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Browse our Histone Deacetylase 8 Proteins (HDAC8)

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Histone Deacetylase 8 Proteins (HDAC8)
On are 24 Histone Deacetylase 8 (HDAC8) Proteins from 10 different suppliers available. Additionally we are shipping Histone Deacetylase 8 Antibodies (162) and Histone Deacetylase 8 Kits (15) and many more products for this protein. A total of 216 Histone Deacetylase 8 products are currently listed.
2610007D20Rik, ATHDA8, CDLS5, HD8, HDA8, HDACL1, histone deacetylase 8, MRXS6, RGD1562895, RPD3, T27G7.14, T27G7_14, WTS, wu:fd19a02, zgc:66196
list all proteins Gene Name GeneID UniProt
HDAC8 55869 Q9BY41
HDAC8 70315 Q8VH37
HDAC8 363481 B1WC68

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Histone Deacetylase 8 Proteins (HDAC8) by Origin

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Top referenced Histone Deacetylase 8 Proteins

  1. Mouse (Murine) HDAC8 Protein expressed in Baculovirus infected Insect Cells - ABIN2007594 : Hu, Chen, Fredrickson, Zhu, Kirkpatrick, Zhang, Johanson, Sung, Liu, Winkler: Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor. in The Journal of biological chemistry 2000 (PubMed)
    Show all 3 references for ABIN2007594

  2. Human HDAC8 Protein expressed in Baculovirus infected Insect Cells - ABIN2003497 : Buggy, Sideris, Mak, Lorimer, McIntosh, Clark: Cloning and characterization of a novel human histone deacetylase, HDAC8. in The Biochemical journal 2001 (PubMed)
    Show all 3 references for ABIN2003497

More Proteins for Histone Deacetylase 8 Interaction Partners

Human Histone Deacetylase 8 (HDAC8) interaction partners

  1. Losses of catalytic efficiency in histone deacetylase 8 (HDAC8) are observed for G304A and G305A mutations.

  2. Data suggest sequencing of histone deacetylase 8 protein (HDAC8) as an indispensable part of the routine molecular diagnostic for patients with Cornelia de Lange syndrome (CdLS (show NIPBL Proteins)) or CdLS (show NIPBL Proteins)-overlapping features.

  3. HDAC8 were overexpressed in oral squamous cell carcinoma tissues, mainly localized in the cytoplasm.

  4. Study reveals that HDAC8 can bind and catalyze deacetylation of many acetylated peptides with sequences corresponding to cellular, non-histone proteins, thereby opening a new window to the functional role of HDAC8 in cells.

  5. Findings suggest the therapeutic potential of histone deacetylase 8 histone (HDAC8)inhibition to suppress Notch1 (show NOTCH1 Proteins) signaling in breast cancer.

  6. Data show that histone deacetylase 8 (HDAC8) inhibition led to accumulation of acetylated-SMC3 (show SMC3 Proteins) protein but had no influence on the transcription of estrogen-responsive genes.

  7. study elucidates an HDAC8-mediated p53 (show TP53 Proteins)-inactivating mechanism promoting leukemia stem cells activity

  8. Studies indicate that histone deacetylase 8 protein (HDAC8) aberrantly deacetylates p53 (show TP53 Proteins) protein and promotes leukemia stem cells (LSCs) transformation and maintenance.

  9. Our data exhibited an important role of HDAC8 in promoting gastric cancer tumorigenesis and identify this HDAC8 as a potential therapeutic target for the treatment of gastric cancer.

  10. The H143A and H142A/H143A mutants exhibit activity that is >80000-fold lower than that of wild-type HDAC8; the buried D176N and D176A mutants have significant catalytic effects, with more subtle effects caused by D183N and D183A

Mouse (Murine) Histone Deacetylase 8 (HDAC8) interaction partners

  1. this study demonstrates a novel role of HDAC8 in LeTx immunotoxicity and regulation of pro-IL-1beta (show IL1B Proteins) production likely through eRNAs.

  2. findings show how HDAC8 drives nonalcoholic fatty liver disease-associated hepatocarcinogenesis

  3. Data reveal a role for miR-21-3p in regulating HDAC8 expression and Akt/Gsk3beta pathway in cardiac hypertrophy.

  4. histone deacetylase 8 inhibition reduces gene expression and production of proinflammatory cytokines in vitro and in vivo

  5. HDAC8 and Sirt1 (show SIRT1 Proteins) were also demonstrated to interact directly with ERRalpha (show ESRRA Proteins) in vivo and to deacetylate and increase the DNA binding affinity of ERRalpha (show ESRRA Proteins) in vitro.

  6. Global deletion of Hdac8 in mice leads to perinatal lethality due to skull instability, and deletion of Hdac8 in cranial neural crest cells and Hdac8 specifically represses the aberrant expression of homeobox (show PRRX1 Proteins) transcription factors such as Otx2 (show OTX2 Proteins) and Lhx1 (show LHX1 Proteins)

Histone Deacetylase 8 (HDAC8) Protein Profile

Protein Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Histone Deacetylase 8 (HDAC8)

  • histone deacetylase 8 (CC1G_05302)
  • histone deacetylase 8 (hdac8)
  • histone deacetylase 8 (HDAC8)
  • histone deacetylase 8 (Hdac8)
  • histone deacetylase 8 (HDA08)
  • 2610007D20Rik protein
  • ATHDA8 protein
  • CDLS5 protein
  • HD8 protein
  • HDA8 protein
  • HDACL1 protein
  • histone deacetylase 8 protein
  • MRXS6 protein
  • RGD1562895 protein
  • RPD3 protein
  • T27G7.14 protein
  • T27G7_14 protein
  • WTS protein
  • wu:fd19a02 protein
  • zgc:66196 protein

Protein level used designations for Histone Deacetylase 8 Proteins (HDAC8)

histone deacetylase 8 , histone deacetylase-like 1 , HD8

6017058 Coprinopsis cinerea okayama7130
100145561 Xenopus (Silurana) tropicalis
55869 Homo sapiens
70315 Mus musculus
363481 Rattus norvegicus
406740 Danio rerio
444137 Xenopus laevis
540666 Bos taurus
480957 Canis lupus familiaris
422182 Gallus gallus
100721893 Cavia porcellus
837366 Arabidopsis thaliana
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