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Browse our SMAD2 Proteins (SMAD2)

Full name:
SMAD, Mothers Against DPP Homolog 2 Proteins (SMAD2)
On are 27 SMAD, Mothers Against DPP Homolog 2 (SMAD2) Proteins from 14 different suppliers available. Additionally we are shipping SMAD2 Antibodies (404) and SMAD2 Kits (29) and many more products for this protein. A total of 481 SMAD2 products are currently listed.
7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2
list all proteins Gene Name GeneID UniProt
SMAD2 4087 Q15796
SMAD2 17126 Q62432
SMAD2 29357 O70436

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SMAD2 Proteins (SMAD2) by Origin

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Top referenced SMAD2 Proteins

  1. Human SMAD2 Protein expressed in Escherichia coli (E. coli) - ABIN667736 : Bonni, Wang, Causing, Kavsak, Stroschein, Luo, Wrana: TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. in Nature cell biology 2001 (PubMed)
    Show all 2 references for ABIN667736

More Proteins for SMAD2 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. The results of this study found that Bptf and TGF-beta (show TGFB1 Proteins)/Smad2 mediate nucleosome remodeling to regulate wnt8a (show WNT8A Proteins) expression and hence neural posteriorization.

  2. Smad2 and Eomesodermin (show EOMES Proteins) a (Eomesa (show EOMES Proteins)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (show EOMES Proteins) forms a general component of the Smad2 signalling complex in zebrafish.

  3. These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.

  4. study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription

  5. Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.

  6. Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. MiR (show MLXIP Proteins)-425 functions as an oncogene (show RAB1A Proteins) by targeting the 3'-UTR of SMAD2 in esophageal squamous cell carcinoma.

  2. The present study thus proposed SEB as an agent able to significantly reduce Smad2/3 expression in colon cancer cells, provoking moderate TGFb growth signaling and the reduction of tumor cell proliferation.

  3. correlation between TGFb1 (show TGFB1 Proteins) and pSmad2 as well as between HtrA1 (show HTRA1 Proteins) and TGFb1 (show TGFB1 Proteins) and the very significant increase of Ki67 (show MKI67 Proteins) in stromal compartment of eutopic endometrium suggest a possible involvement of HtrA1 (show HTRA1 Proteins) in the pathogenesis of endometriosis.

  4. Up-regulation of smad2 is associated with endometrial cancer.

  5. SMAD2 mutations are associated with arterial aneurysms and dissections

  6. data suggest that TGF-beta1 (show TGFB1 Proteins) enhances IGFBP7 (show IGFBP7 Proteins) via Smad2/4 pathways, and that IGFBP7 (show IGFBP7 Proteins) might be involved in the TGF-beta1 (show TGFB1 Proteins)-induced tubular injury in DN.

  7. Studies demonstrated that MUC1 (show MUC1 Proteins)-mediated JNK (show MAPK8 Proteins) activation not only enhances the phosphorylation of Smad2 C-terminal at Ser (show SIGLEC1 Proteins)-465/467 site (Smad2C) through TGF-beta (show TGFB1 Proteins)/TbetaRI (show TGFBR1 Proteins), but also enhances the phosphorylation of Smad2 linker region at Ser (show SIGLEC1 Proteins)-245/250/255 site.

  8. Different signaling pathways are involved in osteitis in CRS (show CARS Proteins) and are activated by the TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling pathway in CRSwNP versus the TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins)-independent signaling pathway in CRSsNP.

  9. smad2 and Erk (show EPHB2 Proteins)/Akt (show AKT1 Proteins) have roles in TGF-beta1 (show TGFB1 Proteins)-induced apoptosis in human gingival epithelial cells

  10. Report inhibition of colorectal cancer stem cell survival and invasive potential by hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-140-5p mediated suppression of Smad2 and autophagy.

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. E2a (show TCF3 Proteins) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

  2. GDF11 (show GDF11 Proteins) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.

  3. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2/3 activity during murine cardiac progenitor cell differentiation.

  2. Smad2 and Smad3 (show SMAD3 Proteins) oppositely modify STAT3 (show STAT3 Proteins)-induced transcription of IL-17A (show IL17A Proteins) and retinoic acid receptor (show RARA Proteins)-related orphan nuclear receptor (show NR1D1 Proteins), RORgammat encoded by Rorc (show RORC Proteins), by acting as a co-activator and co-repressor of STAT3 (show STAT3 Proteins), respectively.

  3. Endoplasmic reticulum stress in hepatic stellar cells promotes liver fibrosis by inducing over expression of SMAD2.

  4. pSmad3L-Ser (show SIGLEC1 Proteins) signalling correlates with carcinogenesis of colon tumors and this work supports the hypothesis that pSmad2/3L-Thr (show TRH Proteins) immunostaining-positive cells are cancer stem cells.

  5. These results suggest that TGF-beta regulates RANKL-induced osteoclastogenesis through reciprocal cooperation between Smad2/3 and c-Fos.

  6. Treatment with geniposide almost completely blocked the phosphorylation of Smad2/3, extracellular signal-regulated kinase (ERK (show EPHB2 Proteins)) and Akt (show AKT1 Proteins) in AML12 cells.

  7. Deficiency of MKP5 (show DUSP10 Proteins) resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 (show DUSP10 Proteins) critically controls inflammation in white adipose tissue and the development of metabolic disorders

  8. Data show that the Notch (show NOTCH1 Proteins) pathway is involved in kidney fibrosis through activation of transforming growth factor beta (TGF-beta)/Smad (show SMAD1 Proteins) proteins 2/3 (Smad2/3) signaling.

  9. Studies indicate that Nodal/Smad2-dependent signals govern initial proximal-distal polarity and formation of the anterior visceral endoderm (AVE).

  10. In conclusion, this study identifies opposing roles for Smad2 and Smad3 (show SMAD3 Proteins) in peritoneal dialysis-associated peritoneal fibrosis

SMAD2 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

  • SMAD family member 2 (SMAD2)
  • SMAD family member 2 (smad2)
  • MAD homolog 2 (Drosophila) (smad2)
  • SMAD family member 2 (Smad2)
  • 7120426M23Rik protein
  • fj43c06 protein
  • hMAD-2 protein
  • hSMAD2 protein
  • JV18 protein
  • JV18-1 protein
  • Madh2 protein
  • Madr2 protein
  • mMad2 protein
  • Smad-2 protein
  • wu:fj43c06 protein
  • Xmad2 protein
  • XSmad2 protein

Protein level used designations for SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

100033843 Equus caballus
496586 Xenopus (Silurana) tropicalis
30639 Danio rerio
4087 Homo sapiens
432023 Xenopus laevis
395247 Gallus gallus
480144 Canis lupus familiaris
100155304 Sus scrofa
516010 Bos taurus
17126 Mus musculus
29357 Rattus norvegicus
455407 Pan troglodytes
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