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CX3CL1 (show CX3CL1 Proteins) is upregulated in both human and murine tumors following VEGF (show VEGFA Proteins) signaling blockade, resulting in recruitment of CX3CR1+Ly6Clo monocytes into the tumor
The fractalkine (show CX3CL1 Proteins) functions on the activation of the AKT (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins)/p65 (show GORASP1 Proteins) signalling cascade and regulation of the antiapoptosis process in pancreatic cancer cells.
High expression of CX3CR1 correlates with significantly shorter survival, specifically in post-menopausal patients with advanced and terminal stages of the disease. Taken together, this support a key regulatory role for the fractalkine (show CX3CL1 Proteins) axis in advanced and relapsed peritoneal metastasis in epithelial ovarian carcinoma.
V249I genotype of the fractalkine receptor showed a protector role in patients with type 2 diabetes. The T280M genotype is associated with increased carotid intima-media thickness in Mexican individuals with or without type 2 diabetes
CX3CR1 genetic variation sows a possible association with hypertension, diabetes mellitus and atherosclerosis comorbidities in patients treated with hemodialysis.
this study shows that the expression of CX3CR1 on tonsillar CD8-positive cells is higher in IgA nephropathy patients
Low CCRL1 expression is associated with hepatocellular carcinoma.
Recent works show that, in allergic diseases, there is an increased expression of fractalkine/CX3CL1 (show CX3CL1 Proteins) and its unique receptor CX3CR1 and that this chemokine (show CCL1 Proteins) does not act as chemoattractant. In allergic asthma, CX3CR1 expression regulates Th2 and Th1 (show TH1L Proteins) cell survival in the inflammatory lung, while, in atopic dermatitis, it regulate Th2 and Th1 (show TH1L Proteins) cell retention into the inflammatory site. [review]
CX3CR1 is expressed in the normal, cancer adjacent normal, inflammatory, and malignant fallopian epithelium.
CX3CR1 T allele of rs3732379 might have a positive association with the susceptibility of age-related macular degeneration
Results indicate that deletion of CX3CR1 from microglia under resting conditions modifies brain areas with elevated cellular turnover independent of CX3CL1 (show CX3CL1 Proteins).
The CX3CL1 (show CX3CL1 Proteins)/CX3CR1 system is essential for restricting coxsackievirus B3-induced myocarditis.
Results establish an essential role for the receptor CX3CR1 in gut (show GUSB Proteins) macrophages in resolving inflammation in the intestine, where it helps protects against colitis-associated cancer by regulating HMOX-1 (show HMOX1 Proteins) expression.
CX3CR1 significantly contributes to changes in microglia morphology in the proximal peri (show POSTN Proteins)-infarct area following transient occlusion of the middle cerebral artery. Morphological alterations suggest a shift in microglia functionality integrated in the inflammatory response after stroke. Results show that CX3CR1 deficiency has no beneficial effect on lesion size neither it affects early functional outcome after stroke.
we demonstrated that CX3CR1(Lo)CCR2 (show CCR2 Proteins)(Hi) monocytes were recruited to the GBM, where they transitioned to CX3CR1(Hi)CCR2 (show CCR2 Proteins)(Lo) macrophages and CX3CR1(Hi)CCR2 (show CCR2 Proteins)(-) microglia-like cells. Infiltrating macrophages/monocytes constituted approximately 85% of the total TAM (show CCNA1 Proteins) population, with resident microglia accounting for the approximately 15% remaining.
CXCR4 (show CXCR4 Proteins), CCR2 (show CCR2 Proteins), and CX3CR1 direct dendritic cell precursors from the bone marrow to the lung differentially.
Published data show that genetic deletion of CX3CR1, a microglia-specific chemokine receptor, promotes recovery after traumatic spinal cord injury in mice, a benefit achieved in part by reducing macrophage-mediated injury at the lesion epicenter. Data in the current manuscript indicate that CX3CR1 deletion changes microglia and macrophage function, creating a tissue microenvironment that enhances endogenous repair.
this reduction in lesion formation was associated with reduced numbers of lesional SMCs but not macrophages within the transplanted Cx3cr-/- Apoe (show APOE Proteins)-/- aortic segment. No differences in frequencies of proliferating and apoptotic cells could be observed. These results indicate that CX3CR1 on resident vessel wall cells plays a key role in atherosclerotic plaque formation in transplanted aortic grafts
the individual and combined actions of CCL2 (show CCL2 Proteins)/CCR2 (show CCR2 Proteins) and CX3CL1 (show CX3CL1 Proteins)/CX3CR1 in hypoxia-induced pulmonary hypertension in mice, is reported.
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene.
CX3C chemokine receptor 1
, chemokine (C-C motif) receptor-like 1
, CX3C chemokine receptor 1-like
, c-C chemokine receptor type 11-like
, chemokine (C-X3-C motif) receptor 1
, C-X-C chemokine receptor type 1
, chemokine receptor CXCR1
, C-X3-C CKR-1
, chemokine (C-X3-C) receptor 1
, fractalkine receptor
, G protein-coupled receptor 13
, G-protein coupled receptor 13
, beta chemokine receptor-like 1
, chemokine (C-C) receptor-like 1
, Fractalkine receptor
, chemokine receptor 1