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Human Retinoblastoma Binding Protein 8 Protein expressed in Wheat germ - ABIN1317559
Unno, Itaya, Taoka, Sato, Tomida, Sakai, Sugasawa, Ishiai, Ikura, Isobe, Kurumizaka, Takata: FANCD2 binds CtIP and regulates DNA-end resection during DNA interstrand crosslink repair. in Cell reports 2014
MRN (Mre11 (show MRE11A Proteins), Rad50 (show RAD50 Proteins), and Nbs1 (show NLRP2 Proteins)) complex, CtIP, and BRCA1 are required for both the removal of Top2 (show TOP2 Proteins)-DNA adducts and the subsequent resection of Top2 (show TOP2 Proteins)-adducted DSB ends.
ATM (show ATM Proteins) activity is required for an early step in resection, leading to ATR activation, CtIP-T818 phosphorylation, and accumulation of CtIP on chromatin.
By promoting CtIP-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 (show CDK1 Proteins) inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.
Data delineates the regulatory mechanisms of GATA3 (show GATA3 Proteins) in DNA double-strand breaks repair and strongly suggests that it might act as a tumor suppressor by promoting CtIP expression and homologous recombination to stabilize genomes.
The results illuminate the important role of Nbs1 (show NBN Proteins) and CtIP in determining the substrates and consequences of human Mre11 (show MRE11A Proteins)/Rad50 (show RAD50 Proteins) nuclease (show DCLRE1C Proteins) activities on protein-DNA lesions.
And-1 interacts with CtIP and that these interactions are required for DNA damage checkpoint maintenance, thereby linking DNA processing with prolonged cell cycle arrest to allow sufficient time for DNA repair.
his shows that 53BP1 (show TP53BP1 Proteins) protects both close and distant DSEs from degradation and that the association of unprotection with distance between DSEs favors ECS capture. Reciprocally, silencing CtIP lessens ECS capture both in control and 53BP1 (show TP53BP1 Proteins)-depleted cells. We propose that close ends are immediately/rapidly tethered and ligated, whereas distant ends first require synapsis of the distant DSEs prior to ligation
Low level of CtIP expression is associated with breast cancer.
Homozygous RBBP8 mutation is associated with microcephaly, intellectual disability, short stature and brachydactyly.
USP4 (show USP4 Proteins) cooperates with CtIP in DNA double-strand break end resection.
CtIP is a DNA damage response protein at the intersection of DNA metabolism. (Review)
Data show that ubiquitin E2 enzymes UBE2D1 (show UBE2D1 Proteins)/2/3 and E3 ligase RNF138 (show RNF138 Proteins) accumulate at DNA-damage sites and act at early resection stages by promoting CtIP protein ubiquitylation and accrual.
BRCA1 and CtIP contribute to DSB resection by recruiting Dna2 to damage sites, thus ensuring the robust DSB resection necessary for efficient homologous recombination.
Q418P nsSNP influences the efficiency of CTIP function in HR repair of DNA DSBs
Ctip1 (show BCL11A Proteins) couples subtype and area specification, enabling specific functional areas to organize precise ratios of appropriate output projections.
work therefore ascribes novel roles for BRCA1 (show BRCA1 Proteins) and CtIP in end-processing and fusion reactions at uncapped telomeres
Data indicate that loss of the CtIP-BRCA1 interaction does not detectably affect resection, maintenance of genomic stability or viability.
The phospho-dependent BRCA1 (show BRCA1 Proteins)-CtIP interaction is not essential for HDR (show GATA3 Proteins)-mediated DSB repair or for tumor suppression.
CtIP contributes to the metabolism of DNA ends during DNA double-strand breaks repair in B lymphocytes.
CtIP-mediated alt-NHEJ has a primary role in translocation formation.
CtIP binds to switch-region DNA and plays a physiological role in microhomology-mediated end joining in a C-NHEJ-proficient environment.
the histone protein H2AX (show H2AFX Proteins) prevents nucleases other than Artemis (show DCLRE1C Proteins) from processing hairpin-sealed coding ends; in the absence of H2AX (show H2AFX Proteins), CtIP can efficiently promote the hairpin opening and resection of DNA ends generated by RAG cleavage
CtIP counteracts Rb-mediated G(1) restraint.
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
retinoblastoma binding protein 8
, CtBP-interacting protein
, DNA endonuclease RBBP8
, ctBP-interacting protein
, retinoblastoma-binding protein 8
, sporulation in the absence of SPO11 protein 2 homolog
, retinoblastoma-binding protein 8-like
, CTBP-interacting protein