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Results revealed that WEE1 is indispensable for maintaining genomic stability and it functions as a haploinsufficient tumor suppressor.
Wee1 is directly or indirectly involved in the mechanism of the circadian rhythm-dependent changes in docetaxel-induced intestinal damage.
The induction of Wee1 under hypoxia was confirmed both at the mRNA and protein levels.
In this study, we found that the chromosomal wee1 gene is also down-regulated by KLF3 (show KLF3 ELISA Kits).
The regulation of Wee1 by SadA (show BRSK2 ELISA Kits) and SadB (show BRSK1 ELISA Kits) kinases is essential for the differentiation of polarized neurons.
Mammalian Wee1 plays a critical role in maintaining genome integrity and is essential for embryonic survival at the pre-implantation stage of mouse development.
expression of wee1 was directly regulated by the molecular components of the circadian clockwork in the regenerating liver
transcription repressive activity of TBP-related factor 2 (show TBPL1 ELISA Kits) to wee1 promoter needs association with the promoter and TFIIA (show GTF2A1 ELISA Kits)
the suppression of nuclear import of cyclin B1 (show CCNB1 ELISA Kits), the induction of Wee1 kinase activity, and the transient nuclear accumulation of p21(CIP1/WAF1 (show CDKN1A ELISA Kits)) may play important roles in the transient cell cycle delay in response to ionizing radiation
These results highlight the key role of WEE1 suppression to combat glioblastomas. Moreover, it showed beneficial possibilities of WEE1 suppression with different anticancer approaches for neurological malignancies.
Wee1 inhibition potentiates Wip1-dependent tumor sensitization effect by reducing levels of Hipk2 kinase, a negative regulator of Wip1 pathway.
High nuclear expression of WEE1 protein is associated with all glioma grades and types.
Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 (show CDK2 ELISA Kits) or Cyclin A2 (show CCNA2 ELISA Kits) knockdown. These findings support G2 exit as the more significant effect of Wee1 inhibition in pancreatic cancers.
WEE1 is regulated at the translational level by CPEB1 (show CPEB1 ELISA Kits) and miR (show MLXIP ELISA Kits)-15b in a coordinated and cell-cycle-dependent manner.
Data show that proto-oncogene (show RAB1A ELISA Kits) protein Mdm2 (show MDM2 ELISA Kits) inactivation successfully protects tumor suppressor protein (p53 (show TP53 ELISA Kits))-proficient cells against the cytotoxic effects of Wee1 protein inhibition.
nasopharyngeal carcinoma cells depend on CHK1 (show CHEK1 ELISA Kits) and WEE1 activity for growth
data indicate that the activity of the DNA replication machinery, beyond TP53 (show TP53 ELISA Kits) mutation status, determines Wee1 inhibitor sensitivity, and could serve as a selection criterion for Wee1-inhibitor eligible patients
Data show that H3K36me3-deficient cancers can be targeted by inhibition of WEE1 protein.
Report strong synergism observed by combining Chk1 (show CHEK1 ELISA Kits) and Wee1 inhibitors in preclinical models of mantle cell lymphoma.
the identification of a second member of the RNase H2 complex, RNase H2B (show RNASEH2B ELISA Kits), being able to complement the root growth phenotype of WEE1(KO) plants, is reported.
mutant alleles of the genes encoding subunits of the ribonuclease H2 (RNase H2) complex, known for its role in removing ribonucleotides from DNA-RNA duplexes, were identified as suppressor mutants of WEE1 knockout plants.
The plant WEE1 kinase acquired an indirect developmental function that is important for meristem maintenance upon replication stress.
The WEE1 gene is not rate-limiting for cell cycle progression under normal growth conditions but is a critical target of the ATR (show ATR ELISA Kits)-ATM (show ATM ELISA Kits) signaling cascades that inhibit the cell cycle upon activation of the DNA integrity checkpoints.
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.
WEE1 homolog (S. pombe)
, wee1-like protein kinase 2
, Wee1 kinase
, Wee1-like protein kinase
, wee1 tyrosine kinase
, wee1-like protein kinase
, wee1A kinase
, WEE1 tyrosine kinase
, WEE1+ homolog