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Rat (Rattus) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305099
Capsoni, Minonzio, Ongari, Zanussi: A new simplified single-filter assay for 'in vitro' evaluation of chemotaxis of 51Cr-labeled polymorphonuclear leukocytes. in Journal of immunological methods 1989
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305100
Ernst, Zhang, Hancock, Rutledge, Corless, Rollins: Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains. in Journal of immunology (Baltimore, Md. : 1950) 1994
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Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN935624
Frøyland, Pedersen, Kvissel, Almaas, Pharo, Skålhegg, Mollnes, Rootwelt: Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons. in Brain research 2006
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN935595
Bogen, Dina, Gear, Levine: Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican. in Neuroscience 2009
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Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305101
Rollins, Stier, Ernst, Wong: The human homolog of the JE gene encodes a monocyte secretory protein. in Molecular and cellular biology 1990
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413564
Zhu, Daghini, Chade, Rodriguez-Porcel, Napoli, Lerman, Lerman: Role of oxidative stress in remodeling of the myocardial microcirculation in hypertension. in Arteriosclerosis, thrombosis, and vascular biology 2006
Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413594
Gray, Di Marco, Okabe, Szyndralewiez, Heitz, Montezano, de Haan, Koulis, El-Osta, Andrews, Chin-Dusting, Touyz, Wingler, Cooper, Schmidt, Jandeleit-Dahm: NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. in Circulation 2013
Testosterone increases CCL-2 expression in visceral adipose tissue from obese women of reproductive age.
ATF4 (show ATF4 Proteins) contributes to tumor growth of endometrial cancer (EC) by promoting CCL2 and subsequent recruitment of macrophage, and ATF4 (show ATF4 Proteins)/CCL2 axis might be a potential therapeutic target for EC.
we could provide evidence that established stress-related biomarkers ET-1 (show EDN1 Proteins), MCP-1, CGA (show CGA Proteins) were differentially regulated among patients with AF compared to healthy controls.
a molecular mechanism of oxidized low density lipoprotein antibody on inhibition of oxLDL-induced ERK MAPK (show MAPK1 Proteins) pathway and consequent MCP-1 release.
tumor-promoting role for CCL2 acting through CCR2 on the tumor microenvironment
conclude that MCP-1/CCL2 plays a significant role in the pathogenesis of sepsis, which has potentially important therapeutic implications
Data suggest that MCP1/CCL2 induces activation/tyrosine phosphorylation of ARHGEF1/p115-RhoGEF (show ARHGEF1 Proteins) and up-regulates RAC1 signaling in vascular smooth muscle cells (VSMCs); ARHGEF1 (show ARHGEF1 Proteins) inhibition suppresses MCP1-induced VSMC migration and proliferation. (ARHGEF1 (show ARHGEF1 Proteins) = Rho guanine nucleotide exchange factor 1 (show ARHGEF1 Proteins); RAC1 = Rac (show AKT1 Proteins) family small GTPase (show RACGAP1 Proteins) 1; CCL2 = C-C motif chemokine ligand 2 (show CXCL2 Proteins))
A polarized secretion assay suggested that the silencing of endothelial myeloid-secretory impairs T effector transendothelial migration by reducing the preferential secretion of endothelial-produced CCL2
In cultured macrophages, LPS (show IRF6 Proteins)-induced expression of monocyte chemoattractant protein (MCP)-1 was suppressed by NaN3 through inhibition of STAT1 (show STAT1 Proteins) and IkappaBzeta (show NFKBIZ Proteins) activities.
CCL2/CCR2 (show CCR2 Proteins) axis is expressed in the majority of monocytoid Acute myeloid leukemia (show BCL11A Proteins) blasts
CCL2 recruits T cells into the brain in a CCR2-independent manner.
Expression of MCP-1 (show CPT1B Proteins) induced by IL-17 (show IL17A Proteins) requires NF-kappaB (show NFKB1 Proteins) through the phosphorylation of p65 (show NFkBP65 Proteins) in cardiac myocytes.
this study demonstrates that killed probiotics can reduce viral disease severity and identify that the MCP-1 (show CPT1B Proteins) pathway might act as a key mediator in the improved antiviral immune response
type I interferons, besides their known antiviral properties, can initiate the recruitment and activation of leukocytes via induction of chemokine (show CCL1 Proteins) expression including CCL2.
In cultured macrophages, LPS (show TLR4 Proteins)-induced expression of monocyte chemoattractant protein (MCP)-1 (show CPT1B Proteins) was suppressed by NaN3 through inhibition of STAT1 (show STAT1 Proteins) and IkappaBzeta (show NFKBIZ Proteins) activities.
study concludes that CCL2 signaling onto melanin-concentrating hormone (show PMCH Proteins) neurons represents a core mechanism that relays peripheral inflammation to sickness behavior
The increased migratory phenotypes are dependent on secreted factors, including the cytokine interleukin-6 (show IL6 Proteins) and the chemokine (show CCL1 Proteins) CCL2. We propose that Delta122p53 (and Delta133p53) acts in a similar manner to 'gain-of-function' mutant p53 (show TP53 Proteins) proteins to promote migration, invasion and metastasis, which may contribute to poor survival in patients with Delta133p53-expressing tumours
CCL5 (show CCL5 Proteins) paradoxically limits macrophage accumulation in the injured kidney during renin (show REN Proteins) angiotensin system (RAS) activation by constraining the proinflammatory actions of CCL2.
This study establishes ECL1i as the first allosteric inhibitor of CCR2 with functional selectivity.
resence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1beta and monocyte chemoattractant protein-1, compared with patients without diabetes
Studied SNPs in the bovine toll-like receptor 4 (TLR4 (show TLR4 Proteins)) and monocyte chemo attractant protein-1(CCL2) genes.
The LEP (show LEP Proteins), IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
immune cells and endothelial cells can interact cooperatively to increase CCL2 secretion in the corpus luteum
Data show that peripheral blood endothelial progenitor cells can increase the expressions of chemokines CCL2 and CXCL12 (show CXCL12 Proteins) and promote the migration of enhanced green fluorescent protein-positive bone marrow stromal cells to bone defect site.
In a cerebral aneurysm, expression of MCP1 peaked after induction for one week, then decreased. MCP1 induced macrophage adhesion and infiltration in the artery wall of aneurysms, and contributed to the occurrence and development of brain aneurysm.
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8 (show IL8 Proteins)) decreased significantly in Dachengqi decoction treatment group.
measurements of CCL2 and macrophages can serve as new inflammatory biomarkers to evaluate the safety of promising novel microbicides for prevention of HIV.
Expression of MCP-1 was successfully inhibited by transfecting MCP-1 siRNA expression plasmid to the carotid artery, and the progression of atherosclerosis was restricted by RNAi-mediated silencing of MCP-1 expression.
CXCL10 (show CXCL10 Proteins) protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.
Porcine CCL2 binding on Tuk4+SLA (show SLA Proteins)-II- but not on Tuk4-SLA (show SLA Proteins)-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein.
The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.
MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment
Contrast media did not affect bone marrow cell viability/MCP-1 secretion.
Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern.
in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta
Variable gene expression (eg, matrix metalloproteinase-9 (show MMP9 Proteins), CCL2 and Lp-PLA(2 (show Lp-PLA2 Proteins)) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor (show F3 Proteins) cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP (show CRP Proteins)
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
small inducible cytokine A2
, C-C motif chemokine 2
, immediate-early serum-responsive JE protein
, immediate-early serum-responsive protein JE
, monocyte chemoattractant protein 1
, monocyte chemoattractant protein-1
, monocyte chemotactic protein 1
, small inducible gene JE
, small-inducible cytokine A2
, monocyte chemotactic and activating factor
, monocyte secretory protein JE
, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
, small inducible cytokine subfamily A (Cys-Cys), member 2
, platelet-derived growth factor-inducible protein JE
, acidic seminal fluid protein
, monocyte chemotactic protein 1A
, chemokine CCL2/MCP-1
, antiadrenocorticotropin peptide III
, corticostatin III
, macrophage antibiotic peptide MCP-1
, mast cell protease 1A