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Human SMAD2 Protein expressed in HEK-293 Cells - ABIN2732219
Atanelishvili, Shirai, Akter, Buckner, Noguchi, Silver, Bogatkevich: M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo. in Translational research : the journal of laboratory and clinical medicine 2016
The non-Smad (show SMAD1 Proteins) JNK (show MAPK8 Proteins) signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad (show SMAD1 Proteins) pathway, and this nuclear movement is associated with Smad (show SMAD1 Proteins) signal transduction toward the nucleus.
The results of this study found that Bptf and TGF-beta (show TGFB1 Proteins)/Smad2 mediate nucleosome remodeling to regulate wnt8a (show WNT8A Proteins) expression and hence neural posteriorization.
Smad2 and Eomesodermin (show EOMES Proteins) a (Eomesa (show EOMES Proteins)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (show EOMES Proteins) forms a general component of the Smad2 signalling complex in zebrafish.
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis
Data suggest that oncogenic Y-box binding protein 1 (YB-1 (show YBX1 Proteins)) indirectly enhances transforming growth factor beta (TGFbeta (show TGFB1 Proteins)) signaling cascades via Sma (show SMN1 Proteins)/Mad related protein 2 (Smad2)phospho-activation and may represent a promising factor for future diagnosis and therapy of breast cancer.
Asiaticoside hindered the invasive growth of KFs (show GDF6 Proteins) by inhibiting the GDF-9 (show GDF9 Proteins)/MAPK (show MAPK1 Proteins)/Smad (show SMAD1 Proteins) pathway.
High Smad2 expression is associated with invasion and metastasis in pancreatic ductal adenocarcinoma.
Data indicate that miR (show MLXIP Proteins)-206 inhibits neuropilin-1 (NRP1 (show NRP1 Proteins)) and SMAD2 gene expression by directly binding to their 3'-UTRs.
Results show that members of the Activin branch of the TGFbeta (show TGFB1 Proteins) signaling pathway, namely Put and Smad2, are autonomously required for cell and tissue growth in the Drosophila larval salivary gland.
CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.
cells expressing mutant huntingtin (show HTT Proteins) have a dysregulated transcriptional response to epidermal growth factor (show EGF Proteins) stimulation
CRT (show SLC6A8 Proteins) regulates TGF-beta1 (show TGFB1 Proteins)-induced-EMT (show ITK Proteins) through modulating Smad (show SMAD1 Proteins) signaling
P311 (show C5orf13 Proteins) is a novel TGFbeta1 (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
human epidermal growth factor receptor (show EGFR Proteins) 2 (HER-2 (show ERBB2 Proteins)) levels, were correlated well with TSP50 (show PRSS50 Proteins)/p-Samd2 (show SARM1 Proteins)/3 and TSP50 (show PRSS50 Proteins)/p27 (show PAK2 Proteins) expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50 (show PRSS50 Proteins)-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer
Grg4 occupancy at the Xnr1 (show NODAL Proteins) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 from FoxH1 (show FOXH1 Proteins) at the Xnr1 (show NODAL Proteins) enhancer, an essential feature of the transcriptional switch mechanism.
E2a (show TCF3 Proteins) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
GDF11 (show GDF11 Proteins) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.
Activin A (show INHBA Proteins) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (show NANOG Proteins) and OCT4 (show POU5F1 Proteins),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (show NANOG Proteins)/OCT4 (show POU5F1 Proteins) expression.
the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).
Smad2- and Smad3 (show SMAD3 Proteins)-deficient bone marrow (BM) cells display reduced sensitivity to transforming growth factor-beta (TGFbeta (show TGFB1 Proteins)) inhibition.
Data (including data from studies using knockout mice) suggest Garp/Lrrc32 (show LRRC32 Proteins) is involved in up-regulation of Tgfb3 (show TGFB3 Proteins) and is essential for embryogenesis of palate; Garp (show LRRC32 Proteins) knockout causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Garp (show LRRC32 Proteins) = glycoprotein A repetitions predominant (show LRRC32 Proteins) protein; Tgfb3 (show TGFB3 Proteins) = transforming growth factor beta 3 (show TGFB3 Proteins))
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (show TPM1 Proteins), as a model of immature Leydig cells.
Lnc-LFAR1 binds directly to Smad2/3 and promotes transcription of TGFbeta (show TGFB1 Proteins), Smad2, Smad3 (show SMAD3 Proteins), Notch2 (show NOTCH2 Proteins) and Notch3 (show NOTCH3 Proteins) which, in turn, results in TGFbeta (show TGFB1 Proteins) and Notch (show NOTCH1 Proteins) pathway activation.
the levels of Smad2/3, P-Smad2/3 expressions were decreased, while the level of Smad7 (show SMAD7 Proteins) expression was increased after treatment with osthole.
These findings implicate TGF-beta (show TGFB1 Proteins)-Smad2/3 signaling in activated tissue-resident cardiac fibroblasts as principal mediators of the fibrotic response.
In order to study the translation between mouse model and patients, we evaluated the signature of phosphorylated Sma- and Mad-related protein 2 (pSmad2), as molecular marker of TGF-beta/activin activity, in the kidneys of streptozotocin (STZ)-treated mice compared to that of type 1 diabetes (T1D) patients.
selective inhibition of SMAD3 (show SMAD3 Proteins) or CCT6A (show CCT6A Proteins) efficiently suppresses TGF-beta (show TGFB1 Proteins)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (show TGFB1 Proteins) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (show TGFB1 Proteins) for non-small-cell lung carcinoma.
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
SMAD, mothers against DPP homolog 2
, MAD (mothers against decapentaplegic, Drosophila) homolog 2
, SMA- and MAD-related protein 2
, SMAD 2
, SMAD family member 2
, mothers against DPP homolog 2
, mothers against decapentaplegic homolog 2
, MAD homolog 2
, Sma- and Mad-related protein 2
, mother against DPP homolog 2
, mothers against decapentaplegic-like 2
, Smad 2
, mad-related protein 2