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Data show that oligosaccharyltransferase (OST) activity is dysregulated in three prime exonuclease 1 (show TREX1 Proteins) knockout (Trex1 (show TREX1 Proteins)-/-) cells.
AGER1 provides protection against AGE-induced reactive oxygen species generation via NADPH oxidase (show NOX1 Proteins) and protein kinase C delta (show PKCd Proteins).
Found a 22 bp deletion and a missense mutation in DDOST.
The common SNPs tested in DDOST, PRKCSH (show PRKCSH Proteins) and LGALS3 (show LGALS3 Proteins) do not seem to be associated with diabetic micro- or macrovascular complications or with type 1 diabetes in Finnish patients.
This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.
, oligosaccaryltransferase 48kDa subunit
, oligosaccharyltransferase 48kD subunit
, dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
, dolichyl-diphosphooligosaccharide-protein glycosyltransferase
, dolichyl-diphosphooligosaccharide protein glycosyltransferase
, oligosaccharyltransferase OST48
, DDOST 48 kDa subunit
, oligosaccharyl transferase 48 kDa subunit
, OST 50 kDa subunit
, oligosaccharyltransferase 48 kDa subunit
, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
, Oligosaccharyl transferase 48 kDa subunit
, advanced glycation endproduct receptor 1
, dolichyl-diphosphooligosaccharide-protein glycotransferase
, oligosaccharyltransferase subunit 48
, dolichyl-di-phosphooligosaccharide-protein glycotransferase
, dolichyl-diphosphooligosaccharide--protein glycotransferase
, glycosylation site-binding chain