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Browse our Retinoblastoma 1 Proteins (RB1)

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Retinoblastoma 1 Proteins (RB1)
On www.antibodies-online.com are 10 Retinoblastoma 1 (RB1) Proteins from 7 different suppliers available. Additionally we are shipping Retinoblastoma 1 Antibodies (529) and Retinoblastoma 1 Kits (22) and many more products for this protein. A total of 631 Retinoblastoma 1 products are currently listed.
Synonyms:
OSRC, P105-RB, PP110, pRb, Rb, Rb-1, RB1, RB11, zgc:154147
list all proteins Gene Name GeneID UniProt
RB1 5925 P06400
RB1 19645 P13405
RB1 24708 P33568

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Retinoblastoma 1 Proteins (RB1) by Origin

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Human Retinoblastoma 1 (RB1) interaction partners

  1. Rb knockdown reversed RBEL1 (show C9orf86 Proteins) depletion-induced tumor suppressive effects. In conclusion, the present results suggest that RBEL1 (show C9orf86 Proteins) modulates cell proliferation and G1S transition by inhibiting Rb in osteosarcoma

  2. This inhibition was accompanied by a strong decrease in G1 cyclins (particularly in cyclin D1) and retinoblastoma protein (Rb) phosphorylation

  3. UHRF1 (show UHRF1 Proteins) promotes osteosarcoma cell invasion by downregulating the expression of Ecadherin and increasing epithelialtomesenchymal transition in an Rb1dependent manner.

  4. These results indicate that the loss of RB1 and CDKN2A function induces distinctively different signaling cascades in non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma

  5. The girl with diffuse infiltrating RB was found to be heterozygous for an oncogenic mutation in the RB1 gene that was also carried by both brothers and the father of the family

  6. Coordinate pattern of Rb1+ and ER+ in HGSC and LGSC is 19 and 50%, respectively. Rb1 and P16 show inverse expression pattern according to tumor grade with more frequent Rb1 in low grade vs. more frequent P16 in grade 3 tumors

  7. AR activity was inversely associated with cell proliferation, whereas the expression of Fa complex genes was correlated with elevated cell cycle progression, expression of the E2F transcription factor 1 (E2F1 (show E2F1 Proteins)) and loss of RB1.

  8. gene amplification, p53 (show TP53 Proteins) and Rb disruption, and E2F1 (show E2F1 Proteins) activation drive FOXM1 (show FOXM1 Proteins) expression in epithelial ovarian cancer, and FOXM1 (show FOXM1 Proteins) promotes cell cycle progression in cell models

  9. Loss of OTX2 (show OTX2 Proteins) expression resulted in decreased expression of C-MYC (show MYC Proteins) and CRX (show CRX Proteins), genes previously implicated in retinoblastoma tumorigenesis. Loss of OTX2 (show OTX2 Proteins) expression increased the phosphorylation of RB, a potential mechanism of modulating cell proliferation

  10. The activation of E2Fs is intimately regulated by retinoblastoma 1 (RB1). The RB pathway has been implicated in almost every human malignancy

Mouse (Murine) Retinoblastoma 1 (RB1) interaction partners

  1. Suggest that a principal role for RB1 in development is coordinating the events required for terminal differentiation of erythroid cells.

  2. data also suggest that Rb1 loss is not sufficient to transform post-germinal center B cells and that additional, specific mutations are likely required to cooperate with Rb1 loss to induce malignant transformation.

  3. propose that by repressing Pak1 expression, Rb prevents Rac1 hyperactivity usually associated with cancer and related to cytoskeletal derangements that disrupt cell adhesion, consequently enhancing cancer cell migratory capacity

  4. Data (including data from studies in knockout/transgenic mice) suggest CDKN1B (show CDKN1B Proteins)-RB1-E2F1 (show E2F1 Proteins) (cyclin-dependent kinase inhibitor 1B (show CDKN1B Proteins)-RB1-E2F (show E2F1 Proteins) transcription 1) pathway is essential for SSC (show CYP11A1 Proteins) (spermatogonial stem cell) self-renewal/protection against DNA damage.

  5. A model suited to determine the cellular function of the alternative Rb1 transcript.

  6. data indicate that Pten deletion in osteoblast precursors is sufficient to promote frequent adipogenic, but only rare osteogenic tumors. Rb1 hetero- or homo-zygous co-deletion greatly increases the incidence and the rapidity of onset of adipogenic tumors.

  7. we have discovered a novel role of Rb1 in regulating the entry of primordial oocytes into the pool of growing follicles and signaling between the oocyte and granulosa cells during the protracted process of oocyte growth

  8. Data show that the p16/CDKN2A-cyclin-dependent kinase 4 (CDK4 (show CDK4 Proteins))-RB1 protein pathway is frequently disrupted in fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP).

  9. the genetic interaction between Rb and p53 (show TP53 Proteins) is a critical determinant of the undifferentiated state in normal and tumor cells.

  10. Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas

Zebrafish Retinoblastoma 1 (RB1) interaction partners

  1. Our results indicate that Rb-Raf-1 (show RAF1 Proteins) interaction plays an important role in spontaneous hair cell regeneration in zebrafish

  2. our analysis of zebrafish rb1 mutants reveals a previously unknown yet critical role for rb1 during retinotectal tract development and visual function.

  3. Zebrafish usp39 (show USP37 Proteins) regulates embryonic pituitary homeostasis by targeting rb1 and e2f4 (show E2F4 Proteins) expression, respectively, contributing to increased adenohypophyseal sensitivity to these altered cell cycle regulators

Retinoblastoma 1 (RB1) Protein Profile

Protein Summary

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Alternative names and synonyms associated with Retinoblastoma 1 (RB1)

  • retinoblastoma 1 (including osteosarcoma) (RB1)
  • retinoblastoma 1 (RB1)
  • Retinoblastoma-associated protein (rb)
  • retinoblastoma 1 (Rb1)
  • retinoblastoma 1 (rb1)
  • OSRC protein
  • P105-RB protein
  • PP110 protein
  • pRb protein
  • Rb protein
  • Rb-1 protein
  • RB1 protein
  • RB11 protein
  • zgc:154147 protein

Protein level used designations for Retinoblastoma 1 Proteins (RB1)

retinoblastoma 1 (including osteosarcoma) , retinoblastoma protein 1 , retinoblastoma-associated protein , Retinoblastoma-associated protein , retinoblastoma 1 , retinoblastoma-associated protein-like , retinoblastoma suspectibility protein , pp105 , retinoblastoma protein , Retinoblastoma 1 (including osteosarcoma) , pRb , rb , p104 , spc , retinoblastoma, susceptibility

GENE ID SPECIES
449604 Pan troglodytes
452715 Pan troglodytes
704871 Macaca mulatta
100217687 Taeniopygia guttata
100380330 Salmo salar
100397928 Callithrix jacchus
5925 Homo sapiens
19645 Mus musculus
476915 Canis lupus familiaris
100057080 Equus caballus
24708 Rattus norvegicus
386582 Gallus gallus
777733 Danio rerio
534712 Bos taurus
100716297 Cavia porcellus
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