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Here, the first crystal structure of human liver FBPase in the R-state conformation is presented, determined at a resolution of 2.2 A in a tetragonal setting that exhibits an unusual arrangement of noncrystallographic symmetry (NCS) elements.
Studied association of fructose 1,6-bisphosphatase 1 (FBP1) expression with fluorine 18 ((18)F) fluorodeoxyglucose (FDG (show SMUG1 ELISA Kits)) accumulation in patients with hepatocellular carcinoma. Found that in patients with HCC (show FAM126A ELISA Kits), both 18F FDG (show SMUG1 ELISA Kits) accumulation and tumor grade (from differentiated to undifferentiated) were inversely correlated with the expression of FBP1.
These findings indicate that FBP1 appears to be a tumor suppressor in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)). Strategies to restore the levels and activities of FBP1 might be developed to treat patients with HCC (show FAM126A ELISA Kits).
FBP1 underexpression is associated with Tumor Progression in Hepatocellular Carcinoma.
fructose-1,6-bisphosphatase 1 facilitated co-action between Bcl-2 (show BCL2 ELISA Kits) and Beclin 1 (show BECN1 ELISA Kits), which may be important in the mechanism of fructose-1,6-bisphosphatase 1-mediated mitophagy inhibition. In summary, loss of mitophagy by fructose-1,6-bisphosphatase 1-mediated repression promotes apoptosis in breast cancer
Downregulation of FBP1 promotes gastric cancer metastasis by facilitating EMT (show ITK ELISA Kits) and acts as a potential prognostic factor and therapeutic target in gastric cancer.
we show that EV71 viral proteinase 2A is capable of cleaving far upstream element-binding protein 1 (show FUBP1 ELISA Kits) (FBP1), a positive internal ribosome entry sitet rans-acting factor that directly binds to the EV71 5' UTR (show UTS2R ELISA Kits) linker region to promote viral IRES-driven translation
Cox (show COX8A ELISA Kits) multivariate regression analysis demonstrated that DUOX1 (show DUOX1 ELISA Kits), GLS2 (show GLS2 ELISA Kits), FBP1 and age were independent risk factors for the prognosis of HCC (show FAM126A ELISA Kits) patients after surgery
Elevated FBP1 is a critical modulator in breast cancer progression by altering glucose metabolism and the activity of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathway.
identified Zinc finger E-box-binding homeobox 1 (ZEB1 (show ZEB1 ELISA Kits)) bond to FBP1 promoter to enhance DNA methylation (show HELLS ELISA Kits) in lung cancer cells. Our findings indicate that the down-regulation of FBP1 is a critical oncogenic event in lung cancer progression
The Identification of FBPase interacting partners with mass spectrometry reveals a set of nuclear proteins involved in cell cycle regulation, mRNA processing and in stabilization of genomic DNA structure.
FBPase plays an important role in regulating glucose sensing and insulin (show INS ELISA Kits) secretion of beta-cells and serves a promising target for diabetes treatment.
Data show that NF-kappaB (show NFKB1 ELISA Kits) functions downstream of Ras to promote epigenetic downregulation of FBP1 (show FBP2 ELISA Kits).
Directed mutations, kinetics, and structure determinations link the central cavity of FBP to AMP (show TMPRSS5 ELISA Kits)/fructose 2,6-bisphosphate synergism.
The AMP (show TMPRSS5 ELISA Kits)/Mg(2 (show MCOLN1 ELISA Kits)+) and AMP (show TMPRSS5 ELISA Kits)/Zn(2+) complexes of Asp (show ASIP ELISA Kits)(10) FBPase are in intermediate quaternary conformations.
each subunit in the wild-type tetramer can independently achieve maximum velocity when activated by Mg(2 (show MCOLN1 ELISA Kits)+); findings are fully consistent with a mechanism of cooperativity that arises from within a single subunit of fructose-1,6-bisphosphatase.
Ca2 (show CA2 ELISA Kits)+ appears to be a strong inhibitor of muscle FBPase (fructose 1,6-diphosphatase).
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
, FBPase 1
, fructose-bisphosphatase 1
, growth-inhibiting protein 17
, D-fructose-1,6-bisphosphate 1-phosphohydrolase 3
, FBPase brain isoform
, FBPase liver
, fructose-1,6-bisphosphatase 1
, fructose-1,6-bisphosphatase isozyme 3
, fructose 1,6-bisphosphatase
, Fructose-16- biphosphatase
, fructose-1,6- biphosphatase 1
, fructose-1,6-bisphosphatase 1, like
, fructose-bisphosphatase 1 S homeolog