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Results revealed that WEE1 is indispensable for maintaining genomic stability and it functions as a haploinsufficient tumor suppressor.
Wee1 is directly or indirectly involved in the mechanism of the circadian rhythm-dependent changes in docetaxel-induced intestinal damage.
The induction of Wee1 under hypoxia was confirmed both at the mRNA and protein levels.
In this study, we found that the chromosomal wee1 gene is also down-regulated by KLF3 (show KLF3 Proteins).
The regulation of Wee1 by SadA (show BRSK2 Proteins) and SadB (show BRSK1 Proteins) kinases is essential for the differentiation of polarized neurons.
Mammalian Wee1 plays a critical role in maintaining genome integrity and is essential for embryonic survival at the pre-implantation stage of mouse development.
expression of wee1 was directly regulated by the molecular components of the circadian clockwork in the regenerating liver
transcription repressive activity of TBP-related factor 2 (show TBPL1 Proteins) to wee1 promoter needs association with the promoter and TFIIA (show GTF2A1 Proteins)
the suppression of nuclear import of cyclin B1 (show CCNB1 Proteins), the induction of Wee1 kinase activity, and the transient nuclear accumulation of p21(CIP1/WAF1 (show CDKN1A Proteins)) may play important roles in the transient cell cycle delay in response to ionizing radiation
Data show that proto-oncogene (show RAB1A Proteins) protein Mdm2 (show MDM2 Proteins) inactivation successfully protects tumor suppressor protein (p53 (show TP53 Proteins))-proficient cells against the cytotoxic effects of Wee1 protein inhibition.
nasopharyngeal carcinoma cells depend on CHK1 (show CHEK1 Proteins) and WEE1 activity for growth
data indicate that the activity of the DNA replication machinery, beyond TP53 (show TP53 Proteins) mutation status, determines Wee1 inhibitor sensitivity, and could serve as a selection criterion for Wee1-inhibitor eligible patients
Data show that H3K36me3-deficient cancers can be targeted by inhibition of WEE1 protein.
Report strong synergism observed by combining Chk1 (show CHEK1 Proteins) and Wee1 inhibitors in preclinical models of mantle cell lymphoma.
These data provide a rationale for further evaluation of the combination of Wee1 and Chk1 (show CHEK1 Proteins)/2 inhibitors in malignant melanoma.
This study showed that WEE1 (rs10770042; coding) associated with Alzheimer disease.
WEE1 is a valid target of the miR-17-92 cluster in leukemia.
Study shows that CHD5 is a Nucleosome remodeling and deacetylase complex-associated transcriptional repressor and identifies WEE1 as one of the CHD5-regulated genes that may link CHD5 to tumor suppression.
identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex.
the identification of a second member of the RNase H2 complex, RNase H2B (show RNASEH2B Proteins), being able to complement the root growth phenotype of WEE1(KO) plants, is reported.
mutant alleles of the genes encoding subunits of the ribonuclease H2 (RNase H2) complex, known for its role in removing ribonucleotides from DNA-RNA duplexes, were identified as suppressor mutants of WEE1 knockout plants.
The plant WEE1 kinase acquired an indirect developmental function that is important for meristem maintenance upon replication stress.
The WEE1 gene is not rate-limiting for cell cycle progression under normal growth conditions but is a critical target of the ATR-ATM (show ATM Proteins) signaling cascades that inhibit the cell cycle upon activation of the DNA integrity checkpoints.
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.
WEE1 homolog (S. pombe)
, wee1-like protein kinase 2
, Wee1 kinase
, Wee1-like protein kinase
, wee1 tyrosine kinase
, wee1-like protein kinase
, wee1A kinase
, WEE1 tyrosine kinase
, WEE1+ homolog