Browse our Retinoblastoma Binding Protein 8 Proteins (RBBP8)

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Retinoblastoma Binding Protein 8 Proteins (RBBP8)
On are 4 Retinoblastoma Binding Protein 8 (RBBP8) Proteins from 3 different suppliers available. Additionally we are shipping Retinoblastoma Binding Protein 8 Antibodies (92) and many more products for this protein. A total of 105 Retinoblastoma Binding Protein 8 products are currently listed.
9930104E21Rik, COM1, CTIP, DKFZp469K0714, JWDS, RBBP-8, RBBP8, RGD1308872, RIM, SAE2, SCKL2
list all proteins Gene Name GeneID UniProt
RBBP8 5932 Q99708
RBBP8 225182 Q80YR6
Rat RBBP8 RBBP8 291787 B1WC58

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Retinoblastoma Binding Protein 8 Proteins (RBBP8) by Origin

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Top referenced Retinoblastoma Binding Protein 8 Proteins

  1. Human Retinoblastoma Binding Protein 8 Protein expressed in Wheat germ - ABIN1317559 : Unno, Itaya, Taoka, Sato, Tomida, Sakai, Sugasawa, Ishiai, Ikura, Isobe, Kurumizaka, Takata: FANCD2 binds CtIP and regulates DNA-end resection during DNA interstrand crosslink repair. in Cell reports 2014 (PubMed)

More Proteins for Retinoblastoma Binding Protein 8 Interaction Partners

Xenopus laevis Retinoblastoma Binding Protein 8 (RBBP8) interaction partners

  1. MRN (Mre11 (show MRE11A Proteins), Rad50 (show RAD50 Proteins), and Nbs1 (show NLRP2 Proteins)) complex, CtIP, and BRCA1 are required for both the removal of Top2 (show TOP2 Proteins)-DNA adducts and the subsequent resection of Top2 (show TOP2 Proteins)-adducted DSB ends.

  2. ATM (show ATM Proteins) activity is required for an early step in resection, leading to ATR activation, CtIP-T818 phosphorylation, and accumulation of CtIP on chromatin.

  3. By promoting CtIP-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 (show CDK1 Proteins) inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.

Human Retinoblastoma Binding Protein 8 (RBBP8) interaction partners

  1. And-1 interacts with CtIP and that these interactions are required for DNA damage checkpoint maintenance, thereby linking DNA processing with prolonged cell cycle arrest to allow sufficient time for DNA repair.

  2. his shows that 53BP1 (show TP53BP1 Proteins) protects both close and distant DSEs from degradation and that the association of unprotection with distance between DSEs favors ECS capture. Reciprocally, silencing CtIP lessens ECS capture both in control and 53BP1 (show TP53BP1 Proteins)-depleted cells. We propose that close ends are immediately/rapidly tethered and ligated, whereas distant ends first require synapsis of the distant DSEs prior to ligation

  3. Low level of CtIP expression is associated with breast cancer.

  4. Homozygous RBBP8 mutation is associated with microcephaly, intellectual disability, short stature and brachydactyly.

  5. USP4 (show USP4 Proteins) cooperates with CtIP in DNA double-strand break end resection.

  6. CtIP is a DNA damage response protein at the intersection of DNA metabolism. (Review)

  7. Data show that ubiquitin E2 enzymes UBE2D1 (show UBE2D1 Proteins)/2/3 and E3 ligase RNF138 (show RNF138 Proteins) accumulate at DNA-damage sites and act at early resection stages by promoting CtIP protein ubiquitylation and accrual.

  8. BRCA1 and CtIP contribute to DSB resection by recruiting Dna2 to damage sites, thus ensuring the robust DSB resection necessary for efficient homologous recombination.

  9. The CtIP 3'UTR is directly targeted by miR (show MLXIP Proteins)-19a and miR (show MLXIP Proteins)-19b.

  10. CtIP interacts with Cdh1 (show CDH1 Proteins) through a conserved KEN box, mutation of which impedes ubiquitylation and downregulation of CtIP both during G1 and after DNA damage in G2.

Mouse (Murine) Retinoblastoma Binding Protein 8 (RBBP8) interaction partners

  1. Q418P nsSNP influences the efficiency of CTIP function in HR repair of DNA DSBs

  2. Ctip1 (show BCL11A Proteins) couples subtype and area specification, enabling specific functional areas to organize precise ratios of appropriate output projections.

  3. work therefore ascribes novel roles for BRCA1 (show BRCA1 Proteins) and CtIP in end-processing and fusion reactions at uncapped telomeres

  4. Data indicate that loss of the CtIP-BRCA1 interaction does not detectably affect resection, maintenance of genomic stability or viability.

  5. The phospho-dependent BRCA1 (show BRCA1 Proteins)-CtIP interaction is not essential for HDR (show GATA3 Proteins)-mediated DSB repair or for tumor suppression.

  6. CtIP contributes to the metabolism of DNA ends during DNA double-strand breaks repair in B lymphocytes.

  7. CtIP-mediated alt-NHEJ has a primary role in translocation formation.

  8. CtIP binds to switch-region DNA and plays a physiological role in microhomology-mediated end joining in a C-NHEJ-proficient environment.

  9. the histone protein H2AX (show H2AFX Proteins) prevents nucleases other than Artemis (show DCLRE1C Proteins) from processing hairpin-sealed coding ends; in the absence of H2AX (show H2AFX Proteins), CtIP can efficiently promote the hairpin opening and resection of DNA ends generated by RAG cleavage

  10. CtIP counteracts Rb-mediated G(1) restraint.

Retinoblastoma Binding Protein 8 (RBBP8) Protein Profile

Protein Summary

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Alternative names and synonyms associated with Retinoblastoma Binding Protein 8 (RBBP8)

  • retinoblastoma binding protein 8 (RBBP8)
  • retinoblastoma binding protein 8 (rbbp8)
  • retinoblastoma binding protein 8 (LOC100354690)
  • retinoblastoma binding protein 8 (Rbbp8)
  • 9930104E21Rik protein
  • COM1 protein
  • CTIP protein
  • DKFZp469K0714 protein
  • JWDS protein
  • RBBP-8 protein
  • RBBP8 protein
  • RGD1308872 protein
  • RIM protein
  • SAE2 protein
  • SCKL2 protein

Protein level used designations for RBBP8

retinoblastoma binding protein 8 , CtBP-interacting protein , DNA endonuclease RBBP8 , ctBP-interacting protein , retinoblastoma-binding protein 8 , sporulation in the absence of SPO11 protein 2 homolog , retinoblastoma-binding protein 8-like , CTBP-interacting protein , RBBP-8

421071 Gallus gallus
444252 Xenopus laevis
455333 Pan troglodytes
512977 Bos taurus
677718 Macaca mulatta
100174689 Pongo abelii
100354690 Oryctolagus cuniculus
100380142 Xenopus (Silurana) tropicalis
100399729 Callithrix jacchus
100437097 Pongo abelii
100526778 Papio anubis
100604424 Nomascus leucogenys
5932 Homo sapiens
225182 Mus musculus
291787 Rattus norvegicus
480175 Canis lupus familiaris
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