISA Kits) response

  9. The work demonstrates that the ability of MDM4 to enhance p53 (show TP53 ELISA Kits) stability is actually a specific property of MDM4 accomplished upon DNA damage.

  10. Mdm4 was depleted by infecteing with wtHAdV or a mutant virus lacking the E1B (show BCKDHB ELISA Kits)-55K gene (dl 1520).

MDM4-binding Protein (MDM4) Antigen Profile

Antigen Summary

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Alternative names and synonyms associated with MDM4-binding Protein (MDM4)

  • Mdm4 p53 binding protein homolog (mdm4) Elisa Kit
  • Mdm4 p53 binding protein homolog (mouse) (MDM4) Elisa Kit
  • Mdm4 p53 binding protein homolog (mouse) (Mdm4) Elisa Kit
  • transformed 3T3 cell double minute 4 homolog (mouse) (mdm4) Elisa Kit
  • transformed mouse 3T3 cell double minute 4 (Mdm4) Elisa Kit
  • 4933417N07Rik Elisa Kit
  • AA414968 Elisa Kit
  • AL023055 Elisa Kit
  • AU018793 Elisa Kit
  • AU021806 Elisa Kit
  • C85810 Elisa Kit
  • HDMX Elisa Kit
  • Mdmx Elisa Kit
  • MRP1 Elisa Kit
  • wu:fa09h09 Elisa Kit
  • wu:fi33d10 Elisa Kit

Protein level used designations for Mdm4-binding Protein (MDM4) ELISA Kits

double minute 4 protein , mdm2-like p53-binding protein , p53-binding protein Mdm4 , protein Mdm4 , MDM4-related protein 1 , double minute 4, human homolog of; p53-binding protein , protein Mdmx , Mdm4, transformed 3T3 cell double minute 4, p53 binding protein , double minute 4 homolog , transformed mouse 3T3 cell double minute 4

398466 Xenopus laevis
4194 Homo sapiens
478939 Canis lupus familiaris
514225 Bos taurus
304798 Rattus norvegicus
334932 Danio rerio
17248 Mus musculus
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