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Browse our Chemokine (C-C Motif) Ligand 2 Proteins (CCL2)

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Chemokine (C-C Motif) Ligand 2 Proteins (CCL2)
On are 140 Chemokine (C-C Motif) Ligand 2 (CCL2) Proteins from 19 different suppliers available. Additionally we are shipping Chemokine (C-C Motif) Ligand 2 Antibodies (550) and Chemokine (C-C Motif) Ligand 2 Kits (179) and many more products for this protein. A total of 890 Chemokine (C-C Motif) Ligand 2 products are currently listed.
AI323594, GDCF-2, HC11, HSMCR30, JE, MCAF, MCP-1, MCP-1A, MCP1, MCP1A, SCYA2, Sigje, SMC-CF
list all proteins Gene Name GeneID UniProt
CCL2 24770 P14844
CCL2 6347 P13500
CCL2 20296 P10148

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Chemokine (C-C Motif) Ligand 2 Proteins (CCL2) by Origin

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Top referenced Chemokine (C-C Motif) Ligand 2 Proteins

  1. Mouse (Murine) CCL2 Protein expressed in HEK-293 - ABIN2666606 : Qiu, Dillen, Hu, Verbeke, Struyf, Van Damme, Opdenakker: Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes. in Immunobiology 2009 (PubMed)
    Show all 6 references for ABIN2666606

  2. Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN2666695 : McQuibban, Gong, Wong, Wallace, Clark-Lewis, Overall: Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. in Blood 2002 (PubMed)
    Show all 5 references for ABIN2666695

  3. Rat (Rattus) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305099 : Capsoni, Minonzio, Ongari, Zanussi: A new simplified single-filter assay for 'in vitro' evaluation of chemotaxis of 51Cr-labeled polymorphonuclear leukocytes. in Journal of immunological methods 1989 (PubMed)
    Show all 5 references for ABIN1305099

  4. Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305100 : Ernst, Zhang, Hancock, Rutledge, Corless, Rollins: Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains. in Journal of immunology (Baltimore, Md. : 1950) 1994 (PubMed)
    Show all 5 references for ABIN1305100

  5. Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1046668 : Rollins, Morrison, Stiles: Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. in Proceedings of the National Academy of Sciences of the United States of America 1988 (PubMed)
    Show all 3 references for ABIN1046668

  6. Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305101 : Rollins, Stier, Ernst, Wong: The human homolog of the JE gene encodes a monocyte secretory protein. in Molecular and cellular biology 1990 (PubMed)
    Show all 2 references for ABIN1305101

  7. Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN666739 : Rafei, Campeau, Aguilar-Mahecha, Buchanan, Williams, Birman, Yuan, Young, Boivin, Forner, Basik, Galipeau: Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Show all 2 references for ABIN666739

  8. Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413594 : Gray, Di Marco, Okabe, Szyndralewiez, Heitz, Montezano, de Haan, Koulis, El-Osta, Andrews, Chin-Dusting, Touyz, Wingler, Cooper, Schmidt, Jandeleit-Dahm: NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. in Circulation 2013 (PubMed)

More Proteins for Chemokine (C-C Motif) Ligand 2 Interaction Partners

Human Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. the -2518A/G polymorphism in the MCP-1 gene was found to be associated with an increased susceptibility to Pulmonary tuberculosis (PTB (show PTBP1 Proteins)) in a North Chinese population.

  2. in Argentine patients, MCP-1 gene polymorphism confers susceptibility for developing rheumatoid arthritis

  3. we revealed a novel mechanism of pyruvate kinase M2 in promoting colorectal cancer progression by recruitment of macrophages through p65 (show GORASP1 Proteins) nuclear factor-kappaB-mediated expression of CCL2.

  4. this study shows that that the CCL2 levels are increased in renal transplant rejection group when compared with the non-rejection, stable-graft, and control

  5. MCP-1 and NT-proBNP are independent predictors of SS, while low calcidiol plasma levels are associated with CAC (show CA2 Proteins)

  6. the expression of CCL2 is significantly correlated with Snail (show SNAI1 Proteins) expression and may be used as a predictive co-biomarker for patient prognosis and tumor aggressiveness in gastric cancer.

  7. plasma MCP-1 is a useful biomarker in predicting outcome of sepsis.

  8. Data show that (show FAS Proteins) serum chemokine CCL2 levels were significantly higher in systemic (show CXCL12 Proteins) lupus erythematosus (SLE) patients as compared to controls, and serum levels of chemokine CXCL12 were identical in both groups.

  9. Women with the GG CCL2 rs1024611 and CC rs4586 genotype tended to have lower body mass and BMI increases during pregnancy, as well as lower newborn body mass. The study suggest an association between CCL2 gene polymorphisms and Gestational Diabetes.

  10. MCP-1 and RANTES (show CCL5 Proteins) levels (ng/mg total protein) of gingivitis group were higher than those of the MSH groups (P=0.005, P=0.0001, respectively).

Mouse (Murine) Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. Data show that loss of loss of matrix metalloproteinase-3 (MMP-3 (show MMP3 Proteins)) repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 (show CPT1B Proteins) and (C-X-C motif) ligand 1 (CXCL1 (show CXCL1 Proteins)).

  2. These data indicated that alpha7-nAChR (show CHRNA7 Proteins) caused the inhibition of ASPinduced activation of p38 (show CRK Proteins) kinase and NFkappa B to inhibit the production of MCP1 and keratinocytederived chemokine (show CCL1 Proteins).

  3. Female MRL/lpr (show FAS Proteins) mice treated with dual blockade of the chemokines CCL2 and CXCL12 (show CXCL12 Proteins) showed significantly more effective than either monotherapy in preventing proteinuria and immune complex glomerulonephritis.

  4. Data show that RP105 (show GPR83 Proteins) knockout (-/-) smooth muscle cells and mast cells secreted higher levels of chemokine (C-C motif) ligand 2 protein (CCL2).

  5. CCL2/CCL3 (show CCL3 Proteins) double-mutant animals are viable, fertile, and do not present with gross abnormalities. Cuprizone increased CCL2 expression in wild-type but not mutant miCuprizone-induced demyelination, oligodendrocyte loss, and astrogliosis were significantly ameliorated in the cortex but not corpus callosum of chemokine (show CCL1 Proteins)-deficient animals.

  6. study suggests that MCP-1 (show CPT1B Proteins) might promote intracerebral hemorrhage-induced microglia activation and toxicity to neurons

  7. Results show that CCL2 from astrocytes selectively induces microglial activation associated with M1 polarization and enhanced migration ability.

  8. kiss1 (show KISS1 Proteins) and kiss1r mRNA levels were significantly higher in old compared to reproductive-aged mice, and diet-induced obesity did not alter kiss1 (show KISS1 Proteins) or kiss1r mRNA levels. Compared to young control mice, young MCP-1 (show CPT1B Proteins) knockout mice had significantly lower ovarian kiss1 (show KISS1 Proteins) mRNA

  9. In 3T3-L1 preadipocytes, Ad36, but not E4orf1, increased MCP1 and TNFalpha (show TNF Proteins) mRNA, in presence of LPS (show TLR4 Proteins) stimulation.

  10. Probiotic Lactobacillus reuteri can prevent the exacerbating effects of stressor exposure on Citrobacter-induced colitis; one mechanism by which this occurs is through downregulation of the chemokine (show CCL1 Proteins) CCL2.

Cow (Bovine) Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. resence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1beta and monocyte chemoattractant protein-1, compared with patients without diabetes

  2. Studied SNPs in the bovine toll-like receptor 4 (TLR4 (show TLR4 Proteins)) and monocyte chemo attractant protein-1(CCL2) genes.

  3. The LEP (show LEP Proteins), IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.

  4. immune cells and endothelial cells can interact cooperatively to increase CCL2 secretion in the corpus luteum

Rabbit Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. Data show that peripheral blood endothelial progenitor cells can increase the expressions of chemokines CCL2 and CXCL12 (show CXCL12 Proteins) and promote the migration of enhanced green fluorescent protein-positive bone marrow stromal cells to bone defect site.

  2. In a cerebral aneurysm, expression of MCP1 peaked after induction for one week, then decreased. MCP1 induced macrophage adhesion and infiltration in the artery wall of aneurysms, and contributed to the occurrence and development of brain aneurysm.

  3. Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8 (show IL8 Proteins)) decreased significantly in Dachengqi decoction treatment group.

  4. measurements of CCL2 and macrophages can serve as new inflammatory biomarkers to evaluate the safety of promising novel microbicides for prevention of HIV.

  5. Expression of MCP-1 was successfully inhibited by transfecting MCP-1 siRNA expression plasmid to the carotid artery, and the progression of atherosclerosis was restricted by RNAi-mediated silencing of MCP-1 expression.

Pig (Porcine) Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. CXCL10 (show CXCL10 Proteins) protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.

  2. Porcine CCL2 binding on Tuk4+SLA (show SLA Proteins)-II- but not on Tuk4-SLA (show SLA Proteins)-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein.

  3. The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.

  4. MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment

  5. Contrast media did not affect bone marrow cell viability/MCP-1 secretion.

  6. Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern.

  7. in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta

  8. Variable gene expression (eg, matrix metalloproteinase-9 (show MMP9 Proteins), CCL2 and Lp-PLA(2 (show Lp-PLA2 Proteins)) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.

  9. myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor (show F3 Proteins) cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP (show CRP Proteins)

Chemokine (C-C Motif) Ligand 2 (CCL2) Protein Profile

Protein Summary

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Alternative names and synonyms associated with Chemokine (C-C Motif) Ligand 2 (CCL2)

  • chemokine (C-C motif) ligand 2 (CCL2)
  • chemokine (C-C motif) ligand 2 (Ccl2)
  • macrophage cationic peptide 1 (MCP-1)
  • mast cell proteinase-1 (MCP1)
  • AI323594 protein
  • GDCF-2 protein
  • HC11 protein
  • HSMCR30 protein
  • JE protein
  • MCAF protein
  • MCP-1 protein
  • MCP-1A protein
  • MCP1 protein
  • MCP1A protein
  • SCYA2 protein
  • Sigje protein
  • SMC-CF protein

Protein level used designations for CCL2

small inducible cytokine A2 , C-C motif chemokine 2 , immediate-early serum-responsive JE protein , immediate-early serum-responsive protein JE , monocyte chemoattractant protein 1 , monocyte chemoattractant protein-1 , monocyte chemotactic protein 1 , small inducible gene JE , small-inducible cytokine A2 , monocyte chemotactic and activating factor , monocyte secretory protein JE , small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je) , small inducible cytokine subfamily A (Cys-Cys), member 2 , platelet-derived growth factor-inducible protein JE , acidic seminal fluid protein , monocyte chemotactic protein 1A , MCP-1 , chemokine CCL2/MCP-1 , CS-III , NP-1 , antiadrenocorticotropin peptide III , corticostatin III , corticostatin-3 , macrophage antibiotic peptide MCP-1 , SMCP-1A , mast cell protease 1A

748205 Pan troglodytes
24770 Rattus norvegicus
6347 Homo sapiens
20296 Mus musculus
281043 Bos taurus
100009130 Oryctolagus cuniculus
397422 Sus scrofa
403981 Canis lupus familiaris
100135494 Cavia porcellus
100034136 Equus caballus
100172740 Pongo abelii
101120093 Ovis aries
574138 Macaca mulatta
100009115 Oryctolagus cuniculus
443546 Ovis aries
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