Browse our Glutaredoxin 3 Proteins (GLRX3)

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Glutaredoxin 3 Proteins (GLRX3)
On are 19 Glutaredoxin 3 (GLRX3) Proteins from 8 different suppliers available. Additionally we are shipping Glutaredoxin 3 Antibodies (87) and Glutaredoxin 3 Kits (18) and many more products for this protein. A total of 131 Glutaredoxin 3 products are currently listed.
GLRX4, GRX3, GRX4, PICOT, txnl2, TXNL3, wu:fb38e09, zgc:103648
list all proteins Gene Name GeneID UniProt
GLRX3 10539 O76003
GLRX3 30926 Q9CQM9
GLRX3 58815 Q9JLZ1

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Glutaredoxin 3 Proteins (GLRX3) by Origin

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Top referenced Glutaredoxin 3 Proteins

  1. Human GLRX3 Protein expressed in Escherichia coli (E. coli) - ABIN666992 : Haunhorst, Berndt, Eitner, Godoy, Lillig: Characterization of the human monothiol glutaredoxin 3 (PICOT) as iron-sulfur protein. in Biochemical and biophysical research communications 2010 (PubMed)
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More Proteins for Glutaredoxin 3 Interaction Partners

Human Glutaredoxin 3 (GLRX3) interaction partners

  1. The Glrx3.BolA is a [2Fe-2S] chaperone complex capable of transferring [2Fe-2S] clusters to apoproteins in human cells.

  2. apo (show C9orf3 Proteins) GRX3 and apo (show C9orf3 Proteins) BOLA2 form a heterotrimeric complex, composed by two BOLA2 molecules and one GRX3 molecule

  3. findings provide novel insights into the regulation of Grx3, which is crucial for cell survival against environmental insults

  4. These findings provide an advanced view of the functional role of glutaredoxin-3 in iron metabolism.

  5. These in vitro studies suggest that human GLRX3 is important for cytosolic Fe-S protein (show CDSN Proteins) maturation.

  6. Data indicate that silencing of Grx3 in HeLa cells decreases the activities of several cytosolic Fe/S proteins, including iron-regulatory protein 1, a major component of posttranscriptional iron regulation.

  7. these data raise the possibility that the pro-apoptotic role of PICOT is actively regulated via caspase-3 (show CASP3 Proteins)-mediated cleavage.

  8. the unusual [2Fe-2S]-bridging Grx-BolA interaction is conserved in higher eukaryotes and may play a role in signaling cellular iron status in humans.

  9. investigations into role of Grx3: Grx3-knockdown in HeLa cells leads to significant delay in mitotic exit and a higher percentage of binucleated cells.

  10. analysis of primary breast cancer samples demonstrated that enhanced TXNL2 expression correlated with metastasis to the lung and brain and with decreased overall patient survival

Mouse (Murine) Glutaredoxin 3 (GLRX3) interaction partners

  1. Grx3 is a key regulator of ROS (show ROS1 Proteins) in vivo and is involved in pregnancy-dependent mammary gland development and secretory activation through modulating cellular ROS (show ROS1 Proteins).

  2. Data show that protein kinase C-interacting cousin of thioredoxin (show TXN Proteins) (PICOT) alleviates myocardial I/R injury by regulating intracellular reactive oxygen species (ROS (show ROS1 Proteins)) and free iron levels, and suggest that PICOT presents a therapeutic strategy for myocardial I/R injury.

  3. investigation of role of Grx3: embryos absent Grx3 were small, morphological defects, early embryonic lethality; mRNA ubiquitously expressed in developing embryos, adult tissues; induced during oxidative stress; necessary for cell cycle progression

  4. These data suggest that AM and PICOT might play cooperatively essential roles in embryogenesis as iron-sulfur cluster proteins.

  5. Demonstrated a differential expression of PICOT in various cell types, with a predominant cytosolic staining of epithelial cells and low or undetectable levels of PICOT in the stroma.

  6. PICOT inhibits cardiac hypertrophy induced by pressure overload; overexpression increased ventricular function and cardiomyocyte contractility measured by ejection fraction & end-systolic pressure of transgenic hearts & peak shortening of cardiomyocytes

  7. PICOT regulated FcepsilonRI (show FCER1A Proteins)-mediated signals in RBL-2H3 cells and acted as a positive regulator on IL-4 (show IL4 Proteins) and TNF-alpha (show TNF Proteins) expression, NFAT (show NFATC1 Proteins) and degranulation and a negative regulator on a JNK (show MAPK8 Proteins) signal pathway.

  8. the precise PICOT protein level significantly affects the process of cardiac hypertrophy and cardiomyocyte contractility.

Zebrafish Glutaredoxin 3 (GLRX3) interaction partners

  1. Data indicate that during embryonic development, depletion of Grx3 severely impairs the maturation of hemoglobin, the major iron-consuming process.

Glutaredoxin 3 (GLRX3) Protein Profile

Protein Summary

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with Glutaredoxin 3 (GLRX3)

  • thioredoxin domain containing 6 (TXNDC6)
  • thioredoxin-like 2 (LOC100285323)
  • glutaredoxin 3 (GLRX3)
  • glutaredoxin 3 (Glrx3)
  • glutaredoxin 3 (LOC100344020)
  • glutaredoxin 3 (glrx3)
  • GLRX4 protein
  • GRX3 protein
  • GRX4 protein
  • PICOT protein
  • txnl2 protein
  • TXNL3 protein
  • wu:fb38e09 protein
  • zgc:103648 protein

Protein level used designations for Glutaredoxin 3 Proteins (GLRX3)

thioredoxin domain containing 6 , thioredoxin-like 2 , PKC-interacting cousin of thioredoxin , PKC-theta-interacting protein , PKCq-interacting protein , glutaredoxin 4 , glutaredoxin-3 , thioredoxin-like protein 2 , PKC interacting cousin of thioredoxin

745445 Pan troglodytes
100285323 Zea mays
10539 Homo sapiens
511528 Bos taurus
30926 Mus musculus
58815 Rattus norvegicus
100511783 Sus scrofa
423968 Gallus gallus
100344020 Oryctolagus cuniculus
100732347 Cavia porcellus
449777 Danio rerio
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