Browse our SMAD2 Proteins (SMAD2)

Full name:
SMAD, Mothers Against DPP Homolog 2 Proteins (SMAD2)
On are 28 SMAD, Mothers Against DPP Homolog 2 (SMAD2) Proteins from 13 different suppliers available. Additionally we are shipping SMAD2 Antibodies (414) and SMAD2 Kits (40) and many more products for this protein. A total of 502 SMAD2 products are currently listed.
7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2
list all proteins Gene Name GeneID UniProt
SMAD2 4087 Q15796
SMAD2 17126 Q62432
SMAD2 29357 O70436

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SMAD2 Proteins (SMAD2) by Origin

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Top referenced SMAD2 Proteins

  1. Human SMAD2 Protein expressed in Escherichia coli (E. coli) - ABIN667736 : Bonni, Wang, Causing, Kavsak, Stroschein, Luo, Wrana: TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. in Nature cell biology 2001 (PubMed)
    Show all 2 references for 667736

  2. Human SMAD2 Protein expressed in HEK-293 Cells - ABIN2732219 : Atanelishvili, Shirai, Akter, Buckner, Noguchi, Silver, Bogatkevich: M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo. in Translational research : the journal of laboratory and clinical medicine 2016 (PubMed)

More Proteins for SMAD2 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. The results of this study found that Bptf and TGF-beta (show TGFB1 Proteins)/Smad2 mediate nucleosome remodeling to regulate wnt8a (show WNT8A Proteins) expression and hence neural posteriorization.

  2. Smad2 and Eomesodermin (show EOMES Proteins) a (Eomesa (show EOMES Proteins)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (show EOMES Proteins) forms a general component of the Smad2 signalling complex in zebrafish.

  3. These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.

  4. study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription

  5. Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.

  6. Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. In response to TGF-beta (show TGFB1 Proteins), RASSF1A (show RASSF1 Proteins) is recruited to TGF-beta (show TGFB1 Proteins) receptor I and targeted for degradation by the co-recruited E3 ubiquitin ligase (show MUL1 Proteins) ITCH. RASSF1A (show RASSF1 Proteins) degradation is necessary to permit Hippo pathway effector YAP1 (show YAP1 Proteins) association with SMADs and subsequent nuclear translocation of receptor-activated SMAD2.

  2. Smad2 is a key scaffold, allowing RIN1 (show RIN1 Proteins) to act as a GTP (show AK3 Proteins) exchange factor for MFN2 (show MFN2 Proteins)-GTPase (show RACGAP1 Proteins) activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion.

  3. Ang (show ANG Proteins) down-regulate the expression of Col (show HDAC1 Proteins)-I, alpha-SMA (show SMN1 Proteins) and TGF-beta1 (show TGFB1 Proteins)/Smad2/3 and subsequently inhibits fibroblast-myofibroblast transition.

  4. The nuclear importin (show KPNA4 Proteins) IPO5 (show IPO5 Proteins) was identified as a novel interacting protein of SMAD1 (show GARS Proteins). Overexpression of IPO5 (show IPO5 Proteins) in various cell lines specifically increases nuclear localization of BMP receptor (show BMPR1A Proteins)-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 (show IPO5 Proteins) and BMP but not TGF-beta (show TGFB1 Proteins) R-SMADs.

  5. Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta (show TGFB1 Proteins)/Smad2 signaling pathway, but not Smad1 (show GARS Proteins)/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.

  6. the findings show that TIEG1 is highly expressed in human keloids and that it directly binds and represses Smad7 (show SMAD7 Proteins) promoter-mediated activation of TGF-beta (show TGFB1 Proteins)/Smad2 signaling

  7. A significant association was found between the low expression of inhibitory protein SMAD-7 (show SMAD7 Proteins) and both zeta-chain-associated protein kinase (show CDK7 Proteins) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (show GARS Proteins)/8 and lower SMAD-4 (show SMAD4 Proteins) expression in chronic lymphocytic leukemia cells

  8. High expression of SMAD2 is associated with colorectal carcinoma.

  9. this study shows that tolfenamic acid inhibits growth of colon cancer cells through downregulation of Smad2

  10. overexpression of miR29b markedly reduced the expression levels of COL1A1 (show COL1A1 Proteins) and alphaSMA (show ACTA2 Proteins), and decreased the expression and nuclear accumulation of pSmad2/3.

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. Grg4 occupancy at the Xnr1 (show NODAL Proteins) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 from FoxH1 (show FOXH1 Proteins) at the Xnr1 (show NODAL Proteins) enhancer, an essential feature of the transcriptional switch mechanism.

  2. E2a (show TCF3 Proteins) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

  3. GDF11 (show GDF11 Proteins) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.

  4. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Pig (Porcine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. Activin A (show INHBA Proteins) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (show NANOG Proteins) and OCT4 (show POU5F1 Proteins),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (show NANOG Proteins)/OCT4 (show POU5F1 Proteins) expression.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. These results suggest that Nedd9 (show NEDD9 Proteins) is a Smad2/3 target gene implicated in RANKL (show TNFSF11 Proteins)-induced osteoclastogenesis.

  2. In conclusion, TGF-beta (show TGFB1 Proteins) signaling pathway may influence liver fibrosis by incorporating with YB-1 (show YBX1 Proteins), indicating that YB-1 (show YBX1 Proteins) could be a potential target for therapies against liver fibrosis.

  3. miR (show MLXIP Proteins)-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta (show TGFB1 Proteins) receptor 1 and SMAD2.

  4. hese studies revealed that Smad2 plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (show IHH Proteins) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  5. This study found evidence of increased leukocyte phosphorylated-Smad2/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (show TGFB1 Proteins).

  6. Data show that muscle-specific (show EIF3K Proteins) Smad (show SMAD1 Proteins) proteins Smad2/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy.

  7. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (show WNT2 Proteins) pathway, and inhibition of Smad2/3 signaling and Shh (show SHH Proteins) pathways.

  8. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2/3 activity during murine cardiac progenitor cell differentiation.

  9. Smad2 and Smad3 (show SMAD3 Proteins) oppositely modify STAT3 (show STAT3 Proteins)-induced transcription of IL-17A (show IL17A Proteins) and retinoic acid receptor (show RARA Proteins)-related orphan nuclear receptor (show NR1D1 Proteins), RORgammat encoded by Rorc (show RORC Proteins), by acting as a co-activator and co-repressor of STAT3 (show STAT3 Proteins), respectively.

  10. Endoplasmic reticulum stress in hepatic stellar cells promotes liver fibrosis by inducing over expression of SMAD2.

SMAD2 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

  • SMAD family member 2 (SMAD2)
  • SMAD family member 2 (smad2)
  • MAD homolog 2 (Drosophila) (smad2)
  • SMAD family member 2 (Smad2)
  • 7120426M23Rik protein
  • fj43c06 protein
  • hMAD-2 protein
  • hSMAD2 protein
  • JV18 protein
  • JV18-1 protein
  • Madh2 protein
  • Madr2 protein
  • mMad2 protein
  • Smad-2 protein
  • wu:fj43c06 protein
  • Xmad2 protein
  • XSmad2 protein

Protein level used designations for SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

100033843 Equus caballus
496586 Xenopus (Silurana) tropicalis
30639 Danio rerio
4087 Homo sapiens
432023 Xenopus laevis
395247 Gallus gallus
480144 Canis lupus familiaris
100155304 Sus scrofa
516010 Bos taurus
17126 Mus musculus
29357 Rattus norvegicus
455407 Pan troglodytes
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