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Browse our PCDH12 Proteins (PCDH12)

Full name:
Protocadherin 12 Proteins (PCDH12)
On www.antibodies-online.com are 7 Protocadherin 12 (PCDH12) Proteins from 2 different suppliers available. Additionally we are shipping PCDH12 Antibodies (23) and many more products for this protein. A total of 36 PCDH12 products are currently listed.
Synonyms:
PCDH12, Pcdh14, VE-cad-2, VE-cadherin-2, VECAD2
list all proteins Gene Name GeneID UniProt
PCDH12 51294 Q9NPG4
PCDH12 53601 O55134
Rat PCDH12 PCDH12 116808  

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PCDH12 Proteins (PCDH12) by Origin

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Human Protocadherin 12 (PCDH12) interaction partners

  1. Genome-wide analysis to determine the genetic cause of a microcephaly syndrome; found that loss of function of PCDH12 leads to recessive congenital microcephaly with profound developmental disability

  2. PCDH12 may play an important role in human placental development, and proteolytic cleavage in response to external factors, such as cytokines and pathological settings, regulates its activity

  3. A putative association was also found between protocadherin 12 and cortical folding (asymmetry coefficient of gyrification index).

Mouse (Murine) Protocadherin 12 (PCDH12) interaction partners

  1. The reactivity to acetylcholine and the circumferential mid-wall stress decreased with ageing in the PCDH12(-/-) mice, as opposed to the increase observed in the wild types.

  2. PCDH12 has a unique expression pattern and its deficiency does not lead to conspicuous abnormalities; it is the first specific marker for both glycogen (show GYS1 Proteins)-rich trophoblasts and mesangial cells.

  3. Loss of PCDH12 leads to morphological alterations of the placenta and to notable changes in its gene expression profile.

PCDH12 Protein Profile

Protein Summary

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth.

Alternative names and synonyms associated with PCDH12

  • protocadherin 12 (PCDH12)
  • protocadherin 12 (Pcdh12)
  • PCDH12 protein
  • Pcdh14 protein
  • VE-cad-2 protein
  • VE-cadherin-2 protein
  • VECAD2 protein

Protein level used designations for Protocadherin 12 Proteins (PCDH12)

protocadherin 12 , VE-cad-2 , VE-cadherin 2 , protocadherin-12 , vascular cadherin-2 , vascular endothelial cadherin 2 , vascular endothelial cadherin-2 , VE-cadherin-2 , protocadherin 14

GENE ID SPECIES
100072150 Equus caballus
705232 Macaca mulatta
51294 Homo sapiens
487191 Canis lupus familiaris
540115 Bos taurus
53601 Mus musculus
116808 Rattus norvegicus
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