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This is the first evaluation of humans without GN2 expression. Our data indicate that GN2 is not required for liver glycogen (show GYS1 Proteins) synthesis and glucagon (show GCG Proteins)-stimulated glucose release.
The glucosylation of glycogenin-2 was enhanced to 2-4 glucose units by the co-presence of enzymatically active glycogenin-1 (show GYG1 Proteins).
This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver\; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
, glycogenin glucosyltransferase