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Browse our Retinoblastoma 1 Proteins (RB1)

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Retinoblastoma 1 Proteins (RB1)
On www.antibodies-online.com are 12 Retinoblastoma 1 (RB1) Proteins from 6 different suppliers available. Additionally we are shipping Retinoblastoma 1 Antibodies (591) and Retinoblastoma 1 Kits (19) and many more products for this protein. A total of 692 Retinoblastoma 1 products are currently listed.
Synonyms:
OSRC, P105-RB, PP110, pRb, Rb, Rb-1, RB1, RB11, zgc:154147
list all proteins Gene Name GeneID UniProt
RB1 5925 P06400
RB1 19645 P13405
RB1 24708 P33568

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Retinoblastoma 1 Proteins (RB1) by Origin

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More Proteins for Retinoblastoma 1 Interaction Partners

Human Retinoblastoma 1 (RB1) interaction partners

  1. data suggest that overexpression of p-RB1 in basal-parabasal layers of normal cervical epithelium was due to methylation/low functional-linked non-synonimous SNPs of P16 and RBSP3 (show CTDSPL Proteins). This pattern was maintained during cervical carcinogenesis by additional deletion/mutation

  2. Studies suggest that mitochondrial ribosomal protein S18-2 protein, together with the retinoblastoma protein (RB), plays a crucial role in the control on cell stemness and differentiation

  3. Aberrant expressionof Rb is frequently occurred in lung adenocarcinoma patients with EGFR (show EGFR Proteins) mutations.

  4. to our knowledge, the first report of miR (show MLXIP Proteins)-26a targeting Rb1 in colon cancer. The results of this study suggested that miR (show MLXIP Proteins)-26a could serve as a progression biomarker in colorectal cancer. Further validation studies are still needed to confirm our findings.

  5. the effect of low and medium dose radiation on mesenchymal stromal cells (MSCs) with inactivated RB1 gene, was investigated.

  6. a SUMO-deficient Rb mutant results in reduced SUMOylation and phosphorylation, weakened CDK2 (show CDK2 Proteins) binding, and attenuated E2F-1 (show E2F1 Proteins) sequestration.

  7. Statistically significant correlations were found only in Morbus Bowen (preinvasive cutaneous carcinoma) between parameters HPV-p53, p53-pRb and p53-p16.

  8. the previously reported CGI/retrocopy in intron 2 of the RB1 gene (PPP1R26P1) as well as the CGI associated with the retrocopy RPS2P32 identified in this study carry a maternal methylation imprint. In conclusion, these findings shed light on the evolutionary dynamics and constraints of DNA methylation (show HELLS Proteins).

  9. Suppression of tumorigenesis by CADM1 (show CADM1 Proteins) may be mediated by the Rb-E2F1 (show E2F1 Proteins) pathway.

  10. The type and frequency of RB1 mutations in retinoblastoma patients were determined. Those who have deletions in the RB1 gene are at increased risk of chemoresistance and at higher risk of requiring enucleation.

Mouse (Murine) Retinoblastoma 1 (RB1) interaction partners

  1. systems-level control of cell cycle arrest by pRB (show PGR Proteins)-E2F (show E2F1 Proteins) and p27 (show CDKN1B Proteins)-CDK (show CDK4 Proteins) regulation, is reported.

  2. RB is necessary for the recruitment of the BRG1 ATPase to DNA double-strand breaks, which stimulates DNA end resection and homologous recombination

  3. Findings implicate Rb1 in the regulation of the THO ribonucleoprotein complex.

  4. contribution of these precursors to the Rb(+/-) adipose phenotype is driven, at least in part, by interaction with BMP7 (show BMP7 Proteins) pathway

  5. Identify Dyrk1a (show DYRK1A Proteins) as a novel negative regulator of D-cyclin (show PCNA Proteins)-mediated Rb1/E2f (show E2F1 Proteins)-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy.

  6. Expression of Kv10.1 (show KCNG3 Proteins) driven by phosphorylated Rb/E2F1 (show E2F1 Proteins) contributes to G2/M progression of cancer and non-transformed cells.

  7. These findings establish that Rb1 and Skp2 deletions are synthetic lethal and suggest how this lethal relationship might be circumvented, which could help design better therapies for pRb (show PGR Proteins)-deficient cancer.

  8. Results indicate that Rb and p53 (show TP53 Proteins) not only function as tumor suppressors in response to carcinogenic injury, but also in response to non-carcinogenic injury.

  9. Suggest that a principal role for RB1 in development is coordinating the events required for terminal differentiation of erythroid cells.

  10. data also suggest that Rb1 loss is not sufficient to transform post-germinal center B cells and that additional, specific mutations are likely required to cooperate with Rb1 loss to induce malignant transformation.

Zebrafish Retinoblastoma 1 (RB1) interaction partners

  1. Our results indicate that Rb-Raf-1 (show RAF1 Proteins) interaction plays an important role in spontaneous hair cell regeneration in zebrafish

  2. our analysis of zebrafish rb1 mutants reveals a previously unknown yet critical role for rb1 during retinotectal tract development and visual function.

  3. Zebrafish usp39 (show USP37 Proteins) regulates embryonic pituitary homeostasis by targeting rb1 and e2f4 (show E2F4 Proteins) expression, respectively, contributing to increased adenohypophyseal sensitivity to these altered cell cycle regulators

Retinoblastoma 1 (RB1) Protein Profile

Protein Summary

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Alternative names and synonyms associated with Retinoblastoma 1 (RB1)

  • retinoblastoma 1 (including osteosarcoma) (RB1)
  • retinoblastoma 1 (RB1)
  • Retinoblastoma-associated protein (rb)
  • retinoblastoma 1 (Rb1)
  • retinoblastoma 1 (rb1)
  • OSRC protein
  • P105-RB protein
  • PP110 protein
  • pRb protein
  • Rb protein
  • Rb-1 protein
  • RB1 protein
  • RB11 protein
  • zgc:154147 protein

Protein level used designations for Retinoblastoma 1 Proteins (RB1)

retinoblastoma 1 (including osteosarcoma) , retinoblastoma protein 1 , retinoblastoma-associated protein , Retinoblastoma-associated protein , retinoblastoma 1 , retinoblastoma-associated protein-like , retinoblastoma suspectibility protein , pp105 , retinoblastoma protein , Retinoblastoma 1 (including osteosarcoma) , pRb , rb , p104 , spc , retinoblastoma, susceptibility

GENE ID SPECIES
449604 Pan troglodytes
452715 Pan troglodytes
704871 Macaca mulatta
100217687 Taeniopygia guttata
100380330 Salmo salar
100397928 Callithrix jacchus
5925 Homo sapiens
19645 Mus musculus
476915 Canis lupus familiaris
100057080 Equus caballus
24708 Rattus norvegicus
386582 Gallus gallus
777733 Danio rerio
534712 Bos taurus
100716297 Cavia porcellus
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