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Browse our TRF2 (TERF2) ELISA Kits

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Telomeric Repeat Binding Factor 2 ELISA Kits (TERF2)
On are 9 Telomeric Repeat Binding Factor 2 (TERF2) ELISA Kits from 6 different suppliers available. Additionally we are shipping TRF2 Antibodies (73) and TRF2 Proteins (5) and many more products for this protein. A total of 94 TRF2 products are currently listed.
TERF2, TRBF2, trf2
list all ELISA KIts Gene Name GeneID UniProt
TERF2 7014 Q15554
TERF2 21750 O35144
Rat TERF2 TERF2 361403  

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TRF2 (TERF2) ELISA Kits by Reactivity

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Human Telomeric Repeat Binding Factor 2 (TERF2) interaction partners

  1. TRF2 deficiency led to a 1,5-2 fold increase in the radiosensitivity of hMSC-telo1 (show ATM ELISA Kits) cells through telomere destabilization.

  2. DREEM imaging shows that in contrast to chromatin with DNA wrapping around histones, large TRF2-DNA complexes (with volumes larger than TRF2 tetramers) compact DNA inside TRF2 with portions of folded DNA appearing at the edge of these complexes.

  3. observed that the expression of Sp1 (show PSG1 ELISA Kits) is down-regulated in the TRF2(DeltaBDeltaM)-induced senescence, which was mediated by ATM (show ATM ELISA Kits) and p38 MAPK (show MAPK14 ELISA Kits)

  4. Data show that isoform beta2 of the heregulin (HRGbeta2) localizes at telomeres with the telomere-associated proteins TRF2 and RAP1.

  5. These observations suggest that TRF2 is a good candidate for the attachment of telomeres to the nuclear envelope in somatic cells

  6. Through a combination of biochemical, biophysical and structural approaches, we unveiled a unique mode of assembly between RAP1 (show RABGEF1 ELISA Kits) and TRF2

  7. that a dimer of the shelterin subunit TRF2 wraps approximately 90 bp of DNA through several lysine and arginine residues localized around its homodimerization domain.

  8. TRF2 overexpression results in replication stalling in duplex telomeric repeat tracts and formation of telomeric ultrafine anaphase bridges, ultimately leading to stochastic loss of telomeric sequences.

  9. APB (show RNPEP ELISA Kits) formation induced clustering of telomere repeats, telomere compaction and concomitant depletion of the shelterin protein TRF2 (also known as TERF2).

  10. Study demonstrates that TRF2 interacts with and is sumoylated by PIAS1 (show PIAS1 ELISA Kits) and RNF4 (show RNF4 ELISA Kits) targets SUMO-conjugated TRF2 for ubiquitination, thereby decreasing its stability suggesting that TRF2 status provides a molecular switch that controls its level at telomeres.

Mouse (Murine) Telomeric Repeat Binding Factor 2 (TERF2) interaction partners

  1. Overexpressing TRF2-S and silencing FMRP (show FMR1 ELISA Kits) promotes mRNA entry to axons and enhances axonal outgrowth and neurotransmitter release from presynaptic terminals.

  2. TRF2 binds and transactivates the promoter of the angiogenic tyrosine kinase (show TYRO3 ELISA Kits) platelet-derived growth factor receptor beta (show PDGFRB ELISA Kits) (PDGFRbeta).

  3. role of TRF2 in skin homeostasis, is reported.

  4. shelterin protein TIN2 (show TINF2 ELISA Kits) can protect chromosome ends as a TRF2-tethered TIN2 (show TINF2 ELISA Kits)/TPP1 (show TPP1 ELISA Kits)/POT1 (show POT1 ELISA Kits) complex that lacks a physical connection to TRF1 (show TERF1 ELISA Kits)

  5. We concluded that genomic instability resulting from loss of TRF2 expression provides biological advantages to the cancer stem cell population

  6. Conditional deletion of individual components of shelterin showed that TRF2 was required for the formation and/or maintenance of t-loops, whereas deletion of TRF1 (show TERF1 ELISA Kits), Rap1 (show TERF2IP ELISA Kits), or the POT1 (show POT1 ELISA Kits) proteins (POT1a (show POT1 ELISA Kits) and POT1b) had no effect on the frequency of t-loop occurrence.

  7. TAF7L (show TAF7L ELISA Kits) associates with TRF2 both in vitro and in testis, suggesting that TAF7L (show TAF7L ELISA Kits) likely cooperates directly with TRF2 at promoters of a subset of postmeiotic genes to regulate spermiogenesis.

  8. Experiments in cells from knockout mice showed that uPAR (show PLAUR ELISA Kits) controls the ubiquitin-proteasome system in VSMC & regulates doxorubicin-induced TRF2 ubiquitination and proteasomal degradation via this mechanism.

  9. the molecular properties of TRF2 that are both necessary and sufficient to protect chromosome ends in mouse embryonic fibroblasts: the data support a two-step mechanism for TRF2-mediated end protection

  10. TRF2 provides a crucial link between telomere function and ultraviolet-induced damage repair, whose alteration underlies genomic instability, cancer and aging.

TRF2 (TERF2) Antigen Profile

Antigen Summary

This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.

Alternative names and synonyms associated with TRF2 (TERF2)

  • telomeric repeat binding factor 2 (TERF2) Elisa Kit
  • telomeric repeat binding factor 2 (Terf2) Elisa Kit
  • telomeric repeat binding factor 2 (terf2) Elisa Kit
  • TERF2 Elisa Kit
  • TRBF2 Elisa Kit
  • trf2 Elisa Kit

Protein level used designations for TERF2

telomeric repeat binding factor 2 , TTAGGG repeat-binding factor 2 , telomeric DNA-binding protein , telomeric repeat binding protein 2 , telomeric repeat-binding factor 2 , TTAGGG-repeat binding factor 2 TRF2 , telomeric repeat binding factor a , TTAGGG repeat binding factor 2

454201 Pan troglodytes
704879 Macaca mulatta
100028044 Monodelphis domestica
7014 Homo sapiens
21750 Mus musculus
361403 Rattus norvegicus
489736 Canis lupus familiaris
395598 Gallus gallus
734203 Xenopus laevis
506501 Bos taurus
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