Browse our Retinoblastoma 1 Proteins (RB1)

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Retinoblastoma 1 Proteins (RB1)
On www.antibodies-online.com are 16 Retinoblastoma 1 (RB1) Proteins from 8 different suppliers available. Additionally we are shipping Retinoblastoma 1 Antibodies (628) and Retinoblastoma 1 Kits (40) and many more products for this protein. A total of 754 Retinoblastoma 1 products are currently listed.
Synonyms:
OSRC, P105-RB, PP110, pRb, Rb, Rb-1, RB1, RB11, zgc:154147
list all proteins Gene Name GeneID UniProt
RB1 5925 P06400
RB1 19645 P13405
RB1 24708 P33568

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Retinoblastoma 1 Proteins (RB1) by Origin

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More Proteins for Retinoblastoma 1 Interaction Partners

Human Retinoblastoma 1 (RB1) interaction partners

  1. RB1 deficiency promotes cancer cell proliferation in part by enhancing mitochondrial function and identify tigecycline as a clinically approved drug for RB1-deficient triple negative breast cancer.

  2. this paper shows that patients with estrogen receptor (show ESR1 Proteins) positive breast cancer expressing high Rb loss-of-function have significantly worse recurrence free survival compared to those with low Rb loss-of-function

  3. Combinatorial PX-866 and Raloxifene Decrease Rb Phosphorylation, Cyclin E2 (show CCNE2 Proteins) Transcription, and Proliferation of MCF-7 Breast Cancer Cells

  4. TYROBP (show TYROBP Proteins) influences a batch of genes that are related to Alzheimer's disease; ZNF329 and RB1 significantly regulate those 'mesenchymal' gene expression signature genes for brain tumors. By merely leveraging gene expression data, Context Based Dependency Network (CBDN) can efficiently infer the existence of gene-gene interactions as well as their regulatory directions.

  5. Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (show E2F1 Proteins) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 (show CDK4 Proteins) inhibitors in breast cancer for the development of more effective combination therapies.

  6. Here, we introduce a transcriptional signature to specifically track CDK2 (show CDK2 Proteins) activity. It responds to genetic and chemical perturbations in the CDK (show CDK4 Proteins)-RB-E2F (show E2F1 Proteins) axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 (show CDK2 Proteins) activity during cell cycle progression

  7. The N-Terminal phosphorylation of RB by p38 (show CRK Proteins) bypasses its inactivation by cyclin (show PCNA Proteins)-dependent kinases and prevents proliferation in cancer cells.

  8. Suggest frequent Rb1 deficiency as a possible driver molecular event in superficial acral fibromyxoma.

  9. The expression of Rb and MeCP2 in patients with B-cell non-Hodgkin's lymphoma (B-NHL) showed that positive staining for MeCP2 or Rb was significantly lower in B-NHL tumor tissues, and these changes were significantly and negatively correlated with the grade of B-NHL.

  10. Inhibition of Rb phosphorylation by depleting cyclin D or using CDK4/6 (show CDK4 Proteins) inhibitors releases Rb-mediated mTORC2 (show CRTC2 Proteins) suppression. This, in turn, leads to elevated Akt (show AKT1 Proteins) activation to confer resistance to chemotherapeutic drugs in Rb-proficient cells, which can be attenuated with Akt (show AKT1 Proteins) inhibitors.

Mouse (Murine) Retinoblastoma 1 (RB1) interaction partners

  1. Combined deletion of Vhl (show VHL Proteins), Trp53 (show TP53 Proteins) and Rb1 specifically in renal epithelial cells in mice caused clear cell renal cell carcinoma (show MOK Proteins).

  2. The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 (show E2F1 Proteins) to recruit EZH2 (show EZH2 Proteins) to diverse repeat sequences.

  3. The N-Terminal phosphorylation of RB by p38 (show CRK Proteins) bypasses its inactivation by cyclin (show PCNA Proteins)-dependent kinases and prevents proliferation in cancer cells.

  4. SUMO1 (show SUMO1 Proteins) conjugation of RB and Lamin A/C (show LMNA Proteins) is modulated by the SUMO protease SENP1 (show SENP1 Proteins) and that sumoylation of both proteins is required for their interaction.

  5. Inhibition of Rb phosphorylation by depleting cyclin D or using CDK4/6 (show CDK4 Proteins) inhibitors releases Rb-mediated mTORC2 (show CRTC2 Proteins) suppression. This, in turn, leads to elevated Akt (show AKT1 Proteins) activation to confer resistance to chemotherapeutic drugs in Rb-proficient cells, which can be attenuated with Akt (show AKT1 Proteins) inhibitors.

  6. The data presented here support a hypothesis in which RB1 and TP53 (show TP53 Proteins) loss in prostate cancer derepresses Ezh2 (show EZH2 Proteins) and Sox2 (show SOX2 Proteins) factors, creating a stem cell-like epigenetic environment permissive for lineage plasticity

  7. systems-level control of cell cycle arrest by pRB (show PGR Proteins)-E2F (show E2F1 Proteins) and p27 (show CDKN1B Proteins)-CDK (show CDK4 Proteins) regulation, is reported.

  8. RB is necessary for the recruitment of the BRG1 ATPase to DNA double-strand breaks, which stimulates DNA end resection and homologous recombination

  9. Findings implicate Rb1 in the regulation of the THO ribonucleoprotein complex.

  10. contribution of these precursors to the Rb(+/-) adipose phenotype is driven, at least in part, by interaction with BMP7 (show BMP7 Proteins) pathway

Zebrafish Retinoblastoma 1 (RB1) interaction partners

  1. Our results indicate that Rb-Raf-1 (show RAF1 Proteins) interaction plays an important role in spontaneous hair cell regeneration in zebrafish

  2. our analysis of zebrafish rb1 mutants reveals a previously unknown yet critical role for rb1 during retinotectal tract development and visual function.

  3. Zebrafish usp39 (show USP37 Proteins) regulates embryonic pituitary homeostasis by targeting rb1 and e2f4 (show E2F4 Proteins) expression, respectively, contributing to increased adenohypophyseal sensitivity to these altered cell cycle regulators

Retinoblastoma 1 (RB1) Protein Profile

Protein Summary

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Alternative names and synonyms associated with Retinoblastoma 1 (RB1)

  • retinoblastoma 1 (including osteosarcoma) (RB1)
  • retinoblastoma 1 (RB1)
  • Retinoblastoma-associated protein (rb)
  • retinoblastoma 1 (Rb1)
  • retinoblastoma 1 (rb1)
  • OSRC protein
  • P105-RB protein
  • PP110 protein
  • pRb protein
  • Rb protein
  • Rb-1 protein
  • RB1 protein
  • RB11 protein
  • zgc:154147 protein

Protein level used designations for Retinoblastoma 1 Proteins (RB1)

retinoblastoma 1 (including osteosarcoma) , retinoblastoma protein 1 , retinoblastoma-associated protein , Retinoblastoma-associated protein , retinoblastoma 1 , retinoblastoma-associated protein-like , retinoblastoma suspectibility protein , pp105 , retinoblastoma protein , Retinoblastoma 1 (including osteosarcoma) , pRb , rb , p104 , spc , retinoblastoma, susceptibility

GENE ID SPECIES
449604 Pan troglodytes
452715 Pan troglodytes
704871 Macaca mulatta
100217687 Taeniopygia guttata
100380330 Salmo salar
100397928 Callithrix jacchus
5925 Homo sapiens
19645 Mus musculus
476915 Canis lupus familiaris
100057080 Equus caballus
24708 Rattus norvegicus
386582 Gallus gallus
777733 Danio rerio
534712 Bos taurus
100716297 Cavia porcellus
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