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Browse our SMAD3 (SMAD3) ELISA Kits

Full name:
SMAD, Mothers Against DPP Homolog 3 ELISA Kits (SMAD3)
On www.antibodies-online.com are 54 SMAD, Mothers Against DPP Homolog 3 (SMAD3) ELISA Kits from 14 different suppliers available. Additionally we are shipping SMAD3 Antibodies (474) and SMAD3 Proteins (27) and many more products for this protein. A total of 598 SMAD3 products are currently listed.
Synonyms:
AU022421, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, mad3, Madh3, madh3-A, madh3a, Smad 3, smad3, wu:fa99e03, XenMLP, Xmad3, XSmad3
list all ELISA KIts Gene Name GeneID UniProt
SMAD3 4088 P84022
SMAD3 17127 Q8BUN5
SMAD3 25631 P84025

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More ELISA Kits for SMAD3 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta (show TGFB1 ELISA Kits) control of zebrafish spinal cord development

  2. Nodal signaling and mesendoderm induction depend on Smad2 (show SMAD2 ELISA Kits)/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2 (show SMAD2 ELISA Kits)/3 signaling and embryonic patterning.

  3. although the role of Smad (show SMAD1 ELISA Kits) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap (show TDP2 ELISA Kits) provides insight into a novel Smad (show SMAD1 ELISA Kits) partner that plays an essential role in the fine-tuning of this signal transduction cascade

  4. Smad2 (show SMAD2 ELISA Kits)/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Rabbit SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1 (show TGFB1 ELISA Kits)/Smad3 signaling pathway in chronic heart failure .

  2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

Human SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. signal transducer and activator of transcription (Stat (show STAT1 ELISA Kits))3 (show STAT3 ELISA Kits) represses Smad3 in synergy with the potent negative regulators of TGF-beta (show TGFB1 ELISA Kits) signaling, c-Ski (show SKI ELISA Kits) and SnoN (show SKIL ELISA Kits), whereby renders gefitinib-sensitive HCC827 cells resistant

  2. Therefore, our results demonstrate that autophagy counteracts the EndoMT process triggered by TGF-beta2 (show TGFB2 ELISA Kits) by decreasing the phosphorylation level of Smad3.

  3. Conversely, siRNA-mediated Klotho (show KL ELISA Kits) silencing up-regulated Egr-1 (show EGR1 ELISA Kits), FN, and Col (show HDAC1 ELISA Kits) I expression and the p-Smad3/Smad3 ratio. Moreover, the effects of si-Klotho (show KL ELISA Kits) on Egr-1 (show EGR1 ELISA Kits) expression were abolished by the TGF-beta1 (show TGFB1 ELISA Kits) inhibitor SB-431542. Klotho (show KL ELISA Kits) overexpression can prevent mesangial ECM (show MMRN1 ELISA Kits) production in high-glucose-treated human MCs (show SMCP ELISA Kits), an effect that has been partially attributed to Egr-1 (show EGR1 ELISA Kits) down-regulation facilitated by TGF-beta1 (show TGFB1 ELISA Kits)/Smad3 s...

  4. a novel STAT3 (show STAT3 ELISA Kits)/SMAD3-signaling axis is required for OSM (show OSM ELISA Kits)-mediated senescence.

  5. The protective (T) allele of rs17293632 disrupts a consensus AP-1 (show FOSB ELISA Kits) binding site in a SMAD3 intron 1 enhancer, reduces enhancer activity and SMAD3 expression, altering human arterial smooth muscle cell proliferation to prevent coronary artery disease.

  6. Data suggest a novel role for TGFbeta1/TGFbeta receptor signaling via SMAD3 in regulation of expression of p16-Ink4a/Arf locus in beta-cells and highlight potential of using small molecule inhibitors of TGFbeta1/TGFbeta receptor signaling to promote human b-cell proliferation. (TGFbeta1 = transforming growth factor beta 1; p16-Ink4a = cyclin dependent kinase inhibitor 2A; SMAD3 = SMAD family member 3)

  7. TGF-beta (show TGFB1 ELISA Kits)-treated fibroblasts contained SMAD (show SMAD1 ELISA Kits) complexes that activated a SMAD (show SMAD1 ELISA Kits) target gene in addition to those repressing PPARG (show PPARG ELISA Kits) transcription, the first finding of such dual activity within the same cell. These findings describe in detail novel mechanisms by which TGF-beta (show TGFB1 ELISA Kits) represses PPARG (show PPARG ELISA Kits) transcription, thereby facilitating its own pro-fibrotic activity

  8. Our results suggested that miR (show MLXIP ELISA Kits)-23a-3p contributes to OA progression by directly targeting SMAD3, providing a potential therapeutic target for OA treatment.

  9. Moreover, in PAH model, Smad3, p-Smad3 and Smad4 were all downregulated in lung tissues, and SIS3 (Smad3 inhibitor) could reverse the effects of anti-miR-199a-5p in PAH rats. Our date suggest that miR-199a-5p may function as a regulator of PAH by targeting Smad3, indicating a novel therapeutic strategy for patients with PAH.

  10. Smad 3-specific reduction mediates loss of type I collagen in aged human skin.

Xenopus laevis SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. E2a (show TCF3 ELISA Kits) is necessary to drive transcription of Smad2 (show SMAD2 ELISA Kits)/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

Pig (Porcine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 regulate the activity and stability of myocardin (show MYOCD ELISA Kits)-related transcription factor during epithelial-myofibroblast transition

  2. SP1 (show SP1 ELISA Kits) and SMAD3 are required for high glucose-induced p21(WAF1 (show CDKN1A ELISA Kits)) gene transcription in LLC-PK1 (show PKLR ELISA Kits) cells.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Evaluated the effects of the loss of Smad3 on the development of experimental argon laser-induced choroidal neovascularization (CNV). The size of the CNV induced was significantly smaller in KO mice as compared with WT mice at day 14.

  2. hese studies revealed that Smad2 (show SMAD2 ELISA Kits) plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (show IHH ELISA Kits) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  3. emodin was found to increase the expression level of Sirt1 (show SIRT1 ELISA Kits), which decreased the level of deacetylated Smad3 to attenuate collagen deposition. Furthermore, the data suggested that there was direct binding between emodin and Sirt1 (show SIRT1 ELISA Kits). Sirt1regulated TGFb1 (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits) signaling was involved in silica inhalationinduced lung fibrosis.

  4. HSP27 (show HSPB1 ELISA Kits) expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 (show HSPB1 ELISA Kits) modulates lung fibroblast differentiation through the Smad3 and ERK (show EPHB2 ELISA Kits) pathways.

  5. miR221 targets HMGA2 to inhibit leomycininduced pulmonary fibrosis through the TGFbeta1 (show TGFB1 ELISA Kits)/Smad3 signaling pathway.

  6. Notch3 (show NOTCH3 ELISA Kits) is an important protective factor for cardiac fibrosis in a myocardial infarction model, and the protective effect of Notch3 (show NOTCH3 ELISA Kits) is attributable to its action on TGF-beta1 (show TGFB1 ELISA Kits)/Smad3 signaling.

  7. Smad3 deficiency leads to aortic aneurysms and sudden death in the Smad3 knockout animal model.

  8. TGF-beta1 (show TGFB1 ELISA Kits)-induced inhibition of PPARgamma (show PPARG ELISA Kits) transcription depends on formation of a functional transcriptional regulatory complex that includes Smad3, mSin3A and HDAC1 (show HDAC1 ELISA Kits) at the PPARgamma (show PPARG ELISA Kits) promoter.

  9. Activation of CB2 (show CNR2 ELISA Kits) ameliorates myocardial fibrosis via Nrf2 (show NFE2L2 ELISA Kits)-mediated inhibition of TGF-beta1 (show TGFB1 ELISA Kits)/Smad3 pathway in mice with myocardial infarction.

  10. This study found evidence of increased leukocyte phosphorylated-Smad2 (show SMAD2 ELISA Kits)/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (show TGFB1 ELISA Kits).

Cow (Bovine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2 (show SMAD2 ELISA Kits)/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2 (show SMAD2 ELISA Kits)/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 ELISA Kits) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 ELISA Kits)/5/8 and Smad2 (show SMAD2 ELISA Kits)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 ELISA Kits).

SMAD3 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Alternative names and synonyms associated with SMAD3

  • SMAD family member 3 (SMAD3) Elisa Kit
  • MAD homolog 3a (Drosophila) (smad3a) Elisa Kit
  • mothers against decapentaplegic homolog 3 (LOC100346303) Elisa Kit
  • SMAD family member 3 (smad3) Elisa Kit
  • SMAD family member 3 (Smad3) Elisa Kit
  • AU022421 Elisa Kit
  • HSPC193 Elisa Kit
  • HsT17436 Elisa Kit
  • JV15-2 Elisa Kit
  • LDS1C Elisa Kit
  • LDS3 Elisa Kit
  • mad3 Elisa Kit
  • Madh3 Elisa Kit
  • madh3-A Elisa Kit
  • madh3a Elisa Kit
  • Smad 3 Elisa Kit
  • smad3 Elisa Kit
  • wu:fa99e03 Elisa Kit
  • XenMLP Elisa Kit
  • Xmad3 Elisa Kit
  • XSmad3 Elisa Kit

Protein level used designations for SMAD3

MAD homolog 3 , MAD homolog 3a , MAD, mothers against decapentaplegic homolog 3 , SMA- and MAD-related protein 3 , SMAD, mothers against DPP homolog 3 , hMAD-3 , hSMAD3 , mad homolog JV15-2 , mad protein homolog , mad3 , mothers against DPP homolog 3 , mothers against decapentaplegic homolog 3 , SMAD 3 , TGF beta response effector Smad3 , TGF-beta response effector Smad3 , Smad 3 , mMad3 , MAD (mothers against decapentaplegic, Drosophila) homolog 3 , SMAD family member 3

GENE ID SPECIES
100033845 Equus caballus
58092 Danio rerio
100346303 Oryctolagus cuniculus
4088 Homo sapiens
378633 Xenopus laevis
395132 Gallus gallus
610902 Canis lupus familiaris
397260 Sus scrofa
17127 Mus musculus
25631 Rattus norvegicus
515125 Bos taurus
100731807 Cavia porcellus
443169 Ovis aries
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