Browse our Chemokine (C-C Motif) Ligand 2 Proteins (CCL2)

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Chemokine (C-C Motif) Ligand 2 Proteins (CCL2)
On www.antibodies-online.com are 128 Chemokine (C-C Motif) Ligand 2 (CCL2) Proteins from 20 different suppliers available. Additionally we are shipping Chemokine (C-C Motif) Ligand 2 Antibodies (536) and Chemokine (C-C Motif) Ligand 2 Kits (186) and many more products for this protein. A total of 872 Chemokine (C-C Motif) Ligand 2 products are currently listed.
Synonyms:
AI323594, GDCF-2, HC11, HSMCR30, JE, MCAF, MCP-1, MCP-1A, MCP1, MCP1A, SCYA2, Sigje, SMC-CF
list all proteins Gene Name GeneID UniProt
CCL2 24770 P14844
CCL2 6347 P13500
CCL2 20296 P10148

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Chemokine (C-C Motif) Ligand 2 Proteins (CCL2) by Origin

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Top referenced Chemokine (C-C Motif) Ligand 2 Proteins

  1. Mouse (Murine) CCL2 Protein expressed in HEK-293 - ABIN2666606 : Qiu, Dillen, Hu, Verbeke, Struyf, Van Damme, Opdenakker: Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes. in Immunobiology 2009 (PubMed)
    Show all 6 references for 2666606

  2. Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN2666695 : McQuibban, Gong, Wong, Wallace, Clark-Lewis, Overall: Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. in Blood 2002 (PubMed)
    Show all 5 references for 2666695

  3. Rat (Rattus) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305099 : Capsoni, Minonzio, Ongari, Zanussi: A new simplified single-filter assay for 'in vitro' evaluation of chemotaxis of 51Cr-labeled polymorphonuclear leukocytes. in Journal of immunological methods 1989 (PubMed)
    Show all 5 references for 1305099

  4. Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305100 : Ernst, Zhang, Hancock, Rutledge, Corless, Rollins: Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains. in Journal of immunology (Baltimore, Md. : 1950) 1994 (PubMed)
    Show all 5 references for 1305100

  5. Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1046668 : Rollins, Morrison, Stiles: Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. in Proceedings of the National Academy of Sciences of the United States of America 1988 (PubMed)
    Show all 3 references for 1046668

  6. Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305101 : Rollins, Stier, Ernst, Wong: The human homolog of the JE gene encodes a monocyte secretory protein. in Molecular and cellular biology 1990 (PubMed)
    Show all 2 references for 1305101

  7. Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN666739 : Rafei, Campeau, Aguilar-Mahecha, Buchanan, Williams, Birman, Yuan, Young, Boivin, Forner, Basik, Galipeau: Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Show all 2 references for 666739

  8. Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413594 : Gray, Di Marco, Okabe, Szyndralewiez, Heitz, Montezano, de Haan, Koulis, El-Osta, Andrews, Chin-Dusting, Touyz, Wingler, Cooper, Schmidt, Jandeleit-Dahm: NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. in Circulation 2013 (PubMed)

More Proteins for Chemokine (C-C Motif) Ligand 2 Interaction Partners

Human Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. conclude that MCP-1/CCL2 plays a significant role in the pathogenesis of sepsis, which has potentially important therapeutic implications

  2. Data suggest that MCP1/CCL2 induces activation/tyrosine phosphorylation of ARHGEF1/p115-RhoGEF (show ARHGEF1 Proteins) and up-regulates RAC1 signaling in vascular smooth muscle cells (VSMCs); ARHGEF1 (show ARHGEF1 Proteins) inhibition suppresses MCP1-induced VSMC migration and proliferation. (ARHGEF1 (show ARHGEF1 Proteins) = Rho guanine nucleotide exchange factor 1 (show ARHGEF1 Proteins); RAC1 = Rac (show AKT1 Proteins) family small GTPase (show RACGAP1 Proteins) 1; CCL2 = C-C motif chemokine ligand 2 (show CXCL2 Proteins))

  3. A polarized secretion assay suggested that the silencing of endothelial myeloid-secretory impairs T effector transendothelial migration by reducing the preferential secretion of endothelial-produced CCL2

  4. In cultured macrophages, LPS (show IRF6 Proteins)-induced expression of monocyte chemoattractant protein (MCP)-1 was suppressed by NaN3 through inhibition of STAT1 (show STAT1 Proteins) and IkappaBzeta (show NFKBIZ Proteins) activities.

  5. CCL2/CCR2 (show CCR2 Proteins) axis is expressed in the majority of monocytoid Acute myeloid leukemia (show BCL11A Proteins) blasts

  6. identified CCL2 as a novel KIT D816V-dependent key regulator of vascular cell migration and angiogenesis in systemic mastocytosis

  7. This study establishes ECL1i as the first allosteric inhibitor of CCR2 with functional selectivity.

  8. Constitutive expression of CCL2 by the mouse mammary epithelium induces a state of low level chronic inflammation that increases stromal density and elevates cancer risk. We propose that CCL2-driven inflammation contributes to the increased risk of breast cancer observed in women with high mammographic density.

  9. CCR4-deficient Treg and CCR2-deficient monocyticmyeloid-derived suppressor cells (MDSC) were defective in glioma accumulation.

  10. Urine, but not plasma, MCP-1 levels are associated with hospital readmission, development of complications of cirrhosis, and mortality.

Mouse (Murine) Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. type I interferons, besides their known antiviral properties, can initiate the recruitment and activation of leukocytes via induction of chemokine (show CCL1 Proteins) expression including CCL2.

  2. In cultured macrophages, LPS (show TLR4 Proteins)-induced expression of monocyte chemoattractant protein (MCP)-1 (show CPT1B Proteins) was suppressed by NaN3 through inhibition of STAT1 (show STAT1 Proteins) and IkappaBzeta (show NFKBIZ Proteins) activities.

  3. study concludes that CCL2 signaling onto melanin-concentrating hormone (show PMCH Proteins) neurons represents a core mechanism that relays peripheral inflammation to sickness behavior

  4. The increased migratory phenotypes are dependent on secreted factors, including the cytokine interleukin-6 (show IL6 Proteins) and the chemokine (show CCL1 Proteins) CCL2. We propose that Delta122p53 (and Delta133p53) acts in a similar manner to 'gain-of-function' mutant p53 (show TP53 Proteins) proteins to promote migration, invasion and metastasis, which may contribute to poor survival in patients with Delta133p53-expressing tumours

  5. CCL5 (show CCL5 Proteins) paradoxically limits macrophage accumulation in the injured kidney during renin (show REN Proteins) angiotensin system (RAS) activation by constraining the proinflammatory actions of CCL2.

  6. This study establishes ECL1i as the first allosteric inhibitor of CCR2 with functional selectivity.

  7. Constitutive expression of CCL2 by the mouse mammary epithelium induces a state of low level chronic inflammation that increases stromal density and elevates cancer risk. We propose that CCL2-driven inflammation contributes to the increased risk of breast cancer observed in women with high mammographic density.

  8. the individual and combined actions of CCL2/CCR2 (show CCR2 Proteins) and CX3CL1 (show CX3CL1 Proteins)/CX3CR1 (show CX3CR1 Proteins) in hypoxia-induced pulmonary hypertension in mice, is reported.

  9. CCL2 acting at the suprachiasmatic nuclei level is important for the circadian effects of immune activation.

  10. FAP (show FAP Proteins)-STAT3 (show STAT3 Proteins)-CCL2 signaling in Cancer-associated fibroblasts (CAF (show LAMA2 Proteins)) was sufficient to program an inflammatory component of the tumor microenvironment, which may have particular significance in desmoplasia-associated cancers.

Cow (Bovine) Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. resence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1beta and monocyte chemoattractant protein-1, compared with patients without diabetes

  2. Studied SNPs in the bovine toll-like receptor 4 (TLR4 (show TLR4 Proteins)) and monocyte chemo attractant protein-1(CCL2) genes.

  3. The LEP (show LEP Proteins), IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.

  4. immune cells and endothelial cells can interact cooperatively to increase CCL2 secretion in the corpus luteum

Rabbit Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. Data show that peripheral blood endothelial progenitor cells can increase the expressions of chemokines CCL2 and CXCL12 (show CXCL12 Proteins) and promote the migration of enhanced green fluorescent protein-positive bone marrow stromal cells to bone defect site.

  2. In a cerebral aneurysm, expression of MCP1 peaked after induction for one week, then decreased. MCP1 induced macrophage adhesion and infiltration in the artery wall of aneurysms, and contributed to the occurrence and development of brain aneurysm.

  3. Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8 (show IL8 Proteins)) decreased significantly in Dachengqi decoction treatment group.

  4. measurements of CCL2 and macrophages can serve as new inflammatory biomarkers to evaluate the safety of promising novel microbicides for prevention of HIV.

  5. Expression of MCP-1 was successfully inhibited by transfecting MCP-1 siRNA expression plasmid to the carotid artery, and the progression of atherosclerosis was restricted by RNAi-mediated silencing of MCP-1 expression.

Pig (Porcine) Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. CXCL10 (show CXCL10 Proteins) protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.

  2. Porcine CCL2 binding on Tuk4+SLA (show SLA Proteins)-II- but not on Tuk4-SLA (show SLA Proteins)-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein.

  3. The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.

  4. MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment

  5. Contrast media did not affect bone marrow cell viability/MCP-1 secretion.

  6. Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern.

  7. in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta

  8. Variable gene expression (eg, matrix metalloproteinase-9 (show MMP9 Proteins), CCL2 and Lp-PLA(2 (show Lp-PLA2 Proteins)) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.

  9. myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor (show F3 Proteins) cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP (show CRP Proteins)

Chemokine (C-C Motif) Ligand 2 (CCL2) Protein Profile

Protein Summary

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Alternative names and synonyms associated with Chemokine (C-C Motif) Ligand 2 (CCL2)

  • chemokine (C-C motif) ligand 2 (CCL2)
  • chemokine (C-C motif) ligand 2 (Ccl2)
  • macrophage cationic peptide 1 (MCP-1)
  • mast cell proteinase-1 (MCP1)
  • AI323594 protein
  • GDCF-2 protein
  • HC11 protein
  • HSMCR30 protein
  • JE protein
  • MCAF protein
  • MCP-1 protein
  • MCP-1A protein
  • MCP1 protein
  • MCP1A protein
  • SCYA2 protein
  • Sigje protein
  • SMC-CF protein

Protein level used designations for CCL2

small inducible cytokine A2 , C-C motif chemokine 2 , immediate-early serum-responsive JE protein , immediate-early serum-responsive protein JE , monocyte chemoattractant protein 1 , monocyte chemoattractant protein-1 , monocyte chemotactic protein 1 , small inducible gene JE , small-inducible cytokine A2 , monocyte chemotactic and activating factor , monocyte secretory protein JE , small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je) , small inducible cytokine subfamily A (Cys-Cys), member 2 , platelet-derived growth factor-inducible protein JE , acidic seminal fluid protein , monocyte chemotactic protein 1A , MCP-1 , chemokine CCL2/MCP-1 , CS-III , NP-1 , antiadrenocorticotropin peptide III , corticostatin III , corticostatin-3 , macrophage antibiotic peptide MCP-1 , SMCP-1A , mast cell protease 1A

GENE ID SPECIES
748205 Pan troglodytes
24770 Rattus norvegicus
6347 Homo sapiens
20296 Mus musculus
281043 Bos taurus
100009130 Oryctolagus cuniculus
397422 Sus scrofa
403981 Canis lupus familiaris
100135494 Cavia porcellus
100034136 Equus caballus
100172740 Pongo abelii
101120093 Ovis aries
574138 Macaca mulatta
100009115 Oryctolagus cuniculus
443546 Ovis aries
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